ANAPC7 and CDT1

Number of citations of the paper that reports this interaction (PubMedID 18162579)
69

Data Source:
BioGRID (pull down)

		ANAPC7	CDT1
Description		anaphase promoting complex subunit 7	chromatin licensing and DNA replication factor 1
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GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle	Chromosome, Centromeric Region Kinetochore Nucleus Nucleoplasm Chromosome Nuclear Body
	Molecular Function	Protein Phosphatase Binding Enzyme-substrate Adaptor Activity	DNA Binding Chromatin Binding Protein Binding DNA Polymerase Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Brain Development Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	DNA Replication Checkpoint Signaling Mitotic Cell Cycle DNA Replication Regulation Of DNA-templated DNA Replication Initiation Regulation Of Nuclear Cell Cycle DNA Replication Positive Regulation Of Chromatin Binding Positive Regulation Of DNA Replication Negative Regulation Of Cell Cycle Cell Division Attachment Of Mitotic Spindle Microtubules To Kinetochore DNA Replication Preinitiation Complex Assembly Response To Sorbitol Negative Regulation Of DNA-templated DNA Replication Positive Regulation Of DNA-templated DNA Replication
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state G1/S-Specific Transcription
Drugs
Diseases			Patella dysplasias, including: Small patella syndrome (SPS); Nail-patella syndrome; Ear-patella-short statute syndrome
GWAS		Bipolar disorder ( 31043756) QT interval ( 30679814) Schizophrenia ( 28991256) Total intracranial volume ( 31530798)	Glycated hemoglobin levels ( 28898252) Hair color ( 26926045) Hemoglobin A1c levels ( 29403010) Mean corpuscular hemoglobin concentration ( 20139978 28017375 29403010) Mean corpuscular volume ( 29403010)
Interacting Genes		19 interacting genes: ANAPC10 ANAPC2 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CEBPA CREBBP FBXO5 FZR1 HSPB1 OGT PTEN PTGER4 UBC UBE2S WASHC4	28 interacting genes: ANAPC7 BAZ1B CCNA2 CCNB1 CDC20 CDC23 CDC5L CDC6 CDK1 CDK2 COL6A3 DTL EP300 FBXO31 FOXO3 FZR1 GMNN KAT2B MAPK14 MCM4 MCM6 NPM1 ORC1 ORC2 PCNA SKP2 SMARCA5 UBB
Entrez ID		51434	81620
HPRD ID		16233	06900
Ensembl ID		ENSG00000196510	ENSG00000167513
Uniprot IDs		Q4KMX6 Q9UJX3	Q9H211
PDB IDs		3FFL 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	2LE8 2WVR 6QCG 8RWV 8S0E 8S0F
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Binding Regulation Of Meiotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Metaphase/anaphase Transition Of Cell Cycle Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Protein Branched Polyubiquitination Post-translational Protein Modification Regulation Of Chromosome Segregation Protein Ubiquitination Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Modification-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spindle Regulation Of Chromosome Organization Ubiquitin Ligase Activator Activity Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Process Nucleoplasm Regulation Of Nuclear Division Protein Polyubiquitination Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Component Organization Proteolysis Regulation Of Organelle Organization Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Senescence	Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Regulation Of Cell Cycle Regulation Of Cell Cycle Process Regulation Of Cell Cycle Phase Transition Nucleoplasm Regulation Of DNA Replication DNA Damage Response Cellular Response To Stress DNA Replication DNA Metabolic Process Negative Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Organization Regulation Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle G2/M Phase Transition Mitotic DNA Integrity Checkpoint Signaling Macromolecule Metabolic Process Nucleic Acid Metabolic Process Signal Transduction In Response To DNA Damage Regulation Of DNA Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition DNA Damage Checkpoint Signaling G2/M Transition Of Mitotic Cell Cycle Positive Regulation Of Cell Cycle Process Anaphase-promoting Complex-dependent Catabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Cell Cycle G2/M Phase Transition DNA Replication Initiation Negative Regulation Of Mitotic Cell Cycle Positive Regulation Of Mitotic Cell Cycle Regulation Of Chromosome Segregation Positive Regulation Of Cell Cycle Post-translational Protein Modification Mitotic Cell Cycle Phase Transition Nucleobase-containing Compound Metabolic Process DNA Repair Regulation Of Primary Metabolic Process Cell Cycle Phase Transition Regulation Of DNA-templated DNA Replication Initiation Regulation Of Organelle Organization Chromosome, Telomeric Region Response To Stress Mitotic G2/M Transition Checkpoint Cell Division Chromatin Binding Anaphase-promoting Complex
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