USP47 and TLE3

Number of citations of the paper that reports this interaction (PubMedID 36749823)
53

Data Source:
BioGRID (enzymatic study)

		USP47	TLE3
Description		ubiquitin specific peptidase 47	TLE family member 3, transcriptional corepressor
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Cytosol SCF Ubiquitin Ligase Complex	Nucleus Nucleoplasm Transcription Regulator Complex Beta-catenin-TCF Complex
	Molecular Function	Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity WD40-repeat Domain Binding Deubiquitinase Activity	Transcription Corepressor Activity Protein Binding
	Biological Process	DNA Repair Base-excision Repair Proteolysis DNA Damage Response Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage Protein Deubiquitination Regulation Of Protein Stability Monoubiquitinated Protein Deubiquitination Positive Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Intrinsic Apoptotic Signaling Pathway In Response To DNA Damage	Regulation Of DNA-templated Transcription Signal Transduction Animal Organ Morphogenesis Wnt Signaling Pathway Negative Regulation Of DNA-templated Transcription Negative Regulation Of Canonical Wnt Signaling Pathway Negative Regulation Of Cold-induced Thermogenesis
Pathways		Ub-specific processing proteases	Formation of the beta-catenin:TCF transactivating complex Deactivation of the beta-catenin transactivating complex Repression of WNT target genes Repression of WNT target genes Estrogen-dependent gene expression
Drugs
Diseases
GWAS		Waist circumference adjusted for body mass index ( 28552196)	Alcoholic chronic pancreatitis ( 28754779) Atrial fibrillation ( 29892015) Cognitive function ( 24684796) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Eosinophil count ( 32888494) Eosinophil percentage of white cells ( 32888494) Heel bone mineral density ( 30598549 28869591) Height ( 20881960 31562340 28552196 25282103) Hip circumference adjusted for BMI ( 34021172) L-selectin levels ( 25576479) Lumbar spine bone mineral density (integral) ( 27476799) Lung adenocarcinoma ( 28604730) Macular thickness ( 30535121) Male-pattern baldness ( 27182965) Monocyte percentage of white cells ( 32888494) Non-albumin protein levels ( 29403010) Non-response to citalopram or escitalopram and depression ( 27622933) PR interval ( 32439900 30046033) Pulmonary function ( 23932459) Red blood cell count ( 32888494) Rheumatoid arthritis ( 23143596) Rheumatoid arthritis (ACPA-positive) ( 24532676 23143596) Schizophrenia ( 30285260 29483656 25056061) Serum total protein levels ( 29403010) Triglyceride levels ( 29403010 33339817) Waist circumference adjusted for BMI (joint analysis main effects and physical activity interaction) ( 28448500) Waist circumference adjusted for BMI in active individuals ( 28448500) Waist circumference adjusted for body mass index ( 28448500 34021172) White blood cell count ( 32888494)
Interacting Genes		9 interacting genes: AP4M1 DSCR9 MED29 MED9 PLA2G2A RPS2 SNCA TLE3 UBC	23 interacting genes: APP BIRC5 BMP3 CHERP CSTF2 FBXO7 FEM1B FOXG1 H2AC1 H3C1 H4C1 HINFP KRTAP15-1 NDRG1 NOTCH1 PIN1 RPL4 SIX1 SIX3 SRP14 TAOK2 TCF4 USP47
Entrez ID		55031	7090
HPRD ID		11668	02558
Ensembl ID		ENSG00000170242	ENSG00000140332
Uniprot IDs		Q96K76	B3KUA2 H0YL70 Q04726 Q6PRX3
PDB IDs
Enriched GO Terms of Interacting Partners?		Mitochondrial Outer Membrane Response To Desipramine Negative Regulation Of Norepinephrine Uptake Phospholipase D Inhibitor Activity Positive Regulation Of SNARE Complex Assembly Negative Regulation Of Dopamine Uptake Involved In Synaptic Transmission Positive Regulation Of DNA-templated Transcription, Elongation Positive Regulation Of Transcription Initiation By RNA Polymerase II RNA Polymerase II Preinitiation Complex Assembly Positive Regulation Of Transcription Elongation By RNA Polymerase II Mediator Complex Core Mediator Complex Transcription Preinitiation Complex Assembly Positive Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Initiation By RNA Polymerase II Regulation Of Norepinephrine Uptake Negative Regulation Of Mitochondrial Electron Transport, NADH To Ubiquinone Positive Regulation Of Hydrogen Peroxide Catabolic Process Regulation Of DNA-templated Transcription Initiation Regulation Of Transcription Elongation By RNA Polymerase II Negative Regulation Of Serotonin Uptake Transporter Regulator Activity Negative Regulation Of Chaperone-mediated Autophagy Protein Localization To Basolateral Plasma Membrane Regulation Of DNA-templated Transcription Elongation Phospholipid Binding Negative Regulation Of Dopamine Metabolic Process Regulation Of Serotonin Uptake AP-4 Adaptor Complex Transcription Coregulator Activity Negative Regulation Of Thrombin-activated Receptor Signaling Pathway Negative Regulation Of Catecholamine Metabolic Process	Protein Heterodimerization Activity Regulation Of Neuron Differentiation Nucleus Regulation Of Cell Cycle Regulation Of Cell Cycle Phase Transition Axon Midline Choice Point Recognition Regulation Of Neuroblast Proliferation Regulation Of Cell Cycle Process Axon Choice Point Recognition Regulation Of Mitotic Cell Cycle Regulation Of Wnt Signaling Pathway Regulation Of Cardioblast Proliferation Establishment Of Protein Localization To Organelle Mitogen-activated Protein Kinase Kinase Binding Apoptotic Process Nucleoplasm Negative Regulation Of Neuron Differentiation Cell Death Programmed Cell Death Positive Regulation Of Transcription By RNA Polymerase II Protein Targeting Structural Constituent Of Chromatin Negative Regulation Of Cell Cycle Phase Transition Positive Regulation Of Neuron Differentiation Regulation Of Neural Precursor Cell Proliferation Regulation Of Cell Proliferation Involved In Heart Morphogenesis Regulation Of Canonical Wnt Signaling Pathway Cell Morphogenesis Involved In Neuron Differentiation Notch Signaling Pathway Prostate Gland Epithelium Morphogenesis Negative Regulation Of Cell Cycle Process Epithelial Cell Maturation Nucleosome Cellular Developmental Process Regulation Of Cell Differentiation Positive Regulation Of Neuroblast Proliferation Survivin Complex Negative Regulation Of DNA-templated Transcription Negative Regulation Of Cell Cycle Regulation Of Intracellular Signal Transduction Regulation Of Cell Population Proliferation Negative Regulation Of RNA Biosynthetic Process Amyloid-beta Complex Growth Cone Lamellipodium Positive Regulation Of RNA Biosynthetic Process DNA Binding Regulation Of Response To Calcium Ion Amylin Binding Cell Maturation Positive Regulation Of Toll Signaling Pathway
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