ESS2 and LYST

Number of citations of the paper that reports this interaction (PubMedID 11984006)
0

Data Source:
BioGRID (two hybrid)
HPRD (two hybrid, in vitro)

		ESS2	LYST
Description		ess-2 spliceosome associated protein	lysosomal trafficking regulator
Image			No pdb structure
GO Annotations	Cellular Component	Nucleus Spliceosomal Complex Catalytic Step 2 Spliceosome	Cytoplasm Microtubule Cytoskeleton
	Molecular Function	Protein Binding	Protein Binding
	Biological Process	MRNA Splicing, Via Spliceosome MRNA Processing Nervous System Development RNA Splicing	Lymphocyte Mediated Immunity Phagocytosis Immune Response Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus Defense Response To Other Organism
Pathways
Drugs
Diseases			Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS			Basophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 19838195 26502338)
Interacting Genes		33 interacting genes: ARMC7 CCDC57 CDK5RAP3 CEP55 CPSF7 CRP DGCR6 DHX16 EHMT2 EXOC8 EXOSC7 HOOK1 ITCH KRT31 LYST NEDD4 OGT OIP5 PFDN1 PRPF38B PRRC2B QARS1 RACK1 RBM22 RBM4 SMARCD1 THOC1 TRAK1 TTC14 UTP6 VIM WNK2 YAP1	23 interacting genes: ATN1 CALM1 CELF4 CNTROB CPAP CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ ZNF521
Entrez ID		8220	1130
HPRD ID		03452	06060
Ensembl ID		ENSG00000100056	ENSG00000143669
Uniprot IDs		F8WEF8 Q96DF8	Q99698
PDB IDs		8C6J 8RO2 9FMD
Enriched GO Terms of Interacting Partners?		RNA Metabolic Process Cyclin Binding RNA Processing MRNA Metabolic Process MRNA Processing RNA Splicing Lysosomal Transport Positive Regulation Of Stem Cell Population Maintenance Endosome To Lysosome Transport Vacuolar Transport Negative Regulation Of MAPK Cascade RNA Binding Regulation Of Stem Cell Population Maintenance Spliceosomal Complex Molecular Adaptor Activity Proline-rich Region Binding Regulation Of Macroautophagy Pre-mRNA Binding	Protein Domain Specific Binding Regulation Of Receptor Signaling Pathway Via JAK-STAT Calcium Channel Inhibitor Activity Astral Microtubule Organization Ribonucleoprotein Complex Alternative MRNA Splicing, Via Spliceosome Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Multivesicular Body Organization Multivesicular Body Assembly Centriole Assembly
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