MCM7 and RBL2

Number of citations of the paper that reports this interaction (PubMedID 9566894)
89

Data Source:
HPRD (in vitro)

		MCM7	RBL2
Description		minichromosome maintenance complex component 7	RB transcriptional corepressor like 2
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Membrane MCM Complex CMG Complex	Chromatin Nucleus Nucleoplasm Transcription Regulator Complex Chromosome Nucleolus Cytosol Extracellular Exosome
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding DNA Binding Protein Binding Promoter-specific Chromatin Binding
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Damage Response Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of DNA-templated DNA Replication Initiation Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	Chromatin Organization Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Gene Expression Cell Differentiation Regulation Of Lipid Kinase Activity Regulation Of Cell Cycle Negative Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by DREAM complex Transcription of E2F targets under negative control by p107 (RBL1) and p130 (RBL2) in complex with HDAC1 G0 and Early G1 TP53 Regulates Transcription of Genes Involved in G2 Cell Cycle Arrest Cyclin E associated events during G1/S transition G1/S-Specific Transcription G1/S-Specific Transcription Cyclin D associated events in G1 Cyclin A:Cdk2-associated events at S phase entry FOXO-mediated transcription of cell cycle genes
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Appendicular lean mass ( 33097823) Body fat mass ( 28552196) Fasting insulin ( 34059833) General cognitive ability ( 29844566) Height ( 28552196) Hip circumference adjusted for BMI ( 34021172) Intelligence (MTAG) ( 29326435) Liver enzyme levels (alkaline phosphatase) ( 33972514) Metabolite levels ( 23823483) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		80 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEBPA CEP68 CHEK1 COG6 CRLS1 CRYAA DBF4 DNAAF6 DUX4 DYNC1I1 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 LRR1 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RNF181 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM63 UBE3A UBQLN1 USHBP1	46 interacting genes: BRCA1 BRF1 BRF2 BTG3 CCNA1 CCNA2 CCND1 CCND3 CCNE1 CDK2 CDK4 CDK6 CREG1 DCTN1 DGKZ E2F4 E2F5 EZH2 GRAMD4 HBP1 HDAC1 ID2 KMT5C LBX1 LDHC LIN52 MCM7 MNDA PCBD1 PHB1 PPP1R9B PPP2CA RAF1 RBBP8 RBBP9 RINT1 SKP2 SMARCA4 SNW1 SUV39H1 TAF1 TOP1 TP53BP1 UBTF USP4 XBP1
Entrez ID		4176	5934
HPRD ID		01154	01576
Ensembl ID		ENSG00000166508	ENSG00000103479
Uniprot IDs		A0A0S2Z4A5 C6EMX8 C9J8M6 P33993	Q08999
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	4XI9 5C1D
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Replication Origin Recognition Complex Double-strand Break Repair Via Break-induced Replication Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle Process DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Cellular Response To Stress Recombinational Repair Mitotic DNA Integrity Checkpoint Signaling Chromosome Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle G1/S Phase Transition DNA Recombination Single-stranded DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Transcription Factor TFIIK Complex Mitotic G2/M Transition Checkpoint CAK-ERCC2 Complex Mitotic DNA Replication Initiation Regulation Of Lipid Kinase Activity Macromolecule Metabolic Process	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle Phase Transition Regulation Of Cell Cycle Regulation Of Mitotic Cell Cycle Phase Transition Nucleoplasm Regulation Of Mitotic Cell Cycle Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Process Nucleus Cell Cycle Phase Transition Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Regulation Of RNA Metabolic Process Regulation Of Cell Cycle G1/S Phase Transition Regulation Of Gene Expression Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Regulation Of Primary Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Cellular Response To Stress Negative Regulation Of Cell Cycle Regulation Of Transcription By RNA Polymerase II Regulation Of Metabolic Process Regulation Of Cell Population Proliferation Transcription Corepressor Activity Negative Regulation Of Nucleobase-containing Compound Metabolic Process DNA Damage Response Regulation Of G2/M Transition Of Mitotic Cell Cycle Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Cyclin A2-CDK2 Complex Cell Division Regulation Of Cell Cycle G2/M Phase Transition Negative Regulation Of RNA Metabolic Process Negative Regulation Of Mitotic Cell Cycle Regulation Of Intracellular Steroid Hormone Receptor Signaling Pathway Negative Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Cell Cycle Phase Transition Response To Stress Transcription Regulator Complex DNA Damage Checkpoint Signaling Negative Regulation Of Mitotic Cell Cycle Phase Transition Nucleic Acid Metabolic Process Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Cycle Process Transcription Preinitiation Complex Assembly
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