VANGL1 and DVL2

Number of citations of the paper that reports this interaction (PubMedID 15456783)
0

Data Source:
HPRD (in vivo, two hybrid, in vitro)

		VANGL1	DVL2
Description		VANGL planar cell polarity protein 1	dishevelled segment polarity protein 2
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GO Annotations	Cellular Component	Extracellular Region Plasma Membrane Membrane Lateral Plasma Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol Plasma Membrane Membrane Aggresome Lateral Plasma Membrane Nuclear Body Clathrin-coated Vesicle Cytoplasmic Vesicle Apical Part Of Cell Clathrin-coated Endocytic Vesicle
	Molecular Function	Protein Binding	Frizzled Binding Protein Binding Protein Kinase Binding Protein Domain Specific Binding Protein-macromolecule Adaptor Activity Small GTPase Binding Identical Protein Binding
	Biological Process	Pigmentation Wnt Signaling Pathway, Planar Cell Polarity Pathway Mucociliary Clearance	Neural Tube Closure Heart Looping Heart Morphogenesis Outflow Tract Morphogenesis Regulation Of DNA-templated Transcription Segment Specification Heart Development Intracellular Protein Localization Wnt Signaling Pathway Convergent Extension Involved In Neural Plate Elongation Regulation Of Actin Cytoskeleton Organization Segmentation Intracellular Signal Transduction Non-canonical Wnt Signaling Pathway Regulation Of Cell Population Proliferation Positive Regulation Of Transcription By RNA Polymerase II Positive Regulation Of JNK Cascade Convergent Extension Involved In Organogenesis Canonical Wnt Signaling Pathway Wnt Signaling Pathway, Planar Cell Polarity Pathway Cochlea Morphogenesis Positive Regulation Of Neuron Projection Arborization Positive Regulation Of Signal Transduction By P53 Class Mediator
Pathways		RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOD GTPase cycle RHOQ GTPase cycle RHOH GTPase cycle RHOG GTPase cycle RHOJ GTPase cycle RHOU GTPase cycle RAC3 GTPase cycle RHOV GTPase cycle RHOF GTPase cycle RND3 GTPase cycle RND2 GTPase cycle RND1 GTPase cycle	TCF dependent signaling in response to WNT WNT mediated activation of DVL Signaling by Hippo PCP/CE pathway PCP/CE pathway Asymmetric localization of PCP proteins Degradation of DVL Disassembly of the destruction complex and recruitment of AXIN to the membrane Disassembly of the destruction complex and recruitment of AXIN to the membrane WNT5A-dependent internalization of FZD4 Negative regulation of TCF-dependent signaling by DVL-interacting proteins RHO GTPases Activate Formins Cargo recognition for clathrin-mediated endocytosis Clathrin-mediated endocytosis WNT5:FZD7-mediated leishmania damping WNT5:FZD7-mediated leishmania damping
Drugs
Diseases		Spina bifida Caudal regression syndrome and Sirenomelia
GWAS		Coronary artery disease ( 33020668) Gut microbiota (bacterial taxa) ( 27694959) Iron status biomarkers (ferritin levels) ( 33536631) Itch intensity from mosquito bite adjusted by bite size ( 28199695) Optic disc size ( 31809533)	Metabolite levels ( 31628463)
Interacting Genes		13 interacting genes: CD82 DVL1 DVL2 DVL3 FES GMFG LINC00839 NT5C3A RAPGEF5 SMYD3 SRPK1 THAP2 UBC	106 interacting genes: ABL1 AKAP9 AP1M1 AP2M1 AQP9 ARHGEF39 ARR3 ARRB1 ARRB2 ATN1 AXIN1 BAG3 BAHD1 BCL6 BEND7 BYSL CARD9 CCDC33 CPSF7 CSNK1E CTBP2 CUL1 DAAM1 DCUN1D1 DDI1 DPPA2 DYNLT1 EIF1B ELOA2 ENKD1 FAM161A FAM90A1 FZD4 GABARAP GABARAPL1 GMCL2 GOLGA2 GRAP2 GRB2 HIP1 IHO1 LMO3 LRRK2 MAGOHB MAP1LC3A MCRS1 NOL12 NUP62CL NUP88 OTULIN PARD6A PCBD1 PLA2G12A POLI PPM1A PPP1R16B PRKAA1 PRKCA PRKCB PRKCG PRPF3 PRPF31 PSMF1 RAC1 RAP1B RBFOX1 RBPMS RHOA RHOXF2 RNF185 RNPS1 RUNX2 RUSC1 SCNM1 SMURF1 SNF8 SNIP1 SORBS3 SSX2IP TAB1 TDP2 THAP1 TIFA TLE5 TP53 TPM3 TRAF2 U2AF2 UBAC1 UIMC1 USP5 USP9X VANGL1 VHL WAS WT1 WWP2 YES1 ZBTB48 ZBTB8A ZGPAT ZNF165 ZNF250 ZNF263 ZNF410 ZNF581
Entrez ID		81839	1856
HPRD ID		18279	03690
Ensembl ID		ENSG00000173218	ENSG00000004975
Uniprot IDs		Q8TAA9	O14641
PDB IDs		8ZXD 9JK6 9JK8 9JK9	2REY 3CBX 3CBY 3CBZ 3CC0 4WIP 5LNP 5SUY 5SUZ 6IW3 6JCK 8WM9 8WMA 8WWR 8YR7
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Neuron Projection Arborization Regulation Of Neuron Projection Arborization Convergent Extension Involved In Neural Plate Elongation Wnt Signaling Pathway, Planar Cell Polarity Pathway Frizzled Binding Convergent Extension Involved In Organogenesis Non-canonical Wnt Signaling Pathway Convergent Extension Involved In Gastrulation Regulation Of Cell Morphogenesis Convergent Extension Canonical Wnt Signaling Pathway Positive Regulation Of Cell Projection Organization Cochlea Morphogenesis Regulation Of Cytoskeleton Organization Positive Regulation Of Protein Localization To Presynapse Wnt Signaling Pathway Small GTPase Binding Clathrin-coated Vesicle Outflow Tract Morphogenesis Lateral Plasma Membrane Heart Looping Embryonic Heart Tube Morphogenesis Regulation Of Cell Projection Organization Actin Filament Debranching TRNA 2'-phosphotransferase Activity Regulation Of Actin Cytoskeleton Organization Protein Phosphorylation Beta-catenin Binding Nuclear Body Regulation Of Actin Filament-based Process Positive Regulation Of JNK Cascade Phosphorylation Epithelial Tube Morphogenesis Regulation Of Anatomical Structure Morphogenesis Cytoplasmic Vesicle Histone H3K36 Dimethyltransferase Activity	Protein Binding Regulation Of RNA Metabolic Process Regulation Of Primary Metabolic Process Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of Macromolecule Metabolic Process Nucleus Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Regulation Of Metabolic Process Regulation Of Macromolecule Biosynthetic Process Regulation Of Gene Expression Non-canonical Wnt Signaling Pathway Positive Regulation Of Metabolic Process Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Metabolic Process Wnt Signaling Pathway Regulation Of Signal Transduction Intracellular Signaling Cassette Negative Regulation Of Macromolecule Metabolic Process Regulation Of Intracellular Signal Transduction Calcium,diacylglycerol-dependent Serine/threonine Kinase Activity Regulation Of Protein Metabolic Process Positive Regulation Of Intracellular Signal Transduction Cytosol Protein Modification By Small Protein Conjugation Protein Ubiquitination Wnt Signaling Pathway, Planar Cell Polarity Pathway Regulation Of Protein Modification Process Nucleoplasm Cytoplasm Regulation Of Signaling Regulation Of Cell Communication Regulation Of Protein Ubiquitination Negative Regulation Of Protein Metabolic Process Negative Regulation Of Biosynthetic Process Protein Modification Process Cellular Component Assembly Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Macromolecule Biosynthetic Process Enzyme Binding Cytoskeleton Regulation Of Transcription By RNA Polymerase II Intracellular Signal Transduction Macromolecule Metabolic Process Positive Regulation Of Signal Transduction Regulation Of MAPK Cascade Negative Regulation Of RNA Metabolic Process Post-translational Protein Modification Autophagy
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