NHERF1 and ABCC4

Number of citations of the paper that reports this interaction (PubMedID 18559527)
0

Data Source:
BioGRID (pull down)

		NHERF1	ABCC4
Description		NHERF family PDZ scaffold protein 1	ATP binding cassette subfamily C member 4 (PEL blood group)
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Nucleolus Golgi Apparatus Plasma Membrane Membrane Basolateral Plasma Membrane Apical Plasma Membrane Platelet Dense Granule Membrane External Side Of Apical Plasma Membrane
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	Nucleotide Binding Guanine Nucleotide Transmembrane Transporter Activity Protein Binding ATP Binding ABC-type Xenobiotic Transporter Activity Prostaglandin Transmembrane Transporter Activity Urate Transmembrane Transporter Activity Purine Nucleotide Transmembrane Transporter Activity ABC-type Glutathione S-conjugate Transporter Activity ABC-type Bile Acid Transporter Activity Efflux Transmembrane Transporter Activity 15-hydroxyprostaglandin Dehydrogenase (NAD+) Activity ATP Hydrolysis Activity Glutathione Transmembrane Transporter Activity ATPase-coupled Transmembrane Transporter Activity Xenobiotic Transmembrane Transporter Activity ATPase-coupled Inorganic Anion Transmembrane Transporter Activity ABC-type Transporter Activity
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Platelet Degranulation Xenobiotic Metabolic Process Xenobiotic Transmembrane Transport Lipid Transport Bile Acid And Bile Salt Transport Prostaglandin Transport Urate Transport Prostaglandin Secretion Glutathione Transmembrane Transport Transmembrane Transport Cilium Assembly CAMP Transport Leukotriene Transport Monoatomic Anion Transmembrane Transport Export Across Plasma Membrane Transport Across Blood-brain Barrier Guanine Nucleotide Transmembrane Transport
Pathways			Platelet degranulation ABC-family proteins mediated transport Azathioprine ADME Paracetamol ADME
Drugs			ATP
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS			Acute post-radiotherapy pain in breast cancer ( 31196165) Airway responsiveness in chronic obstructive pulmonary disease ( 25514360) Breast cancer ( 17903305) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223) Longevity ( 20834067) Parent of origin effect on language impairment (paternal) ( 24571439) Platelet count ( 22139419 27863252 29403010 32888494) Plateletcrit ( 27863252 32888494) Postherpetic neuralgia ( 33685280) Response to irinotecan and platinum-based chemotherapy in non-small-cell lung cancer ( 23478653) Serum metabolite levels ( 33031748)
Interacting Genes		74 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 AXIN2 BCL10 BCL2A1 BRSK2 CABP1 CD300A CDK1 CEBPA CFTR CLCN3 CNGA2 COG1 CRABP1 CTNNB1 DLGAP4 EGFR EZR GC GFI1 GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 ST6GALNAC2 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	6 interacting genes: ERBIN MPP1 NHERF1 NHERF2 PDZK1 SNTA1
Entrez ID		9368	10257
HPRD ID		05406	05583
Ensembl ID		ENSG00000109062	ENSG00000125257
Uniprot IDs		O14745	A8K2Q2 O15439
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR	8BJF 8BWO 8BWP 8BWQ 8BWR 8I4A 8I4B 8I4C 8IZ7 8IZ8 8IZ9 8IZA 8J3W 8J3Z 8XOK 8XOL 8XOM
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Signaling Receptor Binding Protein-membrane Adaptor Activity Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding PDZ Domain Binding Protein Localization To Plasma Membrane Microvillus Membrane Protein Localization To Cell Periphery Stereocilium Protein Localization To Membrane Brush Border Membrane Phosphatase Binding Establishment Or Maintenance Of Apical/basal Cell Polarity Establishment Or Maintenance Of Epithelial Cell Apical/basal Polarity Apical Plasma Membrane Regulation Of Sodium Ion Transport Regulation Of Monoatomic Ion Transport Plasma Membrane Neuromuscular Junction Renal Phosphate Ion Absorption Localization Within Membrane Beta-catenin Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Basal Protein Localization ErbB-2 Class Receptor Binding Intracellular Protein Localization Scavenger Receptor Binding Syntrophin Complex Establishment Or Maintenance Of Cell Polarity Negative Regulation Of Nucleotide-binding Oligomerization Domain Containing 2 Signaling Pathway Molecular Adaptor Activity Growth Factor Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity Beta-2 Adrenergic Receptor Binding Chloride Channel Regulator Activity Gamma-aminobutyric Acid Import Negative Regulation Of Monocyte Chemotactic Protein-1 Production Microvillus Organization Establishment Of Golgi Localization Phospholipase C-activating Dopamine Receptor Signaling Pathway Hemidesmosome GMP Kinase Activity Intracellular Phosphate Ion Homeostasis
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