MCM7 and INTS6

Number of citations of the paper that reports this interaction (PubMedID 17310990)
0

Data Source:
BioGRID (affinity chromatography technology, two hybrid)

		MCM7	INTS6
Description		minichromosome maintenance complex component 7	integrator complex subunit 6
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GO Annotations	Cellular Component	Chromosome, Telomeric Region Chromatin Nucleus Nucleoplasm Chromosome Nucleolus Membrane MCM Complex CMG Complex	Chromatin Nucleus Nucleoplasm Chromosome Actin Cytoskeleton Integrator Complex INTAC Complex
	Molecular Function	Nucleotide Binding DNA Binding DNA Helicase Activity Single-stranded DNA Binding Helicase Activity Protein Binding ATP Binding Hydrolase Activity ATP Hydrolysis Activity Single-stranded DNA Helicase Activity	Transmembrane Signaling Receptor Activity Protein Binding Protein-macromolecule Adaptor Activity
	Biological Process	Double-strand Break Repair Via Break-induced Replication DNA Replication DNA Replication Initiation DNA Strand Elongation Involved In DNA Replication DNA Damage Response Cell Population Proliferation Response To Xenobiotic Stimulus Regulation Of DNA-templated DNA Replication Initiation Regulation Of Phosphorylation Cellular Response To Epidermal Growth Factor Stimulus Cellular Response To Xenobiotic Stimulus	Transcription By RNA Polymerase II Transcription Elongation By RNA Polymerase II SnRNA Processing Regulation Of Transcription Elongation By RNA Polymerase II SnRNA 3'-end Processing Protein Localization To Chromatin RNA Polymerase II Transcription Initiation Surveillance
Pathways		Activation of ATR in response to replication stress Unwinding of DNA Assembly of the pre-replicative complex Assembly of the pre-replicative complex Orc1 removal from chromatin Activation of the pre-replicative complex Switching of origins to a post-replicative state	RNA polymerase II transcribes snRNA genes RNA polymerase II transcribes snRNA genes
Drugs
Diseases
GWAS		Brain morphology (MOSTest) ( 32665545) Refractive error ( 32231278) Subcortical volume (MOSTest) ( 32665545)	Amyotrophic lateral sclerosis (sporadic) ( 24529757)
Interacting Genes		80 interacting genes: ABI2 AK8 APP ASB8 C8orf34 CCDC102B CCND1 CCNH CDC42 CDC45 CDC6 CDC7 CDK7 CDKN1B CEBPA CEP68 CHEK1 COG6 CRLS1 CRYAA DBF4 DNAAF6 DUX4 DYNC1I1 ELOC ESCO2 FHL2 GOLGA2 H3-4 HIF1A IKBKG IKZF3 INTS6 KIFC3 LINC01554 LNX2 LRR1 MAGEA6 MBIP MCM10 MCM2 MCM3 MCM4 MCM5 MCM6 MCM8 MEOX2 MIPOL1 MNAT1 NAB2 NFKBIA ORC1 ORC2 ORC3 ORC4 ORC5 ORC6 PLK1 PNMA1 RAD17 RB1 RBL1 RBL2 RBM8A RBPMS RINT1 RNF181 RPA1 SMC1A SNTA1 SP2 SSX2IP TFIP11 TREX1 TRIM27 TRIM54 TRIM63 UBE3A UBQLN1 USHBP1	2 interacting genes: CTDP1 MCM7
Entrez ID		4176	26512
HPRD ID		01154	05063
Ensembl ID		ENSG00000166508	ENSG00000102786
Uniprot IDs		A0A0S2Z4A5 C6EMX8 C9J8M6 P33993	B3KU90 Q9UL03
PDB IDs		6XTX 6XTY 7PFO 7PLO 7W1Y 7W68 8B9D 8RWV 8S09 8S0A 8S0B 8S0D 8S0E 8S0F 8W0E 8W0F 8W0G 8W0I 9CAQ	7BV7 7CUN 7PKS 7YCX 8RBX 8RBZ 8RC4 8YJB
Enriched GO Terms of Interacting Partners?		DNA Replication Initiation DNA Replication DNA Replication Origin Binding DNA Metabolic Process Nuclear Origin Of Replication Recognition Complex Chromosome, Telomeric Region Nucleoplasm Regulation Of DNA Replication Origin Recognition Complex Double-strand Break Repair Via Break-induced Replication Nucleus DNA Damage Response Regulation Of Cell Cycle Phase Transition Regulation Of Mitotic Cell Cycle Phase Transition CMG Complex MCM Complex Regulation Of Mitotic Cell Cycle Regulation Of Nucleobase-containing Compound Metabolic Process Nucleic Acid Metabolic Process Negative Regulation Of Cell Cycle Single-stranded DNA Binding Regulation Of Cell Cycle Process DNA Repair Negative Regulation Of Mitotic Cell Cycle Negative Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Cell Cycle Negative Regulation Of Cell Cycle Process Negative Regulation Of Cell Cycle Phase Transition Double-strand Break Repair Via Homologous Recombination Regulation Of DNA Metabolic Process Cellular Response To Stress Recombinational Repair Mitotic DNA Integrity Checkpoint Signaling Chromosome Nucleobase-containing Compound Metabolic Process Regulation Of G1/S Transition Of Mitotic Cell Cycle Double-strand Break Repair Regulation Of DNA-templated DNA Replication Initiation Regulation Of Cell Cycle G1/S Phase Transition DNA Recombination Single-stranded DNA Helicase Activity Regulation Of Primary Metabolic Process Regulation Of G2/M Transition Of Mitotic Cell Cycle Regulation Of Cell Cycle G2/M Phase Transition Transcription Factor TFIIK Complex Mitotic G2/M Transition Checkpoint CAK-ERCC2 Complex Mitotic DNA Replication Initiation Regulation Of Lipid Kinase Activity Macromolecule Metabolic Process	CMG Complex Double-strand Break Repair Via Break-induced Replication DNA Strand Elongation Involved In DNA Replication Single-stranded DNA Helicase Activity Regulation Of DNA-templated DNA Replication Initiation DNA Strand Elongation MCM Complex Tat Protein Binding TFIIF-class Transcription Factor Complex Binding Host-mediated Activation Of Viral Transcription Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Negative Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development RNA Polymerase II CTD Heptapeptide Repeat Phosphatase Activity Exit From Mitosis DNA Replication Initiation Negative Regulation Of Cardiac Muscle Tissue Growth Spindle Midzone Host-mediated Perturbation Of Viral Transcription DNA Helicase Activity Negative Regulation Of Striated Muscle Cell Differentiation Negative Regulation Of Muscle Hypertrophy Host-mediated Activation Of Viral Process Negative Regulation Of Organ Growth Negative Regulation Of Cardiac Muscle Hypertrophy Cellular Response To Epidermal Growth Factor Stimulus Transcription Elongation By RNA Polymerase II Response To Epidermal Growth Factor DNA-templated Transcription Elongation Hydrolase Activity Cellular Response To Xenobiotic Stimulus Regulation Of Heart Growth Host-mediated Perturbation Of Viral Process Negative Regulation Of Muscle Cell Differentiation Regulation Of Cardiac Muscle Hypertrophy Protein Dephosphorylation Protein Serine/threonine Phosphatase Activity Regulation Of Striated Muscle Cell Differentiation Regulation Of Organ Growth Negative Regulation Of Developmental Growth Single-stranded DNA Binding Host-mediated Perturbation Of Symbiont Process Regulation Of DNA Replication Nucleic Acid Metabolic Process Modulation Of Process Of Another Organism Helicase Activity Dephosphorylation Double-strand Break Repair Via Homologous Recombination Phosphoprotein Phosphatase Activity Recombinational Repair DNA Replication
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