CHAF1B and PRELP

		CHAF1B	PRELP
Description		chromatin assembly factor 1 subunit B	proline and arginine rich end leucine rich repeat protein
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex CAF-1 Complex	Extracellular Region Extracellular Space Golgi Lumen Extracellular Matrix Lysosomal Lumen Extracellular Exosome Extracellular Vesicle
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Unfolded Protein Binding	Extracellular Matrix Structural Constituent Heparin Binding Extracellular Matrix Structural Constituent Conferring Compression Resistance
	Biological Process	DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly DNA Damage Response	Skeletal System Development Cellular Senescence
Pathways			Keratan sulfate biosynthesis Keratan sulfate degradation Defective CHST6 causes MCDC1 Defective ST3GAL3 causes MCT12 and EIEE15 Defective B4GALT1 causes B4GALT1-CDG (CDG-2d)
Drugs
Diseases
GWAS		Creatinine levels ( 29403010) Height ( 31562340) Pulmonary function ( 23932459)	Attention deficit hyperactivity disorder (inattention symptoms) ( 32595297)
Interacting Genes		18 interacting genes: APP ASF1A ASF1B CBR1 CDK1 CDK2 CHAF1A CUX1 H3-4 H3C6 MAL2 PGM1 PLEKHH1 PRELP RBBP4 SETD4 SUMO2 ZNF879	7 interacting genes: CHAF1B COL1A1 COL2A1 FBLN2 FN1 HSPG2 NID1
Entrez ID		8208	5549
HPRD ID		03147	03556
Ensembl ID		ENSG00000159259	ENSG00000188783
Uniprot IDs		Q13112	P51888
PDB IDs		7Y5K 7Y5L 7Y5O 7Y5U 7Y5V 7Y60 7Y61 8IQF 8IQG 8J6S 8J6T
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Nucleosome Organization Protein-DNA Complex Assembly Cyclin-dependent Protein Kinase Activity CAF-1 Complex DNA Replication Histone Kinase Activity Protein-containing Complex Assembly Chromosome, Telomeric Region Protein-containing Complex Organization Histone Chaperone Activity Protein-containing Complex DNA Repair Cellular Component Assembly Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin Binding Response To Copper Ion Extracellular Exosome Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity DNA Metabolic Process Pronuclear Fusion DNA Damage Response Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Histone Binding Chromatin Binding G2/M Transition Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Regulation Of Transcription By RNA Polymerase II Lipoprotein Particle Positive Regulation Of Protein Import 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Cell Cycle G2/M Phase Transition Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex	Extracellular Matrix Structural Constituent Extracellular Matrix Proteoglycan Binding Basement Membrane Regulation Of Cell-substrate Adhesion Regulation Of Cell Adhesion Fibrillar Collagen Trimer Platelet-derived Growth Factor Binding Positive Regulation Of Cell-substrate Adhesion Extracellular Region Cartilage Development Involved In Endochondral Bone Morphogenesis Endochondral Ossification Extracellular Matrix Binding Extracellular Matrix Organization Extracellular Matrix Structural Constituent Conferring Tensile Strength Extracellular Structure Organization Anatomical Structure Formation Involved In Morphogenesis Endoplasmic Reticulum Lumen Collagen Fibril Organization Collagen Binding Cellular Response To Vitamin E Collagen Trimer System Development Cartilage Development Collagen Type I Trimer Protease Binding Cellular Response To Fluoride Positive Regulation Of Cell Adhesion Cell-matrix Adhesion Collagen V Binding Skeletal System Morphogenesis Ossification Collagen Type II Trimer Negative Regulation Of Monocyte Activation Positive Regulation Of Substrate-dependent Cell Migration, Cell Attachment To Substrate CAF-1 Complex Animal Organ Development Calcium Ion Binding Response To Fluoride Sensory Perception Of Mechanical Stimulus Sensory Perception Of Sound Extracellular Space Calcium-independent Cell-matrix Adhesion Integrin Binding Cell-substrate Adhesion Collagen Type XI Trimer Anterior Head Development Intramembranous Ossification Visual Perception Skeletal System Development
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