COL14A1 and ENO1

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		COL14A1	ENO1
Description		collagen type XIV alpha 1 chain	enolase 1
Image		No pdb structure
GO Annotations	Cellular Component	Extracellular Region Collagen Trimer Collagen Type XIV Trimer Interstitial Matrix Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Nuclear Outer Membrane Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane M Band Extracellular Exosome
	Molecular Function	RNA Binding Extracellular Matrix Structural Constituent Collagen Binding Extracellular Matrix Structural Constituent Conferring Tensile Strength Protein-macromolecule Adaptor Activity	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding GTPase Binding
	Biological Process	Ventricular Cardiac Muscle Tissue Development Cell Adhesion Extracellular Matrix Organization Collagen Fibril Organization Homeostasis Of Number Of Cells Within A Tissue Regulation Of Cell Growth Involved In Cardiac Muscle Cell Development Cell-cell Adhesion	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Negative Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process
Pathways		Collagen degradation Collagen biosynthesis and modifying enzymes Assembly of collagen fibrils and other multimeric structures Collagen chain trimerization	Glycolysis Gluconeogenesis Manipulation of host energy metabolism
Drugs			Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Adverse response to drug ( 30420678) Appendicular lean mass ( 33097823) Cerebrospinal T-tau levels ( 28247064) Gastritis ( 25317112) Parasitemia in Tripanosoma cruzi seropositivity ( 24324551) Visceral fat ( 30942860)	Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)
Interacting Genes		5 interacting genes: APP CD44 DCN ENO1 RNF10	68 interacting genes: AGTPBP1 ALDOA AMBP ANK3 ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CHKA CLK1 COL14A1 CYSLTR2 DES DRC2 DUX4 FANCA FHL1 FLNC FNDC3B FXR1 FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 OGT P4HB PAF1 PCNA PDE4B PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TNFRSF14 TRAPPC2 TTN TUBA1A UBE3A UPF2 YWHAQ YWHAZ ZBTB44
Entrez ID		7373	2023
HPRD ID		00379	01400
Ensembl ID		ENSG00000187955	ENSG00000074800
Uniprot IDs		Q05707	A0A024R4F1 A0A2R8Y6G6 P06733
PDB IDs			2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK 8TRL
Enriched GO Terms of Interacting Partners?		Regulation Of Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Metabolic Process Amyloid-beta Complex Regulation Of ATP Metabolic Process Growth Cone Lamellipodium Regulation Of Response To Calcium Ion Amylin Binding Regulation Of Purine Nucleotide Metabolic Process Negative Regulation Of Signaling Positive Regulation Of Toll Signaling Pathway Negative Regulation Of Signal Transduction Regulation Of Cellular Response To Stress Regulation Of Apoptotic Signaling Pathway Negative Regulation Of Cell Communication Regulation Of System Process Golgi Lumen Acetylcholine Receptor Activator Activity PTB Domain Binding Collateral Sprouting In Absence Of Injury Regulation Of Protein Import Cell Surface Endosome To Plasma Membrane Transport Vesicle Positive Regulation Of Endothelin Production Growth Cone Filopodium Positive Regulation Of Nucleobase-containing Compound Metabolic Process Positive Regulation Of Small Molecule Metabolic Process Lipoprotein Particle Phospholipase D-activating G Protein-coupled Receptor Signaling Pathway Positive Regulation Of Protein Import Regulation Of Nervous System Process Microglia Development Regulation Of Intracellular Signal Transduction Positive Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Monocyte Aggregation Negative Regulation Of Intrinsic Apoptotic Signaling Pathway Macrophage Migration Inhibitory Factor Receptor Complex Monocyte Aggregation Phosphopyruvate Hydratase Complex Phosphopyruvate Hydratase Activity Response To Norepinephrine Regulation Of Endoplasmic Reticulum Stress-induced Neuron Intrinsic Apoptotic Signaling Pathway Cellular Response To Norepinephrine Stimulus Astrocyte Activation Involved In Immune Response Positive Regulation Of ERK1 And ERK2 Cascade Low-density Lipoprotein Particle Mediated Signaling Carbohydrate Derivative Catabolic Process Positive Regulation Of Proteolysis Intermediate-density Lipoprotein Particle Axon Midline Choice Point Recognition Positive Regulation Of Amyloid Fibril Formation	Transmembrane Transporter Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Organelle Organization Negative Regulation Of Immune Response Muscle Hypertrophy Developmental Process Negative Regulation Of Apoptotic Process Cytoskeletal Protein Binding Negative Regulation Of Programmed Cell Death Z Disc Titin-telethonin Complex Sarcomerogenesis Negative Regulation Of Transcription By RNA Polymerase II Muscle Structure Development Sarcomere Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Costamere Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process T Cell Costimulation Identical Protein Binding Negative Regulation Of Biosynthetic Process Regulation Of Membrane Depolarization Regulation Of Metabolic Process Regulation Of Programmed Cell Death Skeletal Muscle Myosin Thick Filament Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To L-glutamate Regulation Of Gene Expression Rhythmic Process Sarcolemma Negative Regulation Of Rho Protein Signal Transduction Regulation Of DNA-templated Transcription Actomyosin Structure Organization Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of RNA Biosynthetic Process Myosin Filament Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Tubulin Binding Cytoskeleton Organization
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