BAP1 and CASP8

Number of citations of the paper that reports this interaction (PubMedID 25640309)
0

Data Source:
BioGRID (two hybrid)

		BAP1	CASP8
Description		BRCA1 associated deubiquitinase 1	caspase 8
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol PR-DUB Complex	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Plasma Membrane Lamellipodium Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Projection Cell Body Ripoptosome
	Molecular Function	Chromatin Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Chromatin DNA Binding Histone H2A Deubiquitinase Activity	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Scaffold Protein Binding
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth In Utero Embryonic Development Tissue Homeostasis Thrombocyte Differentiation Chromatin Organization Proteolysis Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation Erythrocyte Differentiation Neutrophil Differentiation Granulocyte Differentiation Heterochromatin Formation Myeloid Cell Apoptotic Process Monoubiquitinated Protein Deubiquitination Common Myeloid Progenitor Cell Proliferation Protein Modification Process Platelet Morphogenesis Erythrocyte Maturation Nucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Regulation Of Cell Cycle Hematopoietic Stem Cell Homeostasis Macrophage Homeostasis Neuron Cellular Homeostasis Leukocyte Proliferation Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Autophagosome Assembly Angiogenesis Regulation Of Cytokine Production Regulation Of Immune System Process Proteolysis Apoptotic Process Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Processing Natural Killer Cell Activation Cell Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Response To Tumor Necrosis Factor TRAIL-activated Apoptotic Signaling Pathway T Cell Activation B Cell Activation Regulation Of Apoptotic Process Chordate Embryonic Development Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Regulation Of Innate Immune Response Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Animal Organ Development Proteolysis Involved In Protein Catabolic Process Protein Maturation Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Pyroptotic Inflammatory Response Cellular Response To Mechanical Stimulus Response To Anesthetic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Self Proteolysis Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Microbial modulation of RIPK1-mediated regulated necrosis Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling
Drugs			Trichostatin A AN-9 Bryostatin 1 Bardoxolone Oleandrin
Diseases			Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	Basal cell carcinoma ( 33549134 25855136 28177523) Breast cancer ( 29059683) Chronic lymphocytic leukemia ( 23770605 26956414 28165464) Cutaneous malignant melanoma ( 32341527) Esophageal squamous cell carcinoma ( 25129146) Lymphocyte count ( 27863252) Melanoma ( 28212542 21983787) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-small cell lung cancer ( 31326317) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Rheumatoid arthritis ( 30423114 24390342) Spleen volume ( 34128465) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: ASXL1 BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 H2BC3 HIF1A IGF1R ITPR3 LINC00598 MAP3K1 NBN PARP3 PLN PTPRJ RB1CC1 STK11 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	139 interacting genes: AGR3 ANGPTL4 AP1M1 APAF1 APP AR ATAD2 ATG4D ATP1A3 BAP1 BCAP31 BCL2 BCL2L1 BCL2L10 BEX1 BFAR BID BIRC6 BLID BMPR2 BRD1 CASC3 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CCNL1 CDH1 CDH13 CDK11B CDKN1B CFLAR CHD3 CHUK CNBP COPS6 CRADD CTNNB1 DDX5 DEDD DEDD2 EDA2R EIF2AK2 EPSTI1 ERBB4 ERRFI1 FADD FAF1 FAS FYN GLCE GMEB1 GREB1 GRIA1 GZMB HBP1 HDAC7 HECTD3 HIP1 IFT57 IKBKB IKBKG IL13RA2 IL24 ILK KLK5 KLK9 KRT18 LYPD3 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 NSD3 OGT PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PIK3C3 PLA2G4B PLEC PLIN4 PRDM14 PRDX6 PRKCI PRKCZ PRKN PRRX2 PRSS50 PSEN1 PSEN2 PSMC3IP QDPR RALBP1 RB1 RIPK1 RIPK2 RNF31 RYBP S100A14 SCGB2A2 SERPINB5 SNRPD3 SNX19 SOX2 SRC SRF ST14 STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 UBC UMPS USO1 VIM VPS45 YBX1 ZNF707
Entrez ID		8314	841
HPRD ID		04366	03459
Ensembl ID		ENSG00000163930	ENSG00000064012
Uniprot IDs		F8W6N3 Q92560	A0A8Q3SID9 Q14790
PDB IDs		7VPW 8H1T 8SVF	1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7 4PRZ 4PS1 4ZBW 5H31 5H33 5JQE 5L08 6AGW 6PX9 7DEE 7LVJ 7LVM 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Modification Process Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Nucleus Protein Metabolic Process Telomere Maintenance Via Telomere Trimming Nuclear Body Cysteine-type Peptidase Activity Heterochromatin Formation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleoplasm Epigenetic Regulation Of Gene Expression Macromolecule Metabolic Process Response To Radiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Apoptotic Signaling Pathway Response To Light Stimulus Chromosome Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Deubiquitination Regulation Of Cell Communication Regulation Of Signaling Telomere Maintenance Negative Regulation Of Metabolic Process BRCA1-C Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Localization To Chromosome Negative Regulation Of Growth Double-strand Break Repair Protein Modification By Small Protein Removal Nucleosome DNA Damage Response Telomere Organization Ubiquitin-modified Histone Reader Activity Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction	Programmed Cell Death Cell Death Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Extrinsic Apoptotic Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Stress Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Cytosol Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Signaling Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Cytoplasm Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Oxygen-containing Compound Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Cysteine-type Endopeptidase Activity Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Programmed Necrotic Cell Death
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