CD5 and CTTN

		CD5	CTTN
Description		CD5 molecule	cortactin
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GO Annotations	Cellular Component	Plasma Membrane External Side Of Plasma Membrane Membrane	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone
	Molecular Function	Protein Binding Signaling Receptor Activity	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding
	Biological Process	Cell Recognition T Cell Costimulation Apoptotic Signaling Pathway	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway
Pathways			RHO GTPases activate PAKs Clathrin-mediated endocytosis
Drugs
Diseases
GWAS		Coffee consumption ( 31046077) Gut microbiota (bacterial taxa) ( 27694959) Gut microbiota (functional units) ( 27694959) Inflammatory bowel disease ( 23128233) Multiple sclerosis ( 21833088 24076602) Rheumatoid arthritis ( 23143596 24390342 30423114) Rheumatoid arthritis (ACPA-positive) ( 23143596 24532676) Systolic blood pressure x smoking status (current vs non-current) interaction (2df test) ( 29455858) Systolic blood pressure x smoking status (ever vs never) interaction (2df test) ( 29455858)
Interacting Genes		27 interacting genes: CAMK2D CAPN1 CBL CD2 CD247 CD4 CD6 CD72 CD79A CD79B CFL1 CSNK2A1 CTTN DNASE1L2 DYNLT3 FYN HNRNPU LCK MX1 PIK3R1 PRKCA PRKCB PRKCG PTPN6 RASA1 ZAP70 ZNHIT2	59 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CD5 CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3
Entrez ID		921	2017
HPRD ID		01078	01268
Ensembl ID		ENSG00000110448	ENSG00000085733
Uniprot IDs		P06127	Q14247 Q53HG7
PDB IDs		2JA4 2JOP 2JP0 2OTT	1X69 2D1X
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Signaling Pathway Lymphocyte Activation Antigen Receptor-mediated Signaling Pathway Phosphotyrosine Residue Binding Plasma Membrane Leukocyte Activation Signal Transduction Positive Regulation Of Immune System Process Cell Activation Immune Response-activating Cell Surface Receptor Signaling Pathway Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Immune Response-regulating Cell Surface Receptor Signaling Pathway T Cell Activation Adaptive Immune Response Regulation Of Immune System Process T Cell Receptor Complex B Cell Receptor Signaling Pathway Cell-cell Junction Immune Response-activating Signaling Pathway Immune Response Regulation Of Immune Response Signaling Receptor Binding Immune System Process Immune Response-regulating Signaling Pathway Activation Of Immune Response Regulation Of Cell Adhesion Positive Regulation Of Multicellular Organismal Process Positive Regulation Of Immune Response Regulation Of Apoptotic Process Protein Kinase Activity Identical Protein Binding T Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Regulation Of Programmed Cell Death Protein Phosphorylation Intracellular Signal Transduction Membrane Raft Peptidyl-tyrosine Phosphorylation Phosphorylation Regulation Of T Cell Activation Positive Regulation Of Cell Activation Lymphocyte Differentiation Phosphatidylinositol 3-kinase Binding Histone H3T6 Kinase Activity Diacylglycerol-dependent Serine/threonine Kinase Activity Positive Regulation Of T Cell Activation Kinase Activity Regulation Of Hemopoiesis Negative Regulation Of Apoptotic Process Positive Regulation Of Leukocyte Cell-cell Adhesion	SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization
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