AKT3 and SDCCAG8

		AKT3	SDCCAG8
Description		AKT serine/threonine kinase 3	SHH signaling and ciliogenesis regulator SDCCAG8
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Golgi Apparatus Cytosol Plasma Membrane Cilium Membrane Ciliary Basal Body	Nucleoplasm Cytoplasm Centrosome Centriole Cytosol Cytoskeleton Cell-cell Junction Cilium Centriolar Satellite Ciliary Basal Body Cell Projection Anchoring Junction Photoreceptor Cell Cilium
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Serine/threonine Kinase Activity Protein Binding ATP Binding Kinase Activity Transferase Activity Protein Serine Kinase Activity	Protein Binding
	Biological Process	Positive Regulation Of Endothelial Cell Proliferation Protein Phosphorylation Signal Transduction Insulin Receptor Signaling Pathway Positive Regulation Of Cell Migration Positive Regulation Of TOR Signaling Intracellular Signal Transduction Negative Regulation Of Apoptotic Process Positive Regulation Of Blood Vessel Endothelial Cell Migration Positive Regulation Of Angiogenesis Positive Regulation Of Cell Size Brain Morphogenesis Homeostasis Of Number Of Cells Within A Tissue Positive Regulation Of Cell Migration Involved In Sprouting Angiogenesis Negative Regulation Of PERK-mediated Unfolded Protein Response Positive Regulation Of Vascular Endothelial Cell Proliferation Positive Regulation Of Artery Morphogenesis Negative Regulation Of Cellular Senescence	Neuron Migration Centrosome Cycle Establishment Of Cell Polarity Cell Projection Organization Microtubule Organizing Center Organization Tube Formation Regulation Of Cilium Assembly
Pathways		Activation of BAD and translocation to mitochondria PIP3 activates AKT signaling PIP3 activates AKT signaling Downregulation of ERBB2:ERBB3 signaling AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the cytosol AKT phosphorylates targets in the nucleus Negative regulation of the PI3K/AKT network AKT-mediated inactivation of FOXO1A CD28 dependent PI3K/Akt signaling Co-inhibition by CTLA4 G beta:gamma signalling through PI3Kgamma VEGFR2 mediated vascular permeability TP53 Regulates Metabolic Genes Constitutive Signaling by AKT1 E17K in Cancer Regulation of TP53 Degradation Regulation of TP53 Activity through Acetylation Regulation of TP53 Activity through Association with Co-factors Cyclin E associated events during G1/S transition Cyclin A:Cdk2-associated events at S phase entry RAB GEFs exchange GTP for GDP on RABs RUNX2 regulates genes involved in cell migration Regulation of PTEN stability and activity FLT3 Signaling Regulation of localization of FOXO transcription factors Estrogen-dependent nuclear events downstream of ESR-membrane signaling KEAP1-NFE2L2 pathway SARS-CoV-2 targets host intracellular signalling and regulatory pathways Transcriptional and post-translational regulation of MITF-M expression and activity	Regulation of PLK1 Activity at G2/M Transition Loss of Nlp from mitotic centrosomes Recruitment of mitotic centrosome proteins and complexes Loss of proteins required for interphase microtubule organization from the centrosome Recruitment of NuMA to mitotic centrosomes Anchoring of the basal body to the plasma membrane AURKA Activation by TPX2
Drugs
Diseases
GWAS		Adult body size ( 32376654) Adult diffuse glioma (IDH mutation) ( 32386320) Adventurousness ( 30643258) Antisaccade task score ( 31596458) Apolipoprotein A1 levels ( 32203549) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diabetic retinopathy ( 21441570) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) ghrelin levels ( 33852427) Height ( 28552196) Menarche (age at onset) ( 23599027) Monocyte count ( 32888494) Non-glioblastoma glioma ( 28346443) Platelet distribution width ( 32888494) Post-traumatic stress disorder (asjusted for relatedness) ( 23726511) RR interval (heart rate) ( 20031603) Schizophrenia ( 25056061 23974872 28991256 30285260 29483656) Self-reported risk-taking behaviour ( 30181555) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545)	Adult body size ( 32376654) Appendicular lean mass ( 33097823) Brain morphology (min-P) ( 32665545) Brain morphology (MOSTest) ( 32665545) Chronic kidney disease ( 31152163 29124443) Cognitive ability (MTAG) ( 29186694) Cognitive ability, years of educational attainment or schizophrenia (pleiotropy) ( 31374203) Cortical surface area (min-P) ( 32665545) Cortical surface area (MOSTest) ( 32665545) Cortical thickness (MOSTest) ( 32665545) Diastolic blood pressure ( 28135244 30578418 27841878) Diastolic blood pressure x alcohol consumption interaction (2df test) ( 29912962) Diastolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Diastolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858) Educational attainment ( 25201988) Estimated glomerular filtration rate ( 31451708 30604766 31015462 31152163) General risk tolerance (MTAG) ( 30643258) Glomerular filtration rate (creatinine) ( 26831199) Mean platelet volume ( 32888494) Mental health study participation (completed survey) ( 31263887) Metabolite levels ( 23823483) Multisite chronic pain ( 33830993) Obesity (early onset extreme) ( 20421936) Platelet distribution width ( 32888494) Pulse pressure ( 30578418) Schizophrenia ( 30285260 29483656 25056061 23974872) Schizophrenia, schizoaffective disorder or bipolar disorder ( 24166486) Self-reported risk-taking behaviour ( 30271922) Subcortical volume (min-P) ( 32665545) Subcortical volume (MOSTest) ( 32665545) Toenail selenium levels ( 25343990) Walking pace ( 33128006)
Interacting Genes		12 interacting genes: CRYAA FBXO7 GSK3B IWS1 NEDD4 NEDD4L PDPK1 PPP2CA PRKCD PRKCZ TCL1A TSC2	2 interacting genes: FBXO7 TNS2
Entrez ID		10000	10806
HPRD ID		06441	10215
Ensembl ID		ENSG00000117020	ENSG00000054282
Uniprot IDs		A0A5F9ZHU3 A0A7P0TB32 A0A7P0TBJ6 Q9Y243	Q86SQ7
PDB IDs		2X18 8ZXW
Enriched GO Terms of Interacting Partners?		Regulation Of Transport Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Positive Regulation Of Catabolic Process Regulation Of Intracellular Signal Transduction Intracellular Signal Transduction Regulation Of Cellular Component Organization Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization Negative Regulation Of Signaling Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Protein Kinase Binding Regulation Of Intracellular Transport Protein Modification Process Regulation Of Nucleocytoplasmic Transport Regulation Of Cellular Localization Negative Regulation Of Epithelial To Mesenchymal Transition Negative Regulation Of Potassium Ion Export Across Plasma Membrane Negative Regulation Of Cellular Response To Insulin Stimulus Negative Regulation Of Insulin Receptor Signaling Pathway Cytoplasm Regulation Of Protein Stability Sodium Channel Inhibitor Activity Positive Regulation Of Nucleocytoplasmic Transport Regulation Of Dendrite Morphogenesis Developmental Process Negative Regulation Of Transport Negative Regulation Of Cation Transmembrane Transport Regulation Of Membrane Potential Regulation Of Neuron Projection Development Potassium Channel Inhibitor Activity Negative Regulation Of Monoatomic Ion Transmembrane Transport Negative Regulation Of Intracellular Signal Transduction Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Insulin Receptor Signaling Pathway Regulation Of Cellular Response To Insulin Stimulus Nucleus Regulation Of Potassium Ion Export Across Plasma Membrane Cytosol Protein Metabolic Process Insulin Receptor Substrate Binding Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Negative Regulation Of Sodium Ion Transport Positive Regulation Of Cell Communication Regulation Of Signal Transduction Positive Regulation Of Signaling Negative Regulation Of Apoptotic Process Establishment Of Cell Polarity Regulation Of Monoatomic Cation Transmembrane Transport Vascular Endothelial Cell Response To Fluid Shear Stress	Negative Regulation Of Signal Transduction Negative Regulation Of Cell Communication Negative Regulation Of Signaling Glial Cytoplasmic Inclusion Classical Lewy Body Lewy Body Corona Lewy Neurite Lewy Body Core Dendrite Terminus
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