MCM8 and MCM7

Number of citations of the paper that reports this interaction (PubMedID 12771218)
35

Data Source:
HPRD (in vivo)

		MCM8	MCM7
Description		minichromosome maintenance 8 homologous recombination repair factor	minichromosome maintenance complex component 7
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome MCM Complex MCM8-MCM9 Complex	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Membrane MCM Complex CMG Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Damage Response Female Gamete Generation Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Mismatch Repair Involved In Maintenance Of Fidelity Involved In DNA-dependent DNA Replication Protein Localization To Chromatin	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Damage Response Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of DNA-templated DNA Replication Initiation Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex Orc1 removal from chromatin Activation of the pre-replicative complex	Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Estradiol levels ( 34255042) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)	Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)
Interacting Genes		4 interacting genes: FEM1C MCM4 MCM6 MCM7	80 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEBPA CEP68 CHEK1 COG6 CRLS1 CRYAA DBF4 DNAAF6 DUX4 DYNC1I1 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 LRR1 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RNF181 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM63 UBE3A UBQLN1 USHBP1
Entrez ID		84515	4176
HPRD ID		12186	01154
Ensembl ID		ENSG00000125885	ENSG00000166508
Uniprot IDs		B4DN82 Q9UJA3	A0A0S2Z4A5 C6EMX8 C9J8M6 P33993
PDB IDs		6L0O 7DP3 7WI7 7YOX 8S91 8S92 8S94	6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ
Enriched GO Terms of Interacting Partners?		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation DNA Helicase Activity Single-stranded DNA Binding Regulation Of DNA Replication Helicase Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication DNA Strand Elongation Involved In DNA Replication Chromosome, Telomeric Region Single-stranded DNA Helicase Activity DNA Strand Elongation Double-strand Break Repair DNA Recombination ATP Hydrolysis Activity Regulation Of DNA Metabolic Process DNA Repair Chromosome DNA Metabolic Process DNA Damage Response Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Mitotic DNA Replication Initiation Nuclear DNA Replication ATP Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Nucleoplasm Cellular Response To Stress Hydrolase Activity Nucleotide Binding Cul2-RING Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Macromolecule Metabolic Process DNA Binding Nucleobase-containing Compound Metabolic Process DNA-templated DNA Replication Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cellular Response To Xenobiotic Stimulus Response To Stress Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex	DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Replication Origin Recognition Complex Double-strand Break Repair Via Break-induced Replication Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle Process DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Cellular Response To Stress Recombinational Repair Mitotic DNA Integrity Checkpoint Signaling Chromosome Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle G1/S Phase Transition DNA Recombination Single-stranded DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Transcription Factor TFIIK Complex Mitotic G2/M Transition Checkpoint CAK-ERCC2 Complex Mitotic DNA Replication Initiation Regulation Of Lipid Kinase Activity Macromolecule Metabolic Process
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