CTTN and FGD1

Number of citations of the paper that reports this interaction (PubMedID 12913069)
0

Data Source:
HPRD (in vitro)

		CTTN	FGD1
Description		cortactin	FYVE, RhoGEF and PH domain containing 1
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone	Ruffle Cytoplasm Golgi Apparatus Cytosol Cytoskeleton Plasma Membrane Lamellipodium Cell Projection
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding	Guanyl-nucleotide Exchange Factor Activity Zinc Ion Binding Small GTPase Binding Metal Ion Binding
	Biological Process	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Cytoskeleton Organization Signal Transduction Regulation Of Cell Shape Animal Organ Morphogenesis Actin Cytoskeleton Organization Regulation Of GTPase Activity Filopodium Assembly Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis	NRAGE signals death through JNK G alpha (12/13) signalling events CDC42 GTPase cycle
Drugs
Diseases			Aarskog-Scott syndrome; Faciogenital dysplasia
GWAS			Prostate cancer ( 31562322)
Interacting Genes		58 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3	5 interacting genes: AOC1 CDC42 CTTN ELMO1 SH3RF1
Entrez ID		2017	2245
HPRD ID		01268	02373
Ensembl ID		ENSG00000085733	ENSG00000102302
Uniprot IDs		Q14247 Q53HG7	P98174
PDB IDs		1X69 2D1X
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization	Neuron Projection Organization Dendritic Spine Organization Postsynapse Organization Phagocytosis, Engulfment Membrane Invagination Cell Motility Postsynapse Actin Cytoskeleton Organization Actin Filament-based Process Endocytosis Diamine Oxidase Activity Putrescine Oxidase Activity Histamine Oxidase Activity Glutamatergic Synapse Negative Regulation Of Extrinsic Apoptotic Signaling Pathway Import Into Cell GBD Domain Binding Storage Vacuole Regulation Of Postsynapse Organization Endothelin Receptor Signaling Pathway Involved In Heart Process Regulation Of Extrinsic Apoptotic Signaling Pathway Positive Regulation Of Supramolecular Fiber Organization Apolipoprotein A-I Receptor Binding Intracellular Signaling Cassette Neuropilin Signaling Pathway Positive Regulation Of Cytoskeleton Organization Lamellipodium Quinone Binding Primary Methylamine Oxidase Activity Putrescine Metabolic Process Leading Edge Membrane Regulation Of Cell Projection Assembly Thioesterase Binding Cell Projection Morphogenesis Positive Regulation Of Pinocytosis Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis G Protein-coupled Receptor Signaling Pathway Involved In Heart Process Regulation Of Actin Filament Organization Vesicle-mediated Transport Actin Filament Organization Cytoskeleton Organization Small GTPase-mediated Signal Transduction Cell Junction Assembly Neuron Fate Determination Cardiac Neural Crest Cell Migration Involved In Outflow Tract Morphogenesis Establishment Of Golgi Localization Neuron Projection Morphogenesis Golgi Transport Complex Positive Regulation Of Epithelial Cell Proliferation Involved In Lung Morphogenesis Profilin Binding
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