CHAF1B and PGM1

		CHAF1B	PGM1
Description		chromatin assembly factor 1 subunit B	phosphoglucomutase 1
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GO Annotations	Cellular Component	Chromatin Nucleus Nucleoplasm Cytoplasm Cytosol Protein-containing Complex CAF-1 Complex	Extracellular Region Cytoplasm Cytosol Extracellular Exosome Tertiary Granule Lumen Ficolin-1-rich Granule Lumen
	Molecular Function	Chromatin Binding Protein Binding Histone Binding Unfolded Protein Binding	Magnesium Ion Binding Phosphoglucomutase Activity Protein Binding Isomerase Activity Intramolecular Phosphotransferase Activity Metal Ion Binding
	Biological Process	DNA Replication DNA Repair Chromatin Organization Nucleosome Assembly DNA Replication-dependent Chromatin Assembly DNA Damage Response	Carbohydrate Metabolic Process Glucose Metabolic Process Gluconeogenesis Glycolytic Process Galactose Catabolic Process Via UDP-galactose, Leloir Pathway
Pathways			Glycogen synthesis Defective PGM1 causes PGM1-CDG Neutrophil degranulation Glycogen breakdown (glycogenolysis) Galactose catabolism
Drugs			Alpha-D-Glucose 1,6-Bisphosphate Alpha-D-Glucose-1-Phosphate-6-Vanadate
Diseases
GWAS		Creatinine levels ( 29403010) Height ( 31562340) Pulmonary function ( 23932459)	Alcohol consumption (transferrin glycosylation) ( 21665994) Type 1 diabetes ( 19430480 32005708 33830302 34012112 34127860) Type 2 diabetes ( 32499647)
Interacting Genes		18 interacting genes: APP ASF1A ASF1B CBR1 CDK1 CDK2 CHAF1A CUX1 H3-4 H3C6 MAL2 PGM1 PLEKHH1 PRELP RBBP4 SETD4 SUMO2 ZNF879	21 interacting genes: APP CHAF1B DNAJB6 DYRK3 ENO3 HSPB2 KIF1B LINC01554 NLRP3 OGT PAXIP1 PEA15 POT1 S100A1 S100B TERF1 TERF2IP TINF2 TMEM132D USP4 XRN2
Entrez ID		8208	5236
HPRD ID		03147	01389
Ensembl ID		ENSG00000159259	ENSG00000079739
Uniprot IDs		Q13112	B4DDQ8 B7Z6C2 P36871
PDB IDs		7Y5K 7Y5L 7Y5O 7Y5U 7Y5V 7Y60 7Y61 8IQF 8IQG 8J6S 8J6T	5EPC 5F9C 5HSH 5JN5 5TR2 5VBI 5VEC 5VG7 5VIN 6SNO 6SNP 6SNQ 6UIQ 6UO6 7S0W 7S77
Enriched GO Terms of Interacting Partners?		DNA Replication-dependent Chromatin Assembly Chromatin Remodeling Nucleosome Assembly Chromatin Organization Nucleosome Organization Protein-DNA Complex Assembly Cyclin-dependent Protein Kinase Activity CAF-1 Complex DNA Replication Histone Kinase Activity Protein-containing Complex Assembly Chromosome, Telomeric Region Protein-containing Complex Organization Histone Chaperone Activity Protein-containing Complex DNA Repair Cellular Component Assembly Cyclin-dependent Protein Serine/threonine Kinase Activity Cyclin Binding Response To Copper Ion Extracellular Exosome Amyloid-beta Complex Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Positive Regulation Of Toll Signaling Pathway Prostaglandin E2 9-reductase Activity 15-hydroxyprostaglandin Dehydrogenase (NADP+) Activity DNA Metabolic Process Pronuclear Fusion DNA Damage Response Positive Regulation Of DNA Replication Cyclin-dependent Protein Kinase Holoenzyme Complex Histone Binding Chromatin Binding G2/M Transition Of Mitotic Cell Cycle Acetylcholine Receptor Activator Activity Regulation Of Transcription By RNA Polymerase II Lipoprotein Particle Positive Regulation Of Protein Import 15-hydroxyprostaglandin-D Dehydrogenase (NADP+) Activity S-nitrosoglutathione Reductase (NADPH) Activity Cell Cycle G2/M Phase Transition Mitotic DNA-templated DNA Replication Cyclin B1-CDK1 Complex Cyclin A1-CDK1 Complex Cyclin A2-CDK1 Complex Y Chromosome Positive Regulation Of Heterochromatin Formation Cyclin A1-CDK2 Complex	Shelterin Complex Nuclear Telomere Cap Complex Telomere Capping Telomeric DNA Binding Negative Regulation Of Telomere Maintenance G-rich Strand Telomeric DNA Binding Positive Regulation Of Telomere Maintenance Negative Regulation Of Telomere Maintenance Via Telomerase Telomere Maintenance Via Telomerase Negative Regulation Of Chromosome Organization RNA-templated DNA Biosynthetic Process Chorion Development Telomere Maintenance Via Telomere Lengthening Telomere Maintenance Negative Regulation Of DNA Biosynthetic Process Negative Regulation Of Telomere Maintenance Via Telomere Lengthening Positive Regulation Of Chromosome Organization Regulation Of Telomere Maintenance Telomere Assembly Telomere Organization Regulation Of Telomere Maintenance Via Telomerase Negative Regulation Of DNA Metabolic Process Positive Regulation Of DNA Metabolic Process Regulation Of Telomere Maintenance Via Telomere Lengthening Telomeric D-loop Disassembly Chromosome, Telomeric Region Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Non-canonical NF-kappaB Signal Transduction Telomeric Loop Disassembly Protein Localization To Chromosome, Telomeric Region RAGE Receptor Binding Negative Regulation Of Macromolecule Biosynthetic Process S100 Protein Binding Negative Regulation Of Metabolic Process Negative Regulation Of Biosynthetic Process Nucleoplasm Negative Regulation Of Cellular Component Organization Regulation Of DNA Biosynthetic Process DNA Biosynthetic Process DNA Metabolic Process Regulation Of Chromosome Organization Regulation Of TORC1 Signaling Regulation Of Non-canonical NF-kappaB Signal Transduction Regulation Of DNA Metabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Nucleus Unfolded Protein Binding Regulation Of Cellular Response To Stress Identical Protein Binding Chromosome Organization
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