CABP1 and NHERF1

		CABP1	NHERF1
Description		calcium binding protein 1	NHERF family PDZ scaffold protein 1
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GO Annotations	Cellular Component	Golgi Membrane Extracellular Space Cytoplasm Golgi Apparatus Cytoskeleton Plasma Membrane Cell Cortex Postsynaptic Density Membrane Synapse Perinuclear Region Of Cytoplasm	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex
	Molecular Function	Enzyme Inhibitor Activity Calcium Channel Regulator Activity Calcium Ion Binding Protein Binding Nuclear Localization Sequence Binding Metal Ion Binding Calcium-dependent Protein Binding	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity
	Biological Process	Visual Perception Negative Regulation Of Protein Import Into Nucleus	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway
Pathways		Sensory processing of sound by inner hair cells of the cochlea
Drugs
Diseases			Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS		C-reactive protein levels or triglyceride levels (pleiotropy) ( 27286809) Chronotype ( 30696823) Serum metabolite levels ( 33031748) Smoking initiation (ever regular vs never regular) ( 30679032) Smoking status (ever vs never smokers) ( 30643258) Systemic lupus erythematosus ( 33536424)
Interacting Genes		11 interacting genes: CACNA1A CACNA1C CSNK2A2 FOS GRK5 ITPR1 ITPR3 MPHOSPH9 NHERF1 NMT1 PPP3R1	74 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 AXIN2 BCL10 BCL2A1 BRSK2 CABP1 CD300A CDK1 CEBPA CFTR CLCN3 CNGA2 COG1 CRABP1 CTNNB1 DLGAP4 EGFR EZR GC GFI1 GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 ST6GALNAC2 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468
Entrez ID		9478	9368
HPRD ID		12025	05406
Ensembl ID		ENSG00000157782	ENSG00000109062
Uniprot IDs		C9J8G2 Q9NZU7	O14745
PDB IDs		2K7B 2K7C 2K7D 2LAN 2LAP 3OX5 3OX6	1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR
Enriched GO Terms of Interacting Partners?		Calcium Ion Transmembrane Import Into Cytosol Calcium Channel Activity Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Monoatomic Ion Channel Activity Calcium-mediated Signaling Calcium Ion Transmembrane Transport Calcineurin Complex Calcium Ion Transport Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Metal Ion Transport Inositol 1,4,5 Trisphosphate Binding High Voltage-gated Calcium Channel Activity Cytoplasm Monoatomic Cation Transport Regulation Of Sequestering Of Calcium Ion Calcium Ion Import Across Plasma Membrane Import Across Plasma Membrane Voltage-gated Calcium Channel Complex Positive Regulation Of Cytosolic Calcium Ion Concentration Calcium Ion Import Into Cytosol Intracellular Signaling Cassette Monoatomic Ion Transport Voltage-gated Calcium Channel Activity Calcium Ion Import Regulation Of Cell Communication Regulation Of Signaling Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Transmembrane Transport Monoatomic Cation Transmembrane Transport Inorganic Cation Transmembrane Transport Transport Vesicle Membrane Phosphatase Binding Wnt Signaling Pathway Medium-term Memory Cellular Response To Prolactin Release Of Sequestered Calcium Ion Into Cytosol Inositol 1,4,5-trisphosphate Receptor Activity Involved In Regulation Of Postsynaptic Cytosolic Calcium Levels Negative Regulation Of Sequestering Of Calcium Ion Myristoyltransferase Activity Renal Phosphate Ion Absorption Inorganic Ion Transmembrane Transport Protein Homotetramerization Sarcoplasmic Reticulum Monoatomic Ion Transmembrane Transport Positive Regulation Of Establishment Of Protein Localization Calcium Ion Transmembrane Transport Via High Voltage-gated Calcium Channel Signal Transduction Regulation Of Metal Ion Transport Cerebral Cortex Development	Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis
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