CTTN and ARHGAP17

Number of citations of the paper that reports this interaction (PubMedID 11431473)
0

Data Source:
HPRD (in vitro)

		CTTN	ARHGAP17
Description		cortactin	Rho GTPase activating protein 17
Image			No pdb structure
GO Annotations	Cellular Component	Ruffle Podosome Cytoplasm Endoplasmic Reticulum Golgi Apparatus Cytosol Cytoskeleton Actin Filament Plasma Membrane Clathrin-coated Pit Focal Adhesion Cell Cortex Voltage-gated Potassium Channel Complex Membrane Lamellipodium Cell Junction Endocytic Vesicle Dendrite Growth Cone Cortical Cytoskeleton Cell Projection Dendritic Spine Synapse Anchoring Junction Postsynapse Postsynaptic Actin Cytoskeleton Glutamatergic Synapse Mitotic Spindle Midzone	Cytoplasm Cytosol Plasma Membrane Bicellular Tight Junction Membrane Anchoring Junction
	Molecular Function	Protein Binding Profilin Binding Cadherin Binding Proline-rich Region Binding Arp2/3 Complex Binding	GTPase Activator Activity Protein Binding SH3 Domain Binding
	Biological Process	Intracellular Protein Transport Endocytosis Receptor-mediated Endocytosis Substrate-dependent Cell Migration, Cell Extension Signal Transduction Actin Cytoskeleton Organization Regulation Of Axon Extension Positive Regulation Of Actin Filament Polymerization Positive Regulation Of Smooth Muscle Contraction Focal Adhesion Assembly Neuron Projection Morphogenesis Cell Motility Positive Regulation Of Chemotaxis Regulation Of Cell Projection Assembly Dendritic Spine Maintenance Extrinsic Apoptotic Signaling Pathway Lamellipodium Organization Modification Of Postsynaptic Actin Cytoskeleton Modification Of Postsynaptic Structure Regulation Of Mitophagy Negative Regulation Of Extrinsic Apoptotic Signaling Pathway	Signal Transduction Regulation Of Actin Cytoskeleton Organization Regulation Of Rac Protein Signal Transduction Negative Regulation Of Small GTPase Mediated Signal Transduction
Pathways		RHO GTPases activate PAKs Clathrin-mediated endocytosis	CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RAC3 GTPase cycle
Drugs
Diseases
GWAS			Appendicular lean mass ( 33097823) Gut microbiota (bacterial taxa, rank normal transformation method) ( 32572223)
Interacting Genes		59 interacting genes: ACD ACTA1 ACTG1 ACTR3 ANKZF1 ARHGAP17 ARHGAP8 ATM CASP3 CD2AP CD5 CHD3 CPSF7 CTNND1 CTNND2 CTTNBP2 DNM1 DNM2 EGFR FER FGD1 GRB2 GRIA2 GTSE1 HAX1 HIP1R KCNA2 KEAP1 MET MYLK NHSL2 NXF1 PRPF6 RBM15 RPL23A RPL37 RPL9 RSPH1 SDC3 SF1 SF3B4 SFPQ SH3BP2 SHANK2 SHANK3 SIRT1 SMURF1 SPRR2A SRC SYK TINF2 TJP1 TNK2 TRIM15 USP7 WASL WIPF1 YTHDF1 YTHDF3	16 interacting genes: ABL1 APP BTK CDC42 CRK CTTN DNMBP FNBP1 GRB2 LCK PACSIN1 PIK3R1 RAC1 SH3GLB1 SRC TRIP10
Entrez ID		2017	55114
HPRD ID		01268	12207
Ensembl ID		ENSG00000085733	ENSG00000140750
Uniprot IDs		Q14247 Q53HG7	Q68EM7
PDB IDs		1X69 2D1X
Enriched GO Terms of Interacting Partners?		SH3 Domain Binding Cellular Component Assembly Cytoplasm Regulation Of Cellular Component Organization Anchoring Junction Lamellipodium Regulation Of Actin Cytoskeleton Organization Regulation Of Organelle Organization Actin Cytoskeleton Actin Filament Regulation Of Actin Filament-based Process Cytosol Organelle Organization Actin Filament Organization Regulation Of Actin Filament Organization Cellular Response To Chemical Stress Protein Tyrosine Kinase Activity Positive Regulation Of Protein-containing Complex Assembly Positive Regulation Of Metabolic Process Negative Regulation Of Telomere Maintenance Actin Filament-based Process Regulation Of Cytoskeleton Organization Vesicle Scission Negative Regulation Of Membrane Tubulation Podosome Grb2-EGFR Complex Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of TOR Signaling Cell Projection Non-membrane Spanning Protein Tyrosine Kinase Activity Regulation Of Vesicle-mediated Transport Postsynapse Organization Response To Reactive Oxygen Species Regulation Of Chromosome Organization Positive Regulation Of Cellular Component Organization Cytoskeleton Regulation Of Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Postsynaptic Density Regulation Of Signal Transduction Actin Cytoskeleton Organization Dendritic Spine Morphogenesis Regulation Of Clathrin-dependent Endocytosis Response To Oxidative Stress Positive Regulation Of Platelet-derived Growth Factor Receptor-beta Signaling Pathway Regulation Of Telomere Maintenance Cellular Response To Reactive Oxygen Species Regulation Of Autophagy Regulation Of Supramolecular Fiber Organization	Ephrin Receptor Binding Endocytosis Positive Regulation Of Cellular Component Biogenesis Positive Regulation Of Cellular Component Organization Actin Cytoskeleton Organization Phosphotyrosine Residue Binding Import Into Cell Actin Filament-based Process Regulation Of Protein-containing Complex Assembly Regulation Of Cell Projection Organization Regulation Of Endocytosis Positive Regulation Of Supramolecular Fiber Organization Cytosol Regulation Of Actin Cytoskeleton Organization Positive Regulation Of Protein-containing Complex Assembly Cell-cell Junction Positive Regulation Of Locomotion Regulation Of Actin Filament-based Process Positive Regulation Of Lamellipodium Organization Regulation Of Supramolecular Fiber Organization Regulation Of Cell-substrate Adhesion Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of MAPK Cascade SH2 Domain Binding Cytoskeleton Organization Positive Regulation Of Substrate Adhesion-dependent Cell Spreading Non-membrane Spanning Protein Tyrosine Kinase Activity Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Regulation Of Cellular Component Organization Substrate Adhesion-dependent Cell Spreading Regulation Of Actin Filament Organization Phospholipase Activator Activity Cell Surface Receptor Signaling Pathway Regulation Of Intracellular Signal Transduction Regulation Of Lamellipodium Organization B Cell Receptor Signaling Pathway Positive Regulation Of Cell Adhesion Positive Regulation Of Organelle Organization Positive Regulation Of Intracellular Signal Transduction Fc Receptor Signaling Pathway Regulation Of Cell Adhesion Vesicle-mediated Transport Regulation Of Cytoskeleton Organization Regulation Of Substrate Adhesion-dependent Cell Spreading Signal Transduction Regulation Of Organelle Organization Regulation Of Vesicle-mediated Transport Positive Regulation Of Cell Migration Leukocyte Activation Positive Regulation Of Cell Motility
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