DNAH8 and RAB44

		DNAH8	RAB44
Description		dynein axonemal heavy chain 8	RAB44, member RAS oncogene family
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Cytoskeleton Axonemal Dynein Complex Microtubule Cilium Axoneme Dynein Complex Motile Cilium Sperm Flagellum Outer Dynein Arm Cell Projection 9+2 Motile Cilium	Lysosomal Membrane Plasma Membrane Membrane Azurophil Granule Membrane Specific Granule Membrane Specific Granule
	Molecular Function	Nucleotide Binding Microtubule Motor Activity ATP Binding Minus-end-directed Microtubule Motor Activity Dynein Intermediate Chain Binding Dynein Light Intermediate Chain Binding	Nucleotide Binding GTPase Activity G Protein Activity Calcium Ion Binding Protein Binding GTP Binding
	Biological Process	Microtubule-based Movement Outer Dynein Arm Assembly Cilium-dependent Cell Motility Cilium Movement Involved In Cell Motility	Histamine Secretion By Mast Cell Vesicle-mediated Transport Mast Cell Degranulation Histamine Secretion Mediated By IgE Immunoglobulin
Pathways			Neutrophil degranulation RAB geranylgeranylation
Drugs
Diseases
GWAS		3-month functional outcome in ischaemic stroke (modified Rankin score) ( 30796134) Bell's palsy ( 33602968) Circulating leptin levels in high cardiovascular risk ( 31766143) Femur bone mineral density x serum urate levels interaction ( 34046847) Smoking status (heavy vs never) ( 26423011)	Cortical thickness ( 32310165) Lateral occipital cortex volume ( 31530798)
Interacting Genes
Entrez ID		1769	401258
HPRD ID		04515	13470
Ensembl ID		ENSG00000124721	ENSG00000255587
Uniprot IDs		A0A075B6F3 Q8IU65 Q96JB1	Q7Z6P3
PDB IDs
Enriched GO Terms of Interacting Partners?		Leukocyte Degranulation Mast Cell Degranulation Inflammatory Response To Antigenic Stimulus Lysosome Localization Regulated Exocytosis Histamine Secretion Mediated By IgE Immunoglobulin Exocytosis Establishment Of Organelle Localization Establishment Of Localization In Cell Histamine Secretion By Mast Cell Secretion By Cell Immune Effector Process Positive Regulation Of T Cell Differentiation In Thymus Histamine Transport Histamine Secretion Mitochondrial Outer Membrane Translocase Complex TOM Complex Positive Regulation Of Natural Killer Cell Differentiation Organelle Localization Diacylglycerol Binding Regulation Of Natural Killer Cell Differentiation Response To Histamine Specific Granule Protein Insertion Into Mitochondrial Outer Membrane Secretion Inflammatory Response Positive Regulation Of Ras Protein Signal Transduction Secretory Granule Localization Calcium Ion Binding Activation Of GTPase Activity Regulation Of T Cell Differentiation In Thymus Positive Regulation Of Natural Killer Cell Activation GTPase Regulator Activity Positive Regulation Of Natural Killer Cell Mediated Cytotoxicity Phosphatidylcholine Binding Protein Insertion Into Mitochondrial Membrane Establishment Of Protein Localization To Mitochondrial Membrane Positive Regulation Of MAP Kinase Activity Positive Regulation Of Natural Killer Cell Mediated Immunity B Cell Proliferation Regulation Of Natural Killer Cell Activation Vesicle Transport Along Microtubule Regulation Of Ras Protein Signal Transduction Regulation Of Natural Killer Cell Mediated Cytotoxicity Azurophil Granule Membrane Vesicle Cytoskeletal Trafficking Natural Killer Cell Activation Regulation Of Natural Killer Cell Mediated Immunity Positive Regulation Of Protein Serine/threonine Kinase Activity Regulation Of MAP Kinase Activity	9+2 Motile Cilium Dynein Intermediate Chain Binding Outer Dynein Arm Assembly Axonemal Dynein Complex Assembly Minus-end-directed Microtubule Motor Activity Outer Dynein Arm Dynein Light Intermediate Chain Binding Axonemal Dynein Complex Dynein Complex Microtubule Motor Activity Sperm Flagellum Axoneme Cilium Movement Involved In Cell Motility Cilium-dependent Cell Motility Cilium Movement Motile Cilium Microtubule Microtubule-based Movement
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