SYNE2 and NR2C1

		SYNE2	NR2C1
Description		spectrin repeat containing nuclear envelope protein 2	nuclear receptor subfamily 2 group C member 1
Image			No pdb structure
GO Annotations	Cellular Component	Fibrillar Center Nucleus Nuclear Envelope Nuclear Outer Membrane Nucleoplasm Nucleolus Cytoplasm Mitochondrion Cytoskeleton Plasma Membrane Focal Adhesion Cilium Membrane Sarcoplasmic Reticulum Myofibril Z Disc Lamellipodium Membrane Filopodium Membrane Nuclear Membrane Nuclear Lumen Sarcoplasmic Reticulum Membrane Meiotic Nuclear Membrane Microtubule Tethering Complex Intermediate Filament Cytoskeleton Extracellular Exosome Anchoring Junction	Chromatin Nucleus Nucleoplasm PML Body
	Molecular Function	Actin Binding Protein Binding Cytoskeleton-nuclear Membrane Anchor Activity	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding DNA-binding Transcription Factor Activity Nuclear Steroid Receptor Activity Nuclear Receptor Activity Protein Binding Zinc Ion Binding Signaling Receptor Activity Protein Homodimerization Activity Histone Deacetylase Binding Sequence-specific DNA Binding Metal Ion Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Nuclear Migration Nucleokinesis Involved In Cell Motility In Cerebral Cortex Radial Glia Guided Migration Positive Regulation Of Cell Migration Nuclear Migration Along Microfilament Centrosome Localization Regulation Of Cilium Assembly	Negative Regulation Of Transcription By RNA Polymerase II Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Differentiation Nuclear Receptor-mediated Steroid Hormone Signaling Pathway Intracellular Receptor Signaling Pathway Negative Regulation Of DNA-templated Transcription Positive Regulation Of Retinoic Acid Receptor Signaling Pathway
Pathways		Meiotic synapsis	Nuclear Receptor transcription pathway SUMOylation of intracellular receptors
Drugs
Diseases		Emery-Dreifuss muscular dystrophy
GWAS		Anorexia nervosa, attention-deficit/hyperactivity disorder, autism spectrum disorder, bipolar disorder, major depression, obsessive-compulsive disorder, schizophrenia, or Tourette syndrome (pleiotropy) ( 31835028) Atrial fibrillation ( 22544366 28416818 29892015 30061737) Blond vs. brown/black hair color ( 30531825) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) Depression ( 29700475) HDL cholesterol levels ( 32109663) Metabolite levels ( 23823483) Nevus count or cutaneous melanoma ( 30429480 32341527) PR interval ( 32439900) Psoriasis ( 25854761) Pulmonary function decline ( 22424883) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 33031748) Serum metabolite ratios in chronic kidney disease ( 29545352) Sphingomyelin levels ( 31551469) Youthful appearance (self-reported) ( 32339537)	Body fat mass ( 28552196) Chromosomal aberration frequency (chromosome type) ( 31586183) Coronary artery disease ( 32469254) Intracranial aneurysm ( 33199917) Trunk fat mass ( 28552196)
Interacting Genes		12 interacting genes: ABI1 ACTC1 BRAP CALM1 CTNNB1 MAPK3 MAPK8IP2 MEOX2 MTNR1B PML RNF10 SASH1	8 interacting genes: AR ESR1 HDAC3 HDAC4 NR2C2 NRIP1 NUDT3 RARA
Entrez ID		23224	7181
HPRD ID		09763	03318
Ensembl ID		ENSG00000054654	ENSG00000120798
Uniprot IDs		Q8WXH0	H9NIM2 H9NIM3 P13056
PDB IDs		4DXS 4FI9 6XF1
Enriched GO Terms of Interacting Partners?		Trachea Formation Positive Regulation Of Cell Communication Intracellular Signaling Cassette Intracellular Signal Transduction MAPK Cascade Positive Regulation Of Telomere Maintenance Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Nuclear Receptor-mediated Signaling Pathway Animal Organ Formation Regulation Of Nervous System Process Nuclear Steroid Receptor Activity Positive Regulation Of Signal Transduction Protein Modification By Small Protein Conjugation Positive Regulation Of Intracellular Signal Transduction Hormone-mediated Signaling Pathway Regulation Of Signal Transduction Positive Regulation Of Macromolecule Metabolic Process Positive Regulation Of Signaling Regulation Of Stress-activated MAPK Cascade Anatomical Structure Formation Involved In Morphogenesis Lamellipodium Protein Kinase Binding Post-translational Protein Modification Positive Regulation Of MAPK Cascade Regulation Of Stress-activated Protein Kinase Signaling Cascade Positive Regulation Of Metabolic Process Anatomical Structure Morphogenesis Regulation Of Cell Communication Regulation Of Calcium Ion Transport Regulation Of Signaling Regulation Of Telomere Maintenance Via Telomerase Thymus Development Glial Cell Fate Determination SMAD Binding Negative Regulation Of Gliogenesis Phosphatase Binding Regulation Of Myelination Canonical Wnt Signaling Pathway Involved In Mesenchymal Stem Cell Differentiation Regulation Of Telomere Maintenance Via Telomere Lengthening Limb Development Nuclear Receptor Activity Intracellular Receptor Signaling Pathway Negative Regulation Of Translation In Response To Oxidative Stress Dendrite Morphogenesis Sarcomere Glutamatergic Synapse Regulation Of System Process	Nuclear Receptor Activity Cellular Response To Estrogen Stimulus Negative Regulation Of Transcription By RNA Polymerase II Chromatin Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of Transcription By RNA Polymerase II Histone Deacetylase Binding Negative Regulation Of RNA Metabolic Process Histone Deacetylase Complex Negative Regulation Of Nucleobase-containing Compound Metabolic Process Transcription Coactivator Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Intracellular Receptor Signaling Pathway Response To Estrogen Positive Regulation Of RNA Metabolic Process Regulation Of MiRNA Transcription Positive Regulation Of Nucleobase-containing Compound Metabolic Process Transcription By RNA Polymerase II Regulation Of MiRNA Metabolic Process Prostate Gland Growth Histone Deacetylase Activity, Hydrolytic Mechanism Estrogen Response Element Binding Negative Regulation Of Macromolecule Biosynthetic Process Nuclear Receptor-mediated Signaling Pathway Negative Regulation Of Biosynthetic Process Cellular Response To Hormone Stimulus Protein Deacetylation Protein Lysine Deacetylase Activity Male Gonad Development Response To Lipid Response To Estradiol Enzyme Binding Mammary Gland Alveolus Development Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Myotube Differentiation DNA-templated Transcription Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Macromolecule Biosynthetic Process Gonad Development Histone Deacetylase Activity Hormone-mediated Signaling Pathway Positive Regulation Of Biosynthetic Process Sequence-specific DNA Binding Nucleoplasm Nuclear Steroid Receptor Activity Cellular Response To Lipid Prostate Gland Epithelium Morphogenesis
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