NHERF1 and SLC22A11

Number of citations of the paper that reports this interaction (PubMedID 16236806)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		NHERF1	SLC22A11
Description		NHERF family PDZ scaffold protein 1	solute carrier family 22 member 11
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GO Annotations	Cellular Component	Ruffle Nucleus Cytoplasm Plasma Membrane Microvillus Endomembrane System Actin Cytoskeleton Membrane Apical Plasma Membrane Filopodium Brush Border Membrane Microvillus Membrane Vesicle Stereocilium Stereocilium Tip Cell Projection Apical Part Of Cell Perinuclear Region Of Cytoplasm Extracellular Exosome Cell Periphery Sperm Midpiece Plasma Membrane Protein Complex	Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Signaling Receptor Binding Protein Binding Beta-catenin Binding Gamma-aminobutyric Acid Transmembrane Transporter Activity Chloride Channel Regulator Activity Phosphatase Binding PDZ Domain Binding Beta-2 Adrenergic Receptor Binding Type 2 Metabotropic Glutamate Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Identical Protein Binding Protein-membrane Adaptor Activity Dopamine Receptor Binding Molecular Adaptor Activity Growth Factor Receptor Binding Channel Activator Activity	Solute:inorganic Anion Antiporter Activity Protein Binding Organic Anion Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Antiporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Morphogenesis Of An Epithelium Renal Sodium Ion Transport Sodium Ion Transport Plasma Membrane Organization Nuclear Migration Adenylate Cyclase-activating Dopamine Receptor Signaling Pathway Sensory Perception Of Sound Intracellular Protein Localization Negative Regulation Of Cell Population Proliferation Regulation Of Cell Shape Regulation Of Cell Size Negative Regulation Of Platelet-derived Growth Factor Receptor Signaling Pathway Fibroblast Migration Negative Regulation Of Fibroblast Migration Negative Regulation Of Sodium Ion Transport Wnt Signaling Pathway Gland Morphogenesis Microvillus Assembly Actin Cytoskeleton Organization Intracellular Phosphate Ion Homeostasis Bile Acid Secretion Glutathione Transport Cilium Organization Establishment Of Epithelial Cell Apical/basal Polarity Maintenance Of Epithelial Cell Apical/basal Polarity Regulation Of Protein Kinase Activity Negative Regulation Of Mitotic Cell Cycle Establishment Of Localization In Cell Establishment Of Golgi Localization Negative Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Gamma-aminobutyric Acid Import Auditory Receptor Cell Stereocilium Organization Phospholipase C-activating Dopamine Receptor Signaling Pathway Protein-containing Complex Assembly Renal Absorption Negative Regulation Of ERK1 And ERK2 Cascade Protein Localization To Plasma Membrane Negative Regulation Of Canonical Wnt Signaling Pathway Cerebrospinal Fluid Circulation Renal Phosphate Ion Absorption Import Across Plasma Membrane Transport Across Blood-brain Barrier Regulation Of Renal Phosphate Excretion Negative Regulation Of Cell Motility Positive Regulation Of Intrinsic Apoptotic Signaling Pathway	Monoatomic Ion Transport Inorganic Anion Transport Organic Anion Transport Prostaglandin Transport Urate Metabolic Process Transmembrane Transport
Pathways			Organic anion transport by SLC22 transporters
Drugs			Cefotaxime Probenecid Ceftriaxone Lesinurad
Diseases		Nephrolithiasis/osteoporosis, hypophosphatemic
GWAS			Body mass index ( 32363570) Gout ( 33832965 32238385) Gout vs asymptomatic hyperuricemia ( 33832965) Obesity-related traits ( 23251661) Renal underexcretion gout ( 32238385) Serum uric acid levels ( 26902266 30993211) Systemic lupus erythematosus ( 28714469) Urate levels ( 20884846 31578528 23263486) Urate levels in lean individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		74 interacting genes: ABCC2 ABCC4 ACE2 ADRB2 AKAP10 AKT1 APPBP2 ATP6V1B1 ATP6V1E1 AXIN2 BCL10 BCL2A1 BRSK2 CABP1 CD300A CDK1 CEBPA CFTR CLCN3 CNGA2 COG1 CRABP1 CTNNB1 DLGAP4 EGFR EZR GC GFI1 GNA11 GNAQ GRK6 KCNJ1 LHCGR LPAR2 MSN NF2 NOS2 OGT OPRK1 P2RY1 PAG1 PDGFRA PDGFRB PHLPP1 PIN1 PLCB1 PLCB2 PRKCA PTEN PTH1R RDX RLBP1 SCN4A SKP2 SLC13A1 SLC22A11 SLC22A4 SLC22A5 SLC22A9 SLC26A3 SLC34A1 SLC4A7 SLC4A8 SLC9A3 SLCO1A2 SLCO3A1 ST6GALNAC2 TBC1D10A TRPC4 TRPC5 UBE3A YAP1 YES1 ZNF468	3 interacting genes: CAV3 NHERF1 PDZK1
Entrez ID		9368	55867
HPRD ID		05406	06161
Ensembl ID		ENSG00000109062	ENSG00000168065
Uniprot IDs		O14745	Q9NSA0
PDB IDs		1G9O 1GQ4 1GQ5 1I92 1SGH 2D10 2JXO 2KJD 2KRG 2M0T 2M0U 2M0V 2OZF 4JL7 4LMM 4MPA 4N6X 4PQW 4Q3H 6RQR	8WJH
Enriched GO Terms of Interacting Partners?		Apical Plasma Membrane Plasma Membrane Monoatomic Ion Transport Transmembrane Transport Basolateral Plasma Membrane Regulation Of Biological Quality Membrane Sodium Ion Transport Organic Anion Transport Monoatomic Ion Transmembrane Transport PDZ Domain Binding System Process Monoatomic Cation Transport Metal Ion Transport Cellular Response To Oxygen-containing Compound Inorganic Ion Transmembrane Transport Carboxylic Acid Transport Organic Acid Transport Cellular Homeostasis Regulation Of MAPK Cascade Homeostatic Process Regulation Of Intracellular PH Regulation Of Cellular PH Regulation Of Transport Response To Lipid Inorganic Cation Transmembrane Transport Regulation Of Protein Localization Intracellular Chemical Homeostasis Monoatomic Cation Transmembrane Transport Regulation Of PH Organic Anion Transmembrane Transporter Activity Microvillus Positive Regulation Of Early Endosome To Late Endosome Transport Positive Regulation Of Protein Metabolic Process Positive Regulation Of Protein Localization Phospholipase C-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Localization To Early Endosome Sodium-independent Organic Anion Transmembrane Transporter Activity Monoatomic Anion Transmembrane Transport Monocarboxylic Acid Transport Chemical Homeostasis Enzyme Binding Regulation Of Signaling Regulation Of Cell Communication Intracellular Monoatomic Cation Homeostasis Solute:inorganic Anion Antiporter Activity Positive Regulation Of Protein Localization To Endosome Inorganic Anion Transport Monoatomic Anion Transport Intracellular Monoatomic Ion Homeostasis	Protein Localization To Cell Periphery Protein Localization To Plasma Membrane Regulation Of Monoatomic Ion Transport Nucleus Localization Protein Localization To Membrane Microvillus Membrane Protein-membrane Adaptor Activity Localization Within Membrane Brush Border Membrane Regulation Of Sodium Ion Transport Regulation Of Cell Size PDZ Domain Binding Negative Regulation Of Monoatomic Ion Transport Plasma Membrane Organization Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of Sarcomere Organization Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Renal Phosphate Ion Absorption Negative Regulation Of MAPK Cascade Molecular Adaptor Activity Vesicle Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Caveolin-mediated Endocytosis Detection Of Muscle Stretch Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Localization Regulation Of Metal Ion Transport Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cellular Component Size Intracellular Protein Localization Regulation Of Transport Regulation Of Membrane Depolarization During Action Potential T-tubule Organization Cellular Response To Ionomycin Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity
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