LYST and PCBP4

Number of citations of the paper that reports this interaction (PubMedID 11984006)
0

Data Source:
BioGRID (two hybrid)

		LYST	PCBP4
Description		lysosomal trafficking regulator	poly(rC) binding protein 4
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Cytoplasm Microtubule Cytoskeleton	Nucleus Cytoplasm Cytosol Ribonucleoprotein Complex
	Molecular Function	Protein Binding	Nucleic Acid Binding DNA Binding RNA Binding MRNA Binding MRNA 3'-UTR Binding Protein Binding
	Biological Process	Lymphocyte Mediated Immunity Phagocytosis Immune Response Protein Transport Leukocyte Chemotaxis Melanosome Organization Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Mast Cell Secretory Granule Organization Natural Killer Cell Mediated Cytotoxicity Defense Response To Bacterium Defense Response To Protozoan Pigmentation Defense Response To Virus Defense Response To Other Organism	Regulation Of Transcription By RNA Polymerase II Regulation Of Gene Expression Regulation Of MRNA Stability Negative Regulation Of MRNA Splicing, Via Spliceosome Regulation Of MRNA Metabolic Process
Pathways			TP53 Regulates Transcription of Genes Involved in G1 Cell Cycle Arrest Transcriptional activation of cell cycle inhibitor p21 FOXO-mediated transcription of cell cycle genes
Drugs
Diseases		Other phagocyte defects, including the following eight diseases: Chediak-Higashi syndrome; Griscelli syndrome, type 1 (GS1); Griscelli syndrome, type 2 (GS2); Griscelli syndrome, type 3 (GS3); beta-actin deficiency; Neutrophil-specific granule deficiency; Myeloperoxidase deficiency; Glucose 6-phosphate dehydrogenase deficiency; Shwachman syndrome
GWAS		Basophil percentage of white cells ( 32888494) Lymphocyte count ( 32888494) Post bronchodilator FEV1/FVC ratio ( 26634245) Systemic lupus erythematosus ( 19838195 26502338)
Interacting Genes		23 interacting genes: ATN1 CALM1 CELF4 CNTROB CPAP CSNK2B DNAJC14 EFS ESRRA ESS2 HGS HNRNPM KPNB1 MED12 MRPL17 MRPS31 NCDN PCBP4 TNNI3 VTA1 YWHAB YWHAQ ZNF521	7 interacting genes: LYST PBRM1 PCBP1 QKI RBFOX1 RNF138 WBP11
Entrez ID		1130	57060
HPRD ID		06060	16343
Ensembl ID		ENSG00000143669	ENSG00000090097
Uniprot IDs		Q99698	C9J0A4 P57723
PDB IDs
Enriched GO Terms of Interacting Partners?		Protein Domain Specific Binding Regulation Of Receptor Signaling Pathway Via JAK-STAT Calcium Channel Inhibitor Activity Astral Microtubule Organization Ribonucleoprotein Complex Alternative MRNA Splicing, Via Spliceosome Late Endosome To Vacuole Transport Via Multivesicular Body Sorting Pathway Centriole Replication Negative Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of RNA Splicing Regulation Of Cardiac Muscle Contraction By Calcium Ion Signaling Multivesicular Body Organization Multivesicular Body Assembly Centriole Assembly	Single-stranded DNA Binding Nucleic Acid Metabolic Process Nucleobase-containing Compound Metabolic Process RNA Metabolic Process MRNA Binding RNA Splicing Internal N(7)-methylguanine-containing RNA Reader Activity Mast Cell Secretory Granule Organization Sequence-specific Single Stranded DNA Binding Myofibroblast Contraction Cytoplasmic Stress Granule MRNA Processing Regulation Of MRNA Splicing, Via Spliceosome Negative Regulation Of MiRNA Catabolic Process Nucleic Acid Binding Regulation Of MRNA Processing Spliceosome-depend Formation Of Circular RNA MRNA Metabolic Process RNA Transport RNA Binding Endosome To Lysosome Transport Via Multivesicular Body Sorting Pathway Viral RNA Genome Replication Macromolecule Metabolic Process Regulation Of RNA Splicing Microglia Differentiation Negative Regulation Of Macrophage Differentiation Nucleobase-containing Compound Transport Negative Regulation Of 3'-UTR-mediated MRNA Stabilization DNA Double-strand Break Processing Involved In Repair Via Single-strand Annealing Nuclear Stress Granule RNA Processing Vascular Associated Smooth Muscle Cell Differentiation
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