PRODH and SEPTIN5

		PRODH	SEPTIN5
Description		proline dehydrogenase 1	septin 5
Image		No pdb structure
GO Annotations	Cellular Component	Nucleoplasm Mitochondrion Mitochondrial Inner Membrane Mitochondrial Matrix	Cytoplasm Cytoskeleton Plasma Membrane Septin Ring Synaptic Vesicle Microtubule Cytoskeleton Septin Complex Cell Division Site
	Molecular Function	Proline Dehydrogenase Activity Oxidoreductase Activity FAD Binding	Nucleotide Binding GTPase Activity Structural Molecule Activity Protein Binding GTP Binding Identical Protein Binding Molecular Adaptor Activity
	Biological Process	Proline Metabolic Process L-proline Catabolic Process Intrinsic Apoptotic Signaling Pathway In Response To Oxidative Stress L-proline Catabolic Process To L-glutamate Trans-4-hydroxy-L-proline Catabolic Process Regulation Of Oxidative Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway	Intracellular Protein Localization Synaptic Vesicle Targeting Regulation Of Exocytosis Adult Behavior Social Behavior Cell Division Cytoskeleton-dependent Cytokinesis Regulation Of Synaptic Vesicle Exocytosis
Pathways		Proline catabolism
Drugs		Proline
Diseases		Hyperprolinemia (HP)
GWAS		Metabolic traits ( 21886157) Metabolite levels ( 31628463) Neutrophil count ( 32888494) Plasma free amino acid levels (adjusted for one other PFAA) ( 30659259) Plasma free amino acid levels (adjusted for twenty other PFAAs) ( 30659259) Plasma free proline levels ( 30659259) Platelet count ( 32888494) Serum metabolite concentrations in chronic kidney disease ( 29545352) Serum metabolite levels ( 25569235 33031748) White blood cell count ( 32888494)
Interacting Genes		7 interacting genes: GGT3P GSC2 ITM2C RANBP1 SEPTIN5 SKIC2 TBX1	22 interacting genes: APP CDK5R1 DDIT4L KAT7 KIDINS220 LSM8 MAGEA2 MAGEA2B MAPK6 MYOG PFN2 PLEKHF2 PRKN PRODH SEPTIN1 SEPTIN2 SEPTIN4 SEPTIN7 SEPTIN8 SPG21 STX1A STX4
Entrez ID		5625	5413
HPRD ID		08433	04100
Ensembl ID		ENSG00000100033	ENSG00000184702
Uniprot IDs		E7EQL6 O43272	Q99719 X5DNA9
PDB IDs			6WCU
Enriched GO Terms of Interacting Partners?		Social Behavior	Septin Ring Septin Complex Cell Division Site Sperm Annulus Cytoskeleton-dependent Cytokinesis Regulation Of Exocytosis Regulation Of Vesicle-mediated Transport Molecular Adaptor Activity Presynapse Axon Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Regulation Of Protein Localization Positive Regulation Of Protein Ubiquitination Negative Regulation Of Protein Acetylation Microtubule Cytoskeleton Regulation Of Spontaneous Synaptic Transmission Synaptic Vesicle Positive Regulation Of Post-translational Protein Modification Modulation Of Excitatory Postsynaptic Potential Regulation Of Establishment Of Protein Localization GTPase Activity Cellular Response To Manganese Ion Neuron Projection Regulation Of Secretion By Cell Negative Regulation Of Protein Sumoylation Regulation Of Transport GTP Binding Regulation Of Intrinsic Apoptotic Signaling Pathway Cell Projection Regulation Of Secretion Positive Regulation Of Protein Modification Process Regulation Of Protein Ubiquitination SNARE Complex Assembly Regulation Of Apoptotic Signaling Pathway Synapse Regulation Of Protein Modification Process Positive Regulation Of Ubiquitin-protein Transferase Activity Dopaminergic Synapse Regulation Of Amine Transport Response To Manganese Ion Intracellular Protein Localization Positive Regulation Of Tumor Necrosis Factor-mediated Signaling Pathway Regulation Of Neurotransmitter Secretion Regulation Of Protein Transport Postsynapse Collateral Sprouting Cellular Response To Catecholamine Stimulus Regulation Of Post-translational Protein Modification Neurotransmitter Transport Schaffer Collateral - CA1 Synapse
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