MCM8

Description		minichromosome maintenance 8 homologous recombination repair factor
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome MCM Complex MCM8-MCM9 Complex
	Molecular Function	Nucleotide Binding DNA Binding Chromatin Binding Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity Enzyme Binding MutLbeta Complex Binding MutSalpha Complex Binding MutSbeta Complex Binding
	Biological Process	Double-strand Break Repair Via Homologous Recombination DNA Replication DNA Repair DNA Damage Response Female Gamete Generation Recombinational Interstrand Cross-link Repair Male Gamete Generation Protein Stabilization Mismatch Repair Involved In Maintenance Of Fidelity Involved In DNA-dependent DNA Replication Protein Localization To Chromatin
Pathways		E2F-enabled inhibition of pre-replication complex formation Activation of ATR in response to replication stress Unwinding of DNA CDC6 association with the ORC:origin complex Orc1 removal from chromatin Activation of the pre-replicative complex
Drugs
Diseases
GWAS		Breast cancer ( 29059683) Estradiol levels ( 34255042) HIV-1 viral setpoint ( 20205591) Menarche and menopause (age at onset) ( 19448621) Menopause (age at onset) ( 19448619 22267201 26414677 29773799) Preeclampsia ( 23551011) Uterine fibroids ( 30194396 31649266)
Novel Interacting Genes		4 novel interacting genes: FEM1C MCM4 MCM6 MCM7
Interacting Genes		4 interacting genes: FEM1C MCM4 MCM6 MCM7
Entrez ID		84515
HPRD ID		12186
Ensembl ID		ENSG00000125885
Uniprot IDs		B4DN82 Q9UJA3
PDB IDs		6L0O 7DP3 7WI7 7YOX 8S91 8S92 8S94
Enriched GO Terms of Interacting Partners?		CMG Complex Double-strand Break Repair Via Break-induced Replication MCM Complex Regulation Of DNA-templated DNA Replication Initiation DNA Replication Initiation DNA Helicase Activity Single-stranded DNA Binding Regulation Of DNA Replication Helicase Activity Double-strand Break Repair Via Homologous Recombination Recombinational Repair DNA Replication DNA Strand Elongation Involved In DNA Replication Chromosome, Telomeric Region Single-stranded DNA Helicase Activity DNA Strand Elongation Double-strand Break Repair DNA Recombination ATP Hydrolysis Activity Regulation Of DNA Metabolic Process DNA Repair Chromosome DNA Metabolic Process DNA Damage Response Single-stranded 3'-5' DNA Helicase Activity Mitotic DNA Replication Mitotic DNA Replication Initiation Nuclear DNA Replication ATP Binding Ubiquitin-dependent Protein Catabolic Process Via The C-end Degron Rule Pathway Nucleoplasm Cellular Response To Stress Hydrolase Activity Nucleotide Binding Cul2-RING Ubiquitin Ligase Complex Nucleic Acid Metabolic Process Macromolecule Metabolic Process DNA Binding Nucleobase-containing Compound Metabolic Process DNA-templated DNA Replication Cellular Response To Epidermal Growth Factor Stimulus Response To Epidermal Growth Factor Cellular Response To Xenobiotic Stimulus Response To Stress Ubiquitin-like Ligase-substrate Adaptor Activity Ubiquitin Ligase Complex
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