NHERF1 and OPRK1

Number of citations of the paper that reports this interaction (PubMedID 12004055)
0

Data Source:
HPRD (in vitro, in vivo)

		NHERF1	OPRK1
Description		NHERF family PDZ scaffold protein 1	opioid receptor kappa 1
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Nucleoplasm Mitochondrion Cytosol Plasma Membrane Membrane Sarcoplasmic Reticulum T-tubule Dendrite Synaptic Vesicle Membrane Sarcolemma Presynaptic Membrane Neuron Projection Neuronal Cell Body Perikaryon Axon Terminus Postsynaptic Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	G Protein-coupled Receptor Activity G Protein-coupled Opioid Receptor Activity Protein Binding G Protein-coupled Peptide Receptor Activity Receptor Serine/threonine Kinase Binding Dynorphin Receptor Activity Neuropeptide Binding
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Immune Response Signal Transduction G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-inhibiting G Protein-coupled Receptor Signaling Pathway Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Neuropeptide Signaling Pathway Chemical Synaptic Transmission Sensory Perception Locomotory Behavior Sensory Perception Of Pain Adenylate Cyclase-inhibiting Opioid Receptor Signaling Pathway Response To Insulin Positive Regulation Of Dopamine Secretion Negative Regulation Of Luteinizing Hormone Secretion Response To Nicotine G Protein-coupled Opioid Receptor Signaling Pathway Response To Cocaine Maternal Behavior Eating Behavior Response To Estrogen Estrous Cycle Response To Ethanol Regulation Of Saliva Secretion Behavioral Response To Cocaine Sensory Perception Of Temperature Stimulus Defense Response To Virus Cellular Response To Lipopolysaccharide Cellular Response To Glucose Stimulus Positive Regulation Of P38MAPK Cascade Positive Regulation Of Potassium Ion Transmembrane Transport Response To Acrylamide Positive Regulation Of Eating Behavior Conditioned Place Preference
Pathways			Peptide ligand-binding receptors G alpha (i) signalling events MECP2 regulates neuronal receptors and channels
Drugs			Tramadol Atomoxetine Morphine Codeine Amitriptyline Hydromorphone Mirtazapine Progesterone Meperidine Oxycodone Dextromethorphan Lamotrigine Butorphanol Dextropropoxyphene Pentazocine Naltrexone Sufentanil Fentanyl Levomenthol Loperamide Nalbuphine Levorphanol Remifentanil Buprenorphine Naloxone Dezocine Ketamine Aripiprazole 3-Methylthiofentanyl Diamorphine Etorphine Carfentanil Diprenorphine Dihydromorphine 3-Methylfentanyl V1003 Asimadoline CR665 ADL 10-0101 Mianserin Tapentadol Nalmefene Alvimopan Amisulpride Morphine glucuronide Ketobemidone Methylnaltrexone Butyrfentanyl Pholcodine Eluxadoline Opium Pentoxyverine Naldemedine Difelikefalin Samidorphan Loxicodegol
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS			Age at first sexual intercourse ( 34211149) Body size at age 10 ( 32376654) IgE levels in asthmatics (D.p. specific) ( 23967269) Modic changes ( 30808802) Systolic blood pressure x quantitative lifestyle risk score interaction (2df test) ( 32227373)
Interacting Genes		74 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 AXIN2 BCL10 BCL2A1 BRSK2 CABP1 CD300A CDK1 CEBPA CFTR CLCN3 CNGA2 COG1 CRABP1 CTNNB1 DLGAP4 EGFR EZR GC GFI1 GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 ST6GALNAC2 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	6 interacting genes: GABARAPL1 GNA15 GPRASP1 NHERF1 NKG7 OPRD1
Entrez ID		9368	4986
HPRD ID		05406	01309
Ensembl ID		ENSG00000109062	ENSG00000082556
Uniprot IDs		O14745	A0A5F9ZI09 P41145
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR	4DJH 6B73 6VI4 7T10 7T11 7UL2 7UL3 7UL5 7Y1F 7YIT 7YMJ 8DZP 8DZQ 8DZR 8DZS 8F7W 8FEG 8HNN 8K2W 8VVE 8VVF 8VVG 9D61
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Natural Killer Cell Mediated Cytotoxicity Directed Against Tumor Cell Target G Protein-coupled Enkephalin Receptor Activity Renal Phosphate Ion Absorption Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding G Protein-coupled Receptor Catabolic Process Phospholipase C-activating G Protein-coupled Acetylcholine Receptor Signaling Pathway G Protein-coupled Receptor Signaling Pathway Natural Killer Cell Degranulation Cytolytic Granule Membrane Immune Response To Tumor Cell Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Vesicle Receptor Serine/threonine Kinase Binding G Protein-coupled Opioid Receptor Activity Spine Apparatus Microvillus Organization Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Type 3 Metabotropic Glutamate Receptor Binding Establishment Of Golgi Localization Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Phospholipase C-activating Dopamine Receptor Signaling Pathway Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Growth Factor Receptor Binding G Protein-coupled Opioid Receptor Signaling Pathway Intracellular Phosphate Ion Homeostasis Cytolytic Granule Granzyme-mediated Programmed Cell Death Signaling Pathway Cellular Response To Toxic Substance Negative Regulation Of Sodium Ion Transport Gamma-aminobutyric Acid Transport Golgi Localization Maintenance Of Cell Polarity Glutathione Transport Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Negative Regulation Of Fibroblast Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Cerebrospinal Fluid Circulation Phosphatidylethanolamine Binding Cellular Response To Nitrogen Starvation Tat Protein Binding Glycophagy Plasma Membrane Protein Complex
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