SLC22A11

Description		solute carrier family 22 member 11
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Basal Plasma Membrane Membrane Apical Plasma Membrane Extracellular Exosome
	Molecular Function	Solute:inorganic Anion Antiporter Activity Protein Binding Organic Anion Transmembrane Transporter Activity Prostaglandin Transmembrane Transporter Activity Antiporter Activity Sodium-independent Organic Anion Transmembrane Transporter Activity Transmembrane Transporter Activity
	Biological Process	Monoatomic Ion Transport Inorganic Anion Transport Organic Anion Transport Prostaglandin Transport Urate Metabolic Process Transmembrane Transport
Pathways		Organic anion transport by SLC22 transporters
Drugs		Cefotaxime Probenecid Ceftriaxone Lesinurad
Diseases
GWAS		Body mass index ( 32363570) Gout ( 33832965 32238385) Gout vs asymptomatic hyperuricemia ( 33832965) Obesity-related traits ( 23251661) Renal underexcretion gout ( 32238385) Serum uric acid levels ( 26902266 30993211) Systemic lupus erythematosus ( 28714469) Urate levels ( 20884846 31578528 23263486) Urate levels in lean individuals ( 25811787) Urate levels in overweight individuals ( 25811787) Uric acid levels ( 19503597) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Novel Interacting Genes		3 novel interacting genes: CAV3 NHERF1 PDZK1
Interacting Genes		3 interacting genes: CAV3 NHERF1 PDZK1
Entrez ID		55867
HPRD ID		06161
Ensembl ID		ENSG00000168065
Uniprot IDs		Q9NSA0
PDB IDs		8WJH
Enriched GO Terms of Interacting Partners?		Protein Localization To Cell Periphery Protein Localization To Plasma Membrane Regulation Of Monoatomic Ion Transport Nucleus Localization Protein Localization To Membrane Microvillus Membrane Protein-membrane Adaptor Activity Localization Within Membrane Brush Border Membrane Regulation Of Sodium Ion Transport Regulation Of Cell Size PDZ Domain Binding Negative Regulation Of Monoatomic Ion Transport Plasma Membrane Organization Regulation Of Nerve Growth Factor Receptor Activity Negative Regulation Of Sarcomere Organization Regulation Of Signal Transduction By Receptor Internalization Negative Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Renal Phosphate Ion Absorption Negative Regulation Of MAPK Cascade Molecular Adaptor Activity Vesicle Type 2 Metabotropic Glutamate Receptor Binding Regulation Of Renal Phosphate Excretion Dopamine Receptor Binding Type 3 Metabotropic Glutamate Receptor Binding Regulation Of Ventricular Cardiac Muscle Cell Membrane Depolarization Regulation Of Caveolin-mediated Endocytosis Connexin Binding Positive Regulation Of Caveolin-mediated Endocytosis Detection Of Muscle Stretch Regulation Of Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Cellular Localization Regulation Of Metal Ion Transport Regulation Of Branching Involved In Mammary Gland Duct Morphogenesis Regulation Of Cellular Component Size Intracellular Protein Localization Regulation Of Transport Regulation Of Membrane Depolarization During Action Potential T-tubule Organization Cellular Response To Ionomycin Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Scavenger Receptor Binding Carnitine Transmembrane Transport Carnitine Transport Maintenance Of Epithelial Cell Apical/basal Polarity Bile Acid Secretion Microvillus Assembly Channel Activator Activity Gamma-aminobutyric Acid Transmembrane Transporter Activity
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