ITM2C and PRODH

		ITM2C	PRODH
Description		integral membrane protein 2C	proline dehydrogenase 1
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Lysosome Lysosomal Membrane Golgi Apparatus Plasma Membrane Membrane Perinuclear Region Of Cytoplasm Extracellular Exosome	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix
	Molecular Function	Amyloid-beta Binding Protein Binding ATP Binding	Proline Dehydrogenase Activity Oxidoreductase Activity FAD Binding
	Biological Process	Negative Regulation Of Neuron Projection Development Neuron Differentiation Negative Regulation Of Amyloid Precursor Protein Biosynthetic Process Positive Regulation Of Extrinsic Apoptotic Signaling Pathway	Proline Metabolic Process L-proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress L-proline Catabolic Process To L-glutamate Trans-4-hydroxy-L-proline Catabolic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway
Pathways			Proline catabolism
Drugs			Proline
Diseases			Hyperprolinemia (HP)
GWAS		Mean corpuscular hemoglobin ( 32888494) Mean corpuscular volume ( 32888494) Mean reticulocyte volume ( 32888494) Mean spheric corpuscular volume ( 32888494)	Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235 33031748) White blood cell count ( 32888494)
Interacting Genes		14 interacting genes: AGAP1 BACE1 CCL4L2 CFTR CXCL9 FNDC9 FURIN MTNR1B OLFM4 PRODH RNF7 SLC22A2 STT3A UPK2	7 interacting genes: GGT3P GSC2 ITM2C RANBP1 SEPTIN5 SKIC2 TBX1
Entrez ID		81618	5625
HPRD ID		17167	08433
Ensembl ID		ENSG00000135916	ENSG00000100033
Uniprot IDs		B8ZZM6 Q9NQX7	E7EQL6 O43272
PDB IDs
Enriched GO Terms of Interacting Partners?			Social Behavior
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