AP4M1 and USP47

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		AP4M1	USP47
Description		adaptor related protein complex 4 subunit mu 1	ubiquitin specific peptidase 47
Image			No pdb structure
GO Annotations	Cellular Component	Cytoplasm Endosome Early Endosome Golgi Apparatus Trans-Golgi Network Cytosol Membrane AP-4 Adaptor Complex Clathrin Adaptor Complex Cytoplasmic Vesicle Endosome Lumen Trans-Golgi Network Membrane Extracellular Exosome	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex
	Molecular Function	Protein Binding Protein Transmembrane Transporter Activity Protein Domain Specific Binding	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity WD40-repeat Domain Binding Deubiquitinase Activity
	Biological Process	Autophagosome Assembly Protein Targeting Protein Targeting To Lysosome Intracellular Protein Transport Post-Golgi Vesicle-mediated Transport Golgi To Endosome Transport Intracellular Protein Localization Protein Transport Vesicle-mediated Transport Protein Transmembrane Transport Golgi To Lysosome Transport Protein Localization To Basolateral Plasma Membrane	DNA Repair Base-excision Repair Proteolysis DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Deubiquitination Regulation Of Protein Stability Monoubiquitinated Protein Deubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage
Pathways		Lysosome Vesicle Biogenesis	Ub-specific processing proteases
Drugs
Diseases		Cerebral palsy
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Waist circumference adjusted for body mass index ( 28552196)
Interacting Genes		17 interacting genes: ARF1 CACNG3 CD63 CHTF8 DDX52 FNTA GRID2 GRIN2A GRIN2B HOOK1 HOOK2 KRTAP5-2 LAMP2 PMPCB TGOLN2 USP47 ZBTB22	9 interacting genes: AP4M1 DSCR9 MED29 MED9 PLA2G2A RPS2 SNCA TLE3 UBC
Entrez ID		9179	55031
HPRD ID		03803	11668
Ensembl ID		ENSG00000221838	ENSG00000170242
Uniprot IDs		C9JC87 C9JWL4 H7C0A0 O00189	Q96K76
PDB IDs		3L81 4MDR
Enriched GO Terms of Interacting Partners?		Postsynaptic Density Membrane Ligand-gated Monoatomic Ion Channel Activity Ionotropic Glutamate Receptor Signaling Pathway Positive Regulation Of Synaptic Transmission, Glutamatergic Ligand-gated Ion Channel Signaling Pathway Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential FHF Complex Synaptic Transmission, Glutamatergic Intracellular Protein Localization Platelet Dense Granule Membrane Glutamate Receptor Signaling Pathway NMDA Glutamate Receptor Activity Protein Localization To Perinuclear Region Of Cytoplasm Excitatory Postsynaptic Potential NMDA Selective Glutamate Receptor Complex Glutamate-gated Calcium Ion Channel Activity Calcium Ion Transmembrane Transport Regulation Of Synaptic Plasticity Excitatory Chemical Synaptic Transmission Cellular Localization Regulation Of Synaptic Transmission, Glutamatergic Monoatomic Ion Transmembrane Transport Calcium Ion Transport HOPS Complex Modulation Of Chemical Synaptic Transmission Somatodendritic Compartment Regulation Of Postsynaptic Membrane Potential Monoatomic Ion Transport Lysosomal Transport Inorganic Cation Transmembrane Transport Early Endosome To Late Endosome Transport Monoatomic Cation Transmembrane Transport AMPA Glutamate Receptor Complex Dynein Light Intermediate Chain Binding Positive Regulation Of Synaptic Transmission Late Endosome Protein Localization To Postsynaptic Membrane Positive Regulation Of Excitatory Postsynaptic Potential Inorganic Ion Transmembrane Transport Protein Localization To Postsynapse Transmembrane Transport Monoatomic Ion Channel Activity Vacuolar Transport Monoatomic Cation Transport Trans-Golgi Network Mitotic Cleavage Furrow Ingression Pigment Granule Maturation Peptide Pheromone Maturation Chaperone-mediated Autophagy Translocation Complex Establishment Of Protein Localization	Mitochondrial Outer Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Mediator Complex Core Mediator Complex Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Protein Localization To Basolateral Plasma Membrane Regulation Of DNA-templated Transcription Elongation Phospholipid Binding Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake AP-4 Adaptor Complex Transcription Coregulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process
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