CASP8 and CDKN1B

Number of citations of the paper that reports this interaction (PubMedID 28319113)
39

Data Source:
BioGRID (genetic interference)
HPRD (in vitro)

		CASP8	CDKN1B
Description		caspase 8	cyclin dependent kinase inhibitor 1B
Image
GO Annotations	Cellular Component	Nucleus Cytoplasm Mitochondrion Mitochondrial Outer Membrane Cytosol Cytoskeleton Plasma Membrane Lamellipodium Death-inducing Signaling Complex CD95 Death-inducing Signaling Complex Protein-containing Complex Cell Projection Cell Body Ripoptosome	Nucleus Nucleoplasm Cytoplasm Endosome Centrosome Cytosol Cilium Cul4A-RING E3 Ubiquitin Ligase Complex Ciliary Basal Body
	Molecular Function	Cysteine-type Endopeptidase Activity Death Receptor Binding Tumor Necrosis Factor Receptor Binding Protein Binding Peptidase Activity Cysteine-type Peptidase Activity Hydrolase Activity Ubiquitin Protein Ligase Binding Death Effector Domain Binding Identical Protein Binding Protein-containing Complex Binding Scaffold Protein Binding	Protein Kinase Inhibitor Activity Cyclin-dependent Protein Serine/threonine Kinase Inhibitor Activity Protein Binding Protein Kinase Binding Protein Phosphatase Binding Cyclin-dependent Protein Kinase Regulator Activity Cyclin Binding Ubiquitin Protein Ligase Binding Protein-containing Complex Binding Protein-folding Chaperone Binding Molecular Adaptor Activity Molecular Function Inhibitor Activity Ubiquitin Ligase Activator Activity
	Biological Process	Autophagosome Assembly Angiogenesis Regulation Of Cytokine Production Regulation Of Immune System Process Proteolysis Apoptotic Process Heart Development Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Positive Regulation Of Signal Transduction Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Protein Processing Natural Killer Cell Activation Cell Differentiation Macrophage Differentiation Positive Regulation Of Cell Migration Response To Cobalt Ion Response To Estradiol Response To Lipopolysaccharide Positive Regulation Of Interleukin-1 Beta Production Response To Tumor Necrosis Factor TRAIL-activated Apoptotic Signaling Pathway T Cell Activation B Cell Activation Regulation Of Apoptotic Process Chordate Embryonic Development Positive Regulation Of Apoptotic Process Positive Regulation Of Canonical NF-kappaB Signal Transduction Negative Regulation Of Canonical NF-kappaB Signal Transduction Positive Regulation Of Neuron Apoptotic Process Regulation Of Innate Immune Response Response To Ethanol Positive Regulation Of Macrophage Differentiation Positive Regulation Of Proteolysis Animal Organ Development Proteolysis Involved In Protein Catabolic Process Protein Maturation Negative Regulation Of Necroptotic Process Syncytiotrophoblast Cell Differentiation Involved In Labyrinthine Layer Development Pyroptotic Inflammatory Response Cellular Response To Mechanical Stimulus Response To Anesthetic Apoptotic Signaling Pathway Extrinsic Apoptotic Signaling Pathway Execution Phase Of Apoptosis Self Proteolysis Positive Regulation Of Pyroptotic Inflammatory Response Positive Regulation Of Execution Phase Of Apoptosis	Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity G1/S Transition Of Mitotic Cell Cycle Placenta Development Potassium Ion Transport Apoptotic Process Regulation Of Exit From Mitosis Notch Signaling Pathway Regulation Of Mitotic Cell Cycle Heart Development Sensory Perception Of Sound Positive Regulation Of Cell Population Proliferation Negative Regulation Of Cell Population Proliferation Programmed Cell Death Negative Regulation Of Cell Growth DNA Damage Response, Signal Transduction By P53 Class Mediator Regulation Of Cell Migration Positive Regulation Of Microtubule Polymerization Negative Regulation Of Kinase Activity Positive Regulation Of Protein Catabolic Process Negative Regulation Of Cyclin-dependent Protein Serine/threonine Kinase Activity Positive Regulation Of DNA Replication Negative Regulation Of DNA-templated Transcription Negative Regulation Of Growth Negative Regulation Of Mitotic Cell Cycle Autophagic Cell Death Inner Ear Development Negative Regulation Of Epithelial Cell Proliferation Nuclear Export Regulation Of Cell Cycle Epithelial Cell Proliferation Involved In Prostate Gland Development Negative Regulation Of Epithelial Cell Proliferation Involved In Prostate Gland Development Cellular Response To Antibiotic Cellular Response To Lithium Ion Cellular Senescence Regulation Of Mitotic Cell Cycle Phase Transition Regulation Of Lens Fiber Cell Differentiation Regulation Of Cell Cycle G1/S Phase Transition Epithelial Cell Apoptotic Process Negative Regulation Of Cyclin-dependent Protein Kinase Activity Negative Regulation Of Epithelial Cell Apoptotic Process Negative Regulation Of Vascular Associated Smooth Muscle Cell Proliferation Negative Regulation Of Cardiac Muscle Tissue Regeneration Regulation Of G1/S Transition Of Mitotic Cell Cycle
Pathways		Apoptotic cleavage of cellular proteins Caspase activation via Death Receptors in the presence of ligand NOD1/2 Signaling Pathway TRIF-mediated programmed cell death Caspase-mediated cleavage of cytoskeletal proteins Regulation by c-FLIP RIPK1-mediated regulated necrosis CASP8 activity is inhibited TNFR1-induced proapoptotic signaling Regulation of TNFR1 signaling CLEC7A/inflammasome pathway Regulation of necroptotic cell death Dimerization of procaspase-8 Activation, myristolyation of BID and translocation to mitochondria Apoptotic execution phase FasL/ CD95L signaling TRAIL signaling TLR3-mediated TICAM1-dependent programmed cell death NF-kB activation through FADD/RIP-1 pathway mediated by caspase-8 and -10 Microbial modulation of RIPK1-mediated regulated necrosis Defective RIPK1-mediated regulated necrosis Regulation of NF-kappa B signaling	SCF(Skp2)-mediated degradation of p27/p21 AKT phosphorylates targets in the cytosol Senescence-Associated Secretory Phenotype (SASP) DNA Damage/Telomere Stress Induced Senescence RHO GTPases activate CIT Constitutive Signaling by AKT1 E17K in Cancer TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Cyclin E associated events during G1/S transition Cyclin D associated events in G1 p53-Dependent G1 DNA Damage Response Cyclin A:Cdk2-associated events at S phase entry PTK6 Regulates Cell Cycle FLT3 Signaling FOXO-mediated transcription of cell cycle genes Estrogen-dependent nuclear events downstream of ESR-membrane signaling Defective binding of RB1 mutants to E2F1,(E2F2, E2F3)
Drugs		Trichostatin A AN-9 Bryostatin 1 Bardoxolone Oleandrin
Diseases		Autoimmune lymphoproliferative syndromes (ALPS), including the following five diseases: CD95 (Fas) defect, ALPS type 1a; CD95L (Fas ligand) defect, ALPS type 1b; Caspase 10 defect, ALPS type 2a; Caspase 8 defext, ALPS type 2b; Activaing N-Ras defect, N-Ras ALPS	Prostate cancer
GWAS		Basal cell carcinoma ( 33549134 25855136 28177523) Breast cancer ( 29059683) Chronic lymphocytic leukemia ( 23770605 26956414 28165464) Cutaneous malignant melanoma ( 32341527) Esophageal squamous cell carcinoma ( 25129146) Lymphocyte count ( 27863252) Melanoma ( 28212542 21983787) Multiple sclerosis ( 31604244) Neutrophil percentage of white cells ( 32888494) Nevus count or cutaneous melanoma ( 30429480 32341527) Non-small cell lung cancer ( 31326317) Plateletcrit ( 32888494) Prostate cancer ( 29892016) Rheumatoid arthritis ( 30423114 24390342) Spleen volume ( 34128465) White blood cell count ( 32888494)	Appendicular lean mass ( 33097823) Brain morphology (MOSTest) ( 32665545) Diastolic blood pressure ( 30487518) Mean arterial pressure ( 29403010 30487518) Metabolite levels ( 23823483) Monocyte percentage of white cells ( 32888494) Mosaic loss of chromosome Y (Y chromosome dosage) ( 31624269) Plateletcrit ( 32888494) Prostate cancer ( 29892016 31562322) Refractive error ( 32231278) Systemic lupus erythematosus ( 23273568 33272962) Systolic blood pressure ( 30487518) Type 2 diabetes ( 30297969)
Interacting Genes		139 interacting genes: AGR3 ANGPTL4 AP1M1 APAF1 APP AR ATAD2 ATG4D ATP1A3 BAP1 BCAP31 BCL2 BCL2L1 BCL2L10 BEX1 BFAR BID BIRC6 BLID BMPR2 BRD1 CASC3 CASP1 CASP10 CASP14 CASP2 CASP3 CASP4 CASP6 CASP7 CASP8AP2 CASP9 CCNL1 CDH1 CDH13 CDK11B CDKN1B CFLAR CHD3 CHUK CNBP COPS6 CRADD CTNNB1 DDX5 DEDD DEDD2 EDA2R EIF2AK2 EPSTI1 ERBB4 ERRFI1 FADD FAF1 FAS FYN GLCE GMEB1 GREB1 GRIA1 GZMB HBP1 HDAC7 HECTD3 HIP1 IFT57 IKBKB IKBKG IL13RA2 IL24 ILK KLK5 KLK9 KRT18 LYPD3 MAP1LC3B MAP3K14 MAP4K4 MAPK1 MAPK3 MAPT NOD1 NOL3 NR1H4 NSD3 OGT PARK7 PARP1 PARP2 PCYT1A PDIA6 PEA15 PIAS1 PICALM PIK3C3 PLA2G4B PLEC PLIN4 PRDM14 PRDX6 PRKCI PRKCZ PRKN PRRX2 PRSS50 PSEN1 PSEN2 PSMC3IP QDPR RALBP1 RB1 RIPK1 RIPK2 RNF31 RYBP S100A14 SCGB2A2 SERPINB5 SNRPD3 SNX19 SOX2 SRC SRF ST14 STK24 SUMO1 TFCP2 TNFRSF10A TNFRSF10B TOPORS TRAF1 TRAF2 UBC UMPS USO1 VIM VPS45 YBX1 ZNF707	70 interacting genes: ABL1 AKT1 ARHGDIA ARIH1 CAMK1 CASP8 CCNA1 CCNA2 CCNB1 CCND1 CCND2 CCND3 CCNE2 CDC34 CDK2 CDK3 CDK4 CDK5 CKS1B COP1 COPS5 CUL4A DCLRE1C GRB2 H1-1 H1-5 IRF1 KAT2B KPNA1 KPNA3 KPNA4 KPNA5 KPNA6 LYN MAPK10 MCM7 MTUS2 MYC NUP50 PIN1 PSMB1 RCHY1 RNF123 RNF6 RPS6KA1 SGK1 SIRT6 SKP1 SKP2 SPDYA SRC STMN1 TRAF2 TSC2 UBAC1 UBB UBE2B UBE2D2 UBE2L3 UBE3A UCHL1 WWP1 XPO1 YES1 YWHAB YWHAE YWHAG YWHAH YWHAQ YWHAZ
Entrez ID		841	1027
HPRD ID		03459	02867
Ensembl ID		ENSG00000064012	ENSG00000111276
Uniprot IDs		A0A8Q3SID9 Q14790	P46527 Q6I9V6
PDB IDs		1F9E 1I4E 1QDU 1QTN 2C2Z 2FUN 2K7Z 2Y1L 3H11 3KJN 3KJQ 4JJ7 4PRZ 4PS1 4ZBW 5H31 5H33 5JQE 5L08 6AGW 6PX9 7DEE 7LVJ 7LVM 8YBX 8YD7 8YD8 8YM4 8YM5 8YM6 8YNI 8YNK 8YNL 8YNM 8YNN	1H27 1JSU 2AST 5UQ3 6ATH 6P8E 6P8F 6P8G 7B5L 7B5M 7B5R 7OR8 7ORG 7ORH 7ORS 7ORT 8BYA 8BYL 8BZO
Enriched GO Terms of Interacting Partners?		Programmed Cell Death Cell Death Apoptotic Process Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Apoptotic Signaling Pathway Positive Regulation Of Programmed Cell Death Positive Regulation Of Apoptotic Process Intracellular Signal Transduction Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Signal Transduction Positive Regulation Of Signaling Cell Surface Receptor Signaling Pathway Positive Regulation Of Cell Communication Extrinsic Apoptotic Signaling Pathway Signal Transduction Negative Regulation Of Programmed Cell Death Cellular Response To Stress Response To Stress Regulation Of Extrinsic Apoptotic Signaling Pathway Negative Regulation Of Apoptotic Process Cytosol Regulation Of Signal Transduction Regulation Of Intracellular Signal Transduction Positive Regulation Of Intracellular Signal Transduction Regulation Of Neuron Apoptotic Process Extrinsic Apoptotic Signaling Pathway Via Death Domain Receptors Regulation Of Signaling Regulation Of Cell Communication Regulation Of Canonical NF-kappaB Signal Transduction Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Primary Metabolic Process Regulation Of RNA Metabolic Process Positive Regulation Of Neuron Apoptotic Process Cytoplasm Positive Regulation Of Canonical NF-kappaB Signal Transduction Cellular Response To Oxygen-containing Compound Ubiquitin Protein Ligase Binding Intrinsic Apoptotic Signaling Pathway Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Protein Metabolic Process Regulation Of Macromolecule Metabolic Process Cysteine-type Endopeptidase Activity Protein Metabolic Process Regulation Of Metabolic Process Negative Regulation Of Apoptotic Signaling Pathway Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Regulation Of Programmed Necrotic Cell Death	Cell Cycle G1/S Phase Transition G1/S Transition Of Mitotic Cell Cycle Protein Modification Process Nucleus Cell Cycle Phase Transition Nucleoplasm Modification-dependent Protein Catabolic Process Mitotic Cell Cycle Phase Transition Cytosol Post-translational Protein Modification Proteolysis Involved In Protein Catabolic Process Ubiquitin-dependent Protein Catabolic Process Cytoplasm Cyclin-dependent Protein Serine/threonine Kinase Regulator Activity Protein Metabolic Process Macromolecule Catabolic Process Cyclin-dependent Protein Kinase Holoenzyme Complex Protein Modification By Small Protein Conjugation Protein Ubiquitination Regulation Of Cell Cycle Proteolysis Macromolecule Metabolic Process Regulation Of Primary Metabolic Process Protein Domain Specific Binding Cellular Response To Stress Proteasome-mediated Ubiquitin-dependent Protein Catabolic Process Regulation Of Protein Modification Process Regulation Of Protein Metabolic Process Intracellular Signal Transduction Catabolic Process Protein Polyubiquitination Protein Localization To Nucleus Transferase Activity NLS-dependent Protein Nuclear Import Complex Regulation Of Macromolecule Metabolic Process Protein Catabolic Process Regulation Of Metabolic Process Ubiquitin-protein Transferase Activity NLS-bearing Protein Import Into Nucleus Regulation Of Nucleobase-containing Compound Metabolic Process Proteasomal Protein Catabolic Process Cyclin-dependent Protein Serine/threonine Kinase Activator Activity Regulation Of DNA Metabolic Process Protein Import Into Nucleus Import Into Nucleus Positive Regulation Of Protein Metabolic Process Positive Regulation Of Mitotic Cell Cycle Ubiquitin Protein Ligase Binding Protein Kinase Binding Phosphoserine Residue Binding
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