CTR9 and H1-2

Number of citations of the paper that reports this interaction (PubMedID 24360965)
45

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		CTR9	H1-2
Description		CTR9 component of Paf1/RNA polymerase II complex	H1.2 linker histone, cluster member
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GO Annotations	Cellular Component	Euchromatin Nucleus Nucleoplasm Cdc73/Paf1 Complex Nuclear Speck	Chromatin Nucleosome Euchromatin Nucleus Chromosome
	Molecular Function	RNA Polymerase II Complex Binding Protein Binding SH2 Domain Binding	DNA Binding Double-stranded DNA Binding RNA Binding Protein Binding Structural Constituent Of Chromatin Chromatin DNA Binding Nucleosomal DNA Binding Histone H3K27me3 Reader Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Endodermal Cell Fate Commitment Inner Cell Mass Cell Differentiation Trophectodermal Cell Differentiation Blastocyst Growth Blastocyst Hatching Chromatin Organization Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Wnt Signaling Pathway Stem Cell Population Maintenance Negative Regulation Of Myeloid Cell Differentiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Transcription By RNA Polymerase II Interleukin-6-mediated Signaling Pathway Cellular Response To Lipopolysaccharide	Negative Regulation Of Transcription By RNA Polymerase II Chromatin Organization Nucleosome Assembly Regulation Of Transcription By RNA Polymerase II Chromosome Condensation Negative Regulation Of DNA Recombination Facultative Heterochromatin Formation
Pathways		Formation of RNA Pol II elongation complex RNA Polymerase II Pre-transcription Events RNA Polymerase II Transcription Elongation E3 ubiquitin ligases ubiquitinate target proteins	Apoptosis induced DNA fragmentation Formation of Senescence-Associated Heterochromatin Foci (SAHF)
Drugs
Diseases
GWAS		Migraine ( 27182965) Sleep (1/3-day periodicity) ( 33075057)
Interacting Genes		8 interacting genes: BLK CNTNAP2 H1-2 HUNK SMAD9 SOX4 SUMO2 TCEA1	31 interacting genes: AEBP2 APP ATM CDC73 CEBPA CSNK2A2 CTNNB1 CTR9 CUL4A DDB1 F10 H3C1 IL7R IRAK4 ITCH KPNA7 KPNB1 LEO1 MRE11 NASP NCL NSD1 PAF1 PARP1 POLR2A PRKCA PRKDC PUF60 SNCA VHL WDR12
Entrez ID		9646	3006
HPRD ID		06717	07514
Ensembl ID		ENSG00000198730	ENSG00000187837
Uniprot IDs		Q6PD62	P16403
PDB IDs		5ZYQ 6GMH 6TED 7OOP 7OPC 7OPD 7UNC 7UND 8A3Y 9EGX 9EGY 9EGZ 9EH0 9EH1 9EH2	8H0V 8H0W 8KE0
Enriched GO Terms of Interacting Partners?			Nucleoplasm Endodermal Cell Fate Commitment Cell Fate Commitment Involved In Formation Of Primary Germ Layer Positive Regulation Of Macromolecule Metabolic Process Nucleus Positive Regulation Of Metabolic Process Regulation Of Macromolecule Metabolic Process Cdc73/Paf1 Complex Negative Regulation Of Macromolecule Metabolic Process Chromatin Remodeling Chromatin Organization Regulation Of Gene Expression Positive Regulation Of Biosynthetic Process Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Metabolic Process Macromolecule Metabolic Process Regulation Of Immune System Process Regulation Of Primary Metabolic Process Regulation Of Metabolic Process Regulation Of Hemopoiesis Protein-containing Complex Regulation Of Myeloid Cell Differentiation Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Regulation Of Cell Cycle Negative Regulation Of Myeloid Cell Differentiation Transcription Elongation By RNA Polymerase II Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Macromolecule Biosynthetic Process DNA-templated Transcription Elongation Negative Regulation Of Biosynthetic Process Regulation Of Apoptotic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Programmed Cell Death Stem Cell Population Maintenance Regulation Of RNA Metabolic Process Maintenance Of Cell Number Positive Regulation Of RNA Metabolic Process Regulation Of Cell Differentiation Negative Regulation Of Apoptotic Process Regulation Of Mitotic Cell Cycle Negative Regulation Of Programmed Cell Death Nucleobase-containing Compound Metabolic Process Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Enzyme Binding Cell Surface Receptor Signaling Pathway Wnt Signaling Pathway Regulation Of Signal Transduction Negative Regulation Of Transcription By RNA Polymerase II
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