BAP1 and UBE2O

Number of citations of the paper that reports this interaction (PubMedID 35446349)
52

Data Source:
BioGRID (enzymatic study, affinity chromatography technology)

		BAP1	UBE2O
Description		BRCA1 associated deubiquitinase 1	ubiquitin conjugating enzyme E2 O
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GO Annotations	Cellular Component	Nucleus Nucleoplasm Chromosome Cytoplasm Cytosol PR-DUB Complex	Nucleus Nucleoplasm Cytoplasm Cytosol Nuclear Body
	Molecular Function	Chromatin Binding Cysteine-type Deubiquitinase Activity Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Chromatin DNA Binding Histone H2A Deubiquitinase Activity	Nucleotide Binding RNA Binding Ubiquitin-protein Transferase Activity Protein Binding ATP Binding Transferase Activity Ubiquitin Protein Ligase Activity Ubiquitin Conjugating Enzyme Activity
	Biological Process	Mitotic Cell Cycle Regulation Of Cell Growth In Utero Embryonic Development Tissue Homeostasis Thrombocyte Differentiation Chromatin Organization Proteolysis Ubiquitin-dependent Protein Catabolic Process Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Gene Expression Regulation Of Gene Expression Protein Deubiquitination Cell Differentiation Erythrocyte Differentiation Neutrophil Differentiation Granulocyte Differentiation Heterochromatin Formation Myeloid Cell Apoptotic Process Monoubiquitinated Protein Deubiquitination Common Myeloid Progenitor Cell Proliferation Protein Modification Process Platelet Morphogenesis Erythrocyte Maturation Nucleate Erythrocyte Differentiation Negative Regulation Of DNA-templated Transcription Regulation Of Inflammatory Response Regulation Of Cell Cycle Hematopoietic Stem Cell Homeostasis Macrophage Homeostasis Neuron Cellular Homeostasis Leukocyte Proliferation Protein K48-linked Deubiquitination Regulation Of Cytokine Production Involved In Inflammatory Response Positive Regulation Of Protein Targeting To Mitochondrion	Protein Monoubiquitination Protein Ubiquitination Positive Regulation Of BMP Signaling Pathway Retrograde Transport, Endosome To Golgi Protein K63-linked Ubiquitination
Pathways		UCH proteinases Recruitment and ATM-mediated phosphorylation of repair and signaling proteins at DNA double strand breaks	Antigen processing: Ubiquitination & Proteasome degradation
Drugs
Diseases
GWAS		Autism spectrum disorder or schizophrenia ( 28540026) Bipolar disorder ( 21926972) Parkinson's disease ( 28892059) Schizophrenia ( 23974872)	High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 27863252) Lymphocyte percentage of white cells ( 27863252 32888494) Mitochondrial DNA levels ( 25240745) Neutrophil percentage of white cells ( 32888494) Platelet distribution width ( 32888494) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) White blood cell count ( 32888494)
Interacting Genes		32 interacting genes: ASXL1 BAG4 BCAR3 BRCA1 CASP8 CBLC CBX5 ESR1 H2AC18 H2AC20 H2AC4 H2BC3 HIF1A IGF1R ITPR3 LINC00598 MAP3K1 NBN PARP3 PLN PTPRJ RB1CC1 STK11 TRIM63 UBC UBE2O USP15 USP2 USP21 USP28 XRCC3 YY1	23 interacting genes: APPL1 BAP1 CAVIN1 CPNE1 CPNE2 CPNE4 GRIK1 HEXIM1 HUNK IFRD2 ITCH MAF MDM2 MXI1 PDK1 PRKN RNF10 RNF31 SHBG TRIM27 UBA6 UBC UBE2D3
Entrez ID		8314	63893
HPRD ID		04366	10928
Ensembl ID		ENSG00000163930	ENSG00000175931
Uniprot IDs		F8W6N3 Q92560	Q9C0C9
PDB IDs		7VPW 8H1T 8SVF	7UN3 7UN6
Enriched GO Terms of Interacting Partners?		Chromatin Remodeling Chromatin Organization Protein Modification Process Post-translational Protein Modification Regulation Of Intracellular Signal Transduction Nucleus Protein Metabolic Process Telomere Maintenance Via Telomere Trimming Nuclear Body Cysteine-type Peptidase Activity Heterochromatin Formation Negative Regulation Of Intracellular Signal Transduction Positive Regulation Of Cell Communication Positive Regulation Of Signaling Nucleoplasm Epigenetic Regulation Of Gene Expression Macromolecule Metabolic Process Response To Radiation Negative Regulation Of Gene Expression, Epigenetic Positive Regulation Of Signal Transduction Ubiquitin Protein Ligase Binding Negative Regulation Of MiRNA Transcription Structural Constituent Of Chromatin Cysteine-type Deubiquitinase Activity Apoptotic Signaling Pathway Response To Light Stimulus Chromosome Negative Regulation Of Signal Transduction Regulation Of Signal Transduction Protein Deubiquitination Regulation Of Cell Communication Regulation Of Signaling Telomere Maintenance Negative Regulation Of Metabolic Process BRCA1-C Complex Negative Regulation Of Cell Communication Negative Regulation Of Signaling Protein Localization To Chromosome Negative Regulation Of Growth Double-strand Break Repair Protein Modification By Small Protein Removal Nucleosome DNA Damage Response Telomere Organization Ubiquitin-modified Histone Reader Activity Double-strand Break Repair Via Homologous Recombination Positive Regulation Of DNA Repair Recombinational Repair Negative Regulation Of Gene Expression Positive Regulation Of Intracellular Signal Transduction	Protein Ubiquitination Post-translational Protein Modification Protein Autoubiquitination Protein Modification By Small Protein Conjugation Ubiquitin Protein Ligase Activity Regulation Of Protein Targeting To Mitochondrion Modification-dependent Protein Catabolic Process Ubiquitin-protein Transferase Activity Protein Monoubiquitination Protein Polyubiquitination Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Regulation Of Necroptotic Process Proteolysis Positive Regulation Of Protein Targeting To Mitochondrion Regulation Of Programmed Necrotic Cell Death Positive Regulation Of Establishment Of Protein Localization To Mitochondrion Protein Modification Process Macromolecule Catabolic Process Calcium-dependent Phospholipid Binding Negative Regulation Of Macromolecule Biosynthetic Process Positive Regulation Of Establishment Of Protein Localization Negative Regulation Of Biosynthetic Process Response To Metal Ion Cellular Response To Metal Ion Protein K29-linked Ubiquitination Protein K63-linked Ubiquitination Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Cellular Response To Calcium Ion Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of Macromolecule Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Negative Regulation Of Viral Transcription Transferase Activity Identical Protein Binding Negative Regulation Of RNA Metabolic Process SUMO Transferase Activity Intracellular Vesicle Regulation Of Viral Transcription Ubiquitin Binding Negative Regulation Of Metabolic Process Nucleus Response To Ether Proteasomal Protein Catabolic Process Protein K48-linked Ubiquitination Negative Regulation Of Intrinsic Apoptotic Signaling Pathway By P53 Class Mediator Negative Regulation Of Gene Expression Endosome Membrane
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