PRODH and RANBP1

		PRODH	RANBP1
Description		proline dehydrogenase 1	RAN binding protein 1
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Nucleus Nuclear Envelope Nuclear Pore Cytoplasm Centrosome Cytosol
	Molecular Function	Proline Dehydrogenase Activity Oxidoreductase Activity FAD Binding	GDP-dissociation Inhibitor Activity GTPase Activator Activity Protein Binding Small GTPase Binding Cadherin Binding
	Biological Process	Proline Metabolic Process L-proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress L-proline Catabolic Process To L-glutamate Trans-4-hydroxy-L-proline Catabolic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Nucleocytoplasmic Transport Signal Transduction Positive Regulation Of Mitotic Centrosome Separation
Pathways		Proline catabolism	Rev-mediated nuclear export of HIV RNA
Drugs		Proline	Copper Phenethyl Isothiocyanate
Diseases		Hyperprolinemia (HP)
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235 33031748) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: GGT3P GSC2 ITM2C RANBP1 SEPTIN5 SKIC2 TBX1	8 interacting genes: CD93 CEBPA MDM2 NUPR1 PRODH RAN RANGRF RCC1
Entrez ID		5625	5902
HPRD ID		08433	03110
Ensembl ID		ENSG00000100033	ENSG00000099901
Uniprot IDs		E7EQL6 O43272	A0A140VK94 B3KUP2 B4DE76 F6WQW2 P43487
PDB IDs			1K5D 1K5G
Enriched GO Terms of Interacting Partners?		Social Behavior	Positive Regulation Of Proteolysis Involved In Protein Catabolic Process Positive Regulation Of Proteasomal Protein Catabolic Process Microtubule Cytoskeleton Organization Involved In Mitosis Mitotic Spindle Organization Chromatin Binding Spindle Organization Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Response To Steroid Hormone Regulation Of Intrinsic Apoptotic Signaling Pathway Protein Domain Specific Binding Nucleoplasm Protein-containing Complex Acute Inflammatory Response Positive Regulation Of Nucleocytoplasmic Transport RNA Polymerase I Transcription Regulatory Region Sequence-specific DNA Binding Protein Heterodimerization Activity Response To Formaldehyde Cellular Response To Vitamin B1 Regulation Of Protein Catabolic Process Response To Vitamin Positive Regulation Of Proteasomal Ubiquitin-dependent Protein Catabolic Process Regulation Of Proteolysis Response To Vitamin B2 Regulation Of Cell Cycle C/EBP Complex Microtubule Cytoskeleton Organization Spindle Assembly Positive Regulation Of Intracellular Protein Transport Regulation Of Apoptotic Signaling Pathway Positive Regulation Of Protein Localization Signal Transduction By P53 Class Mediator Response To Toxic Substance Proline Dehydrogenase Activity RNA Nuclear Export Complex SnRNA Import Into Nucleus Pre-miRNA Export From Nucleus Positive Regulation Of Membrane Depolarization During Cardiac Muscle Cell Action Potential Regulation Of Bundle Of His Cell Action Potential Regulation Of Heart Rate Positive Regulation Of Ubiquitin-dependent Protein Catabolic Process CHOP-C/EBP Complex Response To Vitamin B1 Regulation Of Cellular Localization Response To Water-immersion Restraint Stress Regulation Of Nucleocytoplasmic Transport Cellular Response To Actinomycin D L-proline Catabolic Process To L-glutamate Negative Regulation Of Type B Pancreatic Cell Proliferation
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