USP10 and SNX3

Number of citations of the paper that reports this interaction (PubMedID 18632802)
0

Data Source:
HPRD (two hybrid, in vitro, in vivo)

		USP10	SNX3
Description		ubiquitin specific peptidase 10	sorting nexin 3
Image
GO Annotations	Cellular Component	Nucleus Nucleoplasm Cytoplasm Endosome Early Endosome Cytosol Cytosolic Ribosome Protein-containing Complex Intermediate Filament Cytoskeleton	Cytoplasm Endosome Early Endosome Cytosol Endosome Membrane Clathrin-coated Vesicle Retromer Complex Cytoplasmic Vesicle Early Endosome Membrane Early Phagosome Phagocytic Vesicle Extracellular Exosome
	Molecular Function	P53 Binding RNA Binding Cysteine-type Endopeptidase Activity Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Transmembrane Transporter Binding Molecular Function Inhibitor Activity	Protein Binding Lipid Binding Phosphatidylinositol-5-phosphate Binding Protein Phosphatase Binding Phosphatidylinositol-3-phosphate Binding Phosphatidylinositol Binding Phosphatidylinositol-4-phosphate Binding Phosphatidylinositol-3,5-bisphosphate Binding Phosphatidylinositol Phosphate Binding Retromer Complex Binding
	Biological Process	DNA Repair Chromatin Remodeling Proteolysis Protein Monoubiquitination Autophagy DNA Damage Response Regulation Of Autophagy Protein Deubiquitination Translesion Synthesis DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Protein Stability Stress Granule Assembly Monoubiquitinated Protein Deubiquitination Negative Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Stress Granule Assembly Cellular Response To Interleukin-1 Rescue Of Stalled Ribosome Ribosome-associated Ubiquitin-dependent Protein Catabolic Process	Response To Bacterium Membrane Invagination Positive Regulation Of Neuron Projection Development Protein Transport Protein To Membrane Docking Regulation Of Wnt Signaling Pathway Endocytic Recycling Late Endosome To Golgi Transport Negative Regulation Of Protein Catabolic Process Host-mediated Suppression Of Symbiont Invasion Negative Regulation Of Phagocytosis Negative Regulation Of Protein Transport Intralumenal Vesicle Formation Negative Regulation Of Early Endosome To Late Endosome Transport
Pathways		Termination of translesion DNA synthesis Ub-specific processing proteases	WNT ligand biogenesis and trafficking Ub-specific processing proteases
Drugs			S,S-(2-Hydroxyethyl)Thiocysteine
Diseases
GWAS		Appendicular lean mass ( 33097823) Copper levels ( 26025379) Height ( 18391951) High light scatter reticulocyte count ( 27863252 32888494) High light scatter reticulocyte percentage of red cells ( 27863252 32888494) Immature fraction of reticulocytes ( 32888494) Plasma factor VII activating protease levels ( 30070759) Response to mTOR inhibitor (everolimus) ( 24009623) Reticulocyte count ( 27863252 32888494) Reticulocyte fraction of red cells ( 27863252 32888494)
Interacting Genes		32 interacting genes: AKT1 ANLN AR AXIN1 CCND3 CFTR CTNNB1 DAAM1 FSCN1 FZR1 G3BP1 G3BP2 H2AC20 HDAC6 HNRNPLL KLF4 LINC00460 MAP1LC3B MSH2 NOTCH1 PABPC1 PCGF5 RAD51 RUNX1 SCNN1A SCNN1G SMAD4 SNX3 SOX21-AS1 TRNAU1AP UBC ZBTB7A	10 interacting genes: ARL6IP1 BARD1 BRCA1 LIG4 PAXIP1 RPRM SCNN1A STX11 TSC22D2 USP10
Entrez ID		9100	8724
HPRD ID		07029	09333
Ensembl ID		ENSG00000103194	ENSG00000112335
Uniprot IDs		A0A7G6J4N4 Q14694	O60493
PDB IDs		7XHF 8TH6	2MXC 2YPS 5F0J 5F0L 5F0M 5F0P 7BLO
Enriched GO Terms of Interacting Partners?		Transcription Corepressor Binding Positive Regulation Of Cellular Component Organization Enzyme Binding Response To Alcohol Epithelial Cell Differentiation Involved In Prostate Gland Development Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Nucleobase-containing Compound Metabolic Process SMAD Binding Cellular Response To Oxygen-containing Compound Cellular Response To Hormone Stimulus Response To Ketone Negative Regulation Of Macromolecule Metabolic Process I-SMAD Binding Negative Regulation Of RNA Metabolic Process In Utero Embryonic Development Negative Regulation Of Canonical Wnt Signaling Pathway Regulation Of Cell Proliferation Involved In Heart Morphogenesis Chordate Embryonic Development Positive Regulation Of Gene Expression Epithelial Cell Differentiation Regulation Of Extracellular Matrix Organization Negative Regulation Of Metabolic Process Response To Lipid Embryo Development Ending In Birth Or Egg Hatching Multicellular Organism Development Positive Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Axis Specification Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Biosynthetic Process Cytosol Negative Regulation Of Wnt Signaling Pathway Positive Regulation Of Extracellular Matrix Organization Cell Cortex Positive Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Multicellular Organismal-level Water Homeostasis Sensory Perception Of Salty Taste Negative Regulation Of Biosynthetic Process Regulation Of Wnt Signaling Pathway Positive Regulation Of Organelle Assembly Positive Regulation Of Epithelial Cell Proliferation Regulation Of Mitotic Cell Cycle Endocardial Cell Differentiation Positive Regulation Of Cellular Component Biogenesis Beta-catenin Binding Response To Mineralocorticoid Regulation Of Cell Cycle Process Regulation Of Anaphase-promoting Complex-dependent Catabolic Process Regulation Of Protein Metabolic Process Regulation Of Cellular Component Organization Protein-containing Complex	Histone H2AK127 Ubiquitin Ligase Activity Histone H2AK129 Ubiquitin Ligase Activity BRCA1-BARD1 Complex Response To Ionizing Radiation BRCA1-B Complex Nuclear Ubiquitin Ligase Complex BRCA1-C Complex DNA Repair BRCA1-A Complex Ubiquitin-modified Histone Reader Activity Cellular Response To Ionizing Radiation DNA Recombination DNA Strand Resection Involved In Replication Fork Processing DNA Metabolic Process Regulation Of Cell Cycle G2/M Phase Transition DNA Damage Response Regulation Of DNA Damage Checkpoint Response To Radiation Signal Transduction In Response To DNA Damage Protein K6-linked Ubiquitination Cellular Response To Radiation Regulation Of Cell Cycle Condensed Chromosome Postreplication Repair Homologous Recombination DNA Damage Response, Signal Transduction By P53 Class Mediator Chromatin Remodeling Mitotic G2/M Transition Checkpoint Negative Regulation Of MRNA 3'-end Processing Establishment Of Integrated Proviral Latency Negative Regulation Of G2/M Transition Of Mitotic Cell Cycle P53 Binding Negative Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of Cell Cycle Chromatin Organization Negative Regulation Of Apoptotic Process Cellular Response To Stress Establishment Of Viral Latency Negative Regulation Of Stress Granule Assembly DNA Biosynthetic Process Negative Regulation Of Programmed Cell Death Signal Transduction By P53 Class Mediator Ubiquitin Ligase Complex Regulation Of Cell Cycle Phase Transition Regulation Of G2/M Transition Of Mitotic Cell Cycle DNA Ligase (ATP) Activity DNA Ligase IV Complex DNA Ligase Activity Chorion Development Pro-B Cell Differentiation
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