USP10 and ANLN

Number of citations of the paper that reports this interaction (PubMedID 36526897)
63

Data Source:
BioGRID (affinity chromatography technology, affinity chromatography technology, pull down)

		USP10	ANLN
Description		ubiquitin specific peptidase 10	anillin, actin binding protein
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytosolic Ribosome Protein-containing Complex Intermediate Filament Cytoskeleton	Nucleus Nucleoplasm Cytoplasm Actomyosin Contractile Ring Cytosol Cytoskeleton Cell Cortex Actin Cytoskeleton Midbody Bleb Cell Projection
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Transmembrane Transporter Binding Molecular Function Inhibitor Activity	Actin Binding Protein Binding Cadherin Binding
	Biological Process	DNA Repair Chromatin Remodeling Proteolysis Protein Monoubiquitination Autophagy DNA Damage Response Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Stress Granule Assembly Monoubiquitinated Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Stress Granule Assembly Cellular Response To Interleukin-1 Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Mitotic Cytokinesis Actomyosin Contractile Ring Assembly Septin Ring Assembly Hematopoietic Progenitor Cell Differentiation Regulation Of Exit From Mitosis Septin Ring Organization Cell Division Podocyte Cell Migration Positive Regulation Of Bleb Assembly
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)	Red cell distribution width ( 32888494) Systolic blood pressure ( 26969751)
Interacting Genes		32 interacting genes: AKT1 ANLN AR AXIN1 CCND3 CFTR CTNNB1 DAAM1 FSCN1 FZR1 G3BP1 G3BP2 H2AC20 HDAC6 HNRNPLL KLF4 LINC00460 MAP1LC3B MSH2 NOTCH1 PABPC1 PCGF5 RAD51 RUNX1 SCNN1A SCNN1G SMAD4 SNX3 SOX21-AS1 TRNAU1AP UBC ZBTB7A	8 interacting genes: CEBPA CRK FOXP1 FZR1 MARCHF10 SEPTIN7 SUMO2 USP10
Entrez ID		9100	54443
HPRD ID		07029	09799
Ensembl ID		ENSG00000103194	ENSG00000011426
Uniprot IDs		A0A7G6J4N4 Q14694	A8K5D9 Q9NQW6
PDB IDs		7XHF 8TH6	2Y7B 4XH3 4XOI
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Binding Positive Regulation Of Cellular Component Organization Enzyme Binding Response To Alcohol Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Cellular Response To Oxygen-containing Compound Cellular Response To Hormone Stimulus Response To Ketone Negative Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of RNA Metabolic Process In Utero Embryonic Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Proliferation Involved In Heart Morphogenesis Chordate Embryonic Development Positive Regulation Of Gene Expression Epithelial Cell Differentiation Regulation Of Extracellular Matrix Organization Negative Regulation Of Metabolic Process Response To Lipid Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Axis Specification Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Cell Cortex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Negative Regulation Of Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Organelle Assembly Positive Regulation Of Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Endocardial Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Beta-catenin Binding Response To Mineralocorticoid Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Protein-containing Complex	Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Regulation Of Ubiquitin-dependent Protein Catabolic Process Positive Regulation Of Proteolysis Response To Peptide Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Protein Modification By Small Protein Conjugation Post-translational Protein Modification RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Regulation Of Embryonic Cell Shape Regulation Of Protein Catabolic Process Cellular Response To Tumor Necrosis Factor Cellular Response To Cytokine Stimulus Regulation Of Proteolysis Response To Vitamin B2 C/EBP Complex Helper T Cell Diapedesis Protein Phosphorylated Amino Acid Binding Response To Cholecystokinin Negative Regulation Of Stress Granule Assembly DNA Biosynthetic Process Positive Regulation Of Interleukin-21 Production Kinase Binding Regulation Of Organelle Organization CHOP-C/EBP Complex Response To Tumor Necrosis Factor Cerebellar Neuron Development DNA Synthesis Involved In Mitotic DNA Replication Response To Cytokine Regulation Of Cell Shape Positive Regulation Of Catabolic Process White Fat Cell Proliferation Myeloid Leukocyte Differentiation Negative Regulation Of Hematopoietic Stem Cell Proliferation Rb-E2F Complex Signal Transduction In Response To DNA Damage Protein Ubiquitination Positive Regulation Of Hydrogen Peroxide-mediated Programmed Cell Death Thymidine Biosynthetic Process Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Cellular Component Organization Regulation Of Macrophage Colony-stimulating Factor Production Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Positive Regulation Of Ubiquitin Protein Ligase Activity Response To Phenylpropanoid Diapedesis
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