ANAPC7 and ANAPC2

Number of citations of the paper that reports this interaction (PubMedID 10922056)
42

Data Source:
HPRD (in vivo)

		ANAPC7	ANAPC2
Description		anaphase promoting complex subunit 7	anaphase promoting complex subunit 2
Image
GO Annotations	Cellular Component	Heterochromatin Nucleus Nucleoplasm Anaphase-promoting Complex Cytoplasm Spindle Cytosol Cytoskeleton Microtubule Cytoskeleton Intercellular Bridge Mitotic Spindle	Nucleoplasm Anaphase-promoting Complex Cytosol Cullin-RING Ubiquitin Ligase Complex
	Molecular Function	Protein Phosphatase Binding Enzyme-substrate Adaptor Activity	Protein Binding Ubiquitin Protein Ligase Binding
	Biological Process	Regulation Of Mitotic Cell Cycle Brain Development Protein Ubiquitination Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Mitotic Metaphase/anaphase Transition Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Protein Branched Polyubiquitination	Ubiquitin-dependent Protein Catabolic Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Regulation Of Mitotic Cell Cycle Nervous System Development Proteasomal Protein Catabolic Process Negative Regulation Of Gene Expression Protein Ubiquitination Cell Differentiation Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Synaptic Plasticity Positive Regulation Of Axon Extension Positive Regulation Of Dendrite Morphogenesis Cell Division Regulation Of Meiotic Cell Cycle Protein K48-linked Ubiquitination Protein K11-linked Ubiquitination Positive Regulation Of Synapse Maturation Protein Branched Polyubiquitination
Pathways		Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation	Inactivation of APC/C via direct inhibition of the APC/C complex APC/C:Cdc20 mediated degradation of Cyclin B Autodegradation of Cdh1 by Cdh1:APC/C APC/C:Cdc20 mediated degradation of Securin APC/C:Cdh1 mediated degradation of Cdc20 and other APC/C:Cdh1 targeted proteins in late mitosis/early G1 Cdc20:Phospho-APC/C mediated degradation of Cyclin A Conversion from APC/C:Cdc20 to APC/C:Cdh1 in late anaphase Regulation of APC/C activators between G1/S and early anaphase APC/C:Cdc20 mediated degradation of mitotic proteins Phosphorylation of the APC/C APC-Cdc20 mediated degradation of Nek2A Separation of Sister Chromatids Senescence-Associated Secretory Phenotype (SASP) Assembly of the pre-replicative complex CDK-mediated phosphorylation and removal of Cdc6 Transcriptional Regulation by VENTX Aberrant regulation of mitotic exit in cancer due to RB1 defects Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Bipolar disorder ( 31043756) QT interval ( 30679814) Schizophrenia ( 28991256) Total intracranial volume ( 31530798)	Eosinophil percentage of white cells ( 32888494)
Interacting Genes		19 interacting genes: ANAPC10 ANAPC2 BUB1B CDC16 CDC20 CDC27 CDH1 CDT1 CEBPA CREBBP FBXO5 FZR1 HSPB1 OGT PTEN PTGER4 UBC UBE2S WASHC4	17 interacting genes: ANAPC11 ANAPC7 CDC20 CDC26 CDC27 FZR1 MAD2L1 MEOX1 PTTG1 SMAD2 SUMO2 UBC UBE2C UBE2D2 UFD1 USP16 WDR5
Entrez ID		51434	29882
HPRD ID		16233	07367
Ensembl ID		ENSG00000196510	ENSG00000176248
Uniprot IDs		Q4KMX6 Q9UJX3	Q9UJX6
PDB IDs		3FFL 4UI9 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW	4UI9 4YII 5A31 5G04 5G05 5KHR 5KHU 5L9T 5L9U 5LCW 6NXK 6OB1 6Q6G 6Q6H 6TLJ 6TM5 6TNT 8PKP 8TAR 8TAU 9GAW
Enriched GO Terms of Interacting Partners?		Anaphase-promoting Complex Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Binding Regulation Of Meiotic Cell Cycle Protein K11-linked Ubiquitination Cell Division Metaphase/anaphase Transition Of Cell Cycle Regulation Of Reproductive Process Regulation Of Mitotic Cell Cycle Regulation Of Sister Chromatid Segregation Regulation Of Cell Cycle Protein Branched Polyubiquitination Post-translational Protein Modification Regulation Of Chromosome Segregation Protein Ubiquitination Protein Modification Process Regulation Of Ubiquitin-protein Transferase Activity Protein Modification By Small Protein Conjugation Positive Regulation Of Ubiquitin Protein Ligase Activity Regulation Of Cell Cycle Process Metaphase/anaphase Transition Of Mitotic Cell Cycle Negative Regulation Of Cell Cycle Modification-dependent Protein Catabolic Process Negative Regulation Of Cell Cycle Phase Transition Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Spindle Regulation Of Chromosome Organization Ubiquitin Ligase Activator Activity Regulation Of Cell Cycle Phase Transition Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Ubiquitin-protein Transferase Activity Negative Regulation Of Cell Cycle Process Nucleoplasm Regulation Of Nuclear Division Protein Polyubiquitination Proteasomal Protein Catabolic Process Mitotic Cell Cycle Phase Transition Intracellular Signal Transduction Regulation Of Mitotic Sister Chromatid Separation Cell Cycle Phase Transition Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Ubiquitin-dependent Protein Catabolic Process Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Chromosome Separation Ubiquitin-dependent Protein Catabolic Process Regulation Of Cellular Component Organization Proteolysis Regulation Of Organelle Organization Regulation Of Protein Ubiquitination Negative Regulation Of Cellular Senescence	Anaphase-promoting Complex-dependent Catabolic Process Anaphase-promoting Complex Protein K11-linked Ubiquitination Cell Division Post-translational Protein Modification Modification-dependent Protein Catabolic Process Regulation Of Meiotic Cell Cycle Proteolysis Involved In Protein Catabolic Process Protein Modification By Small Protein Conjugation Regulation Of Sister Chromatid Segregation Protein K48-linked Ubiquitination Ubiquitin-dependent Protein Catabolic Process Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Proteolysis Protein Ubiquitination Positive Regulation Of Mitotic Metaphase/anaphase Transition Regulation Of Chromosome Segregation Protein Branched Polyubiquitination Regulation Of Mitotic Sister Chromatid Separation Regulation Of Nuclear Division Positive Regulation Of Mitotic Sister Chromatid Separation Protein Polyubiquitination Proteasomal Protein Catabolic Process Macromolecule Catabolic Process Regulation Of Chromosome Separation Regulation Of Mitotic Cell Cycle Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Cell Cycle Regulation Of Reproductive Process Positive Regulation Of Ubiquitin Protein Ligase Activity Nucleoplasm Regulation Of Mitotic Metaphase/anaphase Transition Positive Regulation Of Chromosome Separation Protein Modification Process Protein Catabolic Process Regulation Of Mitotic Nuclear Division Regulation Of Chromosome Organization Positive Regulation Of Mitotic Nuclear Division Positive Regulation Of Ubiquitin-protein Transferase Activity Regulation Of Mitotic Cell Cycle Phase Transition Nucleus Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Phase Transition Catabolic Process Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Process Positive Regulation Of Cell Cycle Phase Transition Mitotic Checkpoint Complex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process
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