ENO1 and KDM2A

Number of citations of the paper that reports this interaction (PubMedID 23414517)
48

Data Source:
BioGRID (two hybrid)

		ENO1	KDM2A
Description		enolase 1	lysine demethylase 2A
Image
GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Nuclear Outer Membrane Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane M Band Extracellular Exosome	Nucleus Nucleoplasm Chromosome
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding GTPase Binding	DNA Binding Transcription Coregulator Activity Protein Binding Zinc Ion Binding Oxidoreductase Activity Histone Demethylase Activity Unmethylated CpG Binding Metal Ion Binding Dioxygenase Activity Histone H3K36 Demethylase Activity Histone H3K36me/H3K36me2 Demethylase Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Negative Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Double-strand Break Repair Via Nonhomologous End Joining Chromatin Organization Chromatin Remodeling Regulation Of Transcription By RNA Polymerase II Negative Regulation Of Transcription By Competitive Promoter Binding Circadian Regulation Of Gene Expression Regulation Of Circadian Rhythm Rhythmic Process
Pathways		Glycolysis Gluconeogenesis Manipulation of host energy metabolism	HDMs demethylate histones
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form
Diseases
GWAS		Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)	A body shape index ( 34021172) Appendicular lean mass ( 33097823) Height ( 28270201 28552196) Hip circumference adjusted for BMI ( 34021172) Mean corpuscular volume ( 27863252) Prostate cancer ( 29892016) Red blood cell count ( 27863252 32888494) Waist circumference adjusted for body mass index ( 34021172) Waist-hip index ( 34021172) Waist-to-hip ratio adjusted for BMI ( 34021172)
Interacting Genes		68 interacting genes: AGTPBP1 ALDOA AMBP ANK3 ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CHKA CLK1 COL14A1 CYSLTR2 DES DRC2 DUX4 FANCA FHL1 FLNC FNDC3B FXR1 FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 OGT P4HB PAF1 PCNA PDE4B PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TNFRSF14 TRAPPC2 TTN TUBA1A UBE3A UPF2 YWHAQ YWHAZ ZBTB44	12 interacting genes: ENO1 EP300 FBXO32 FOS H3-4 H3C14 POLA2 RELA SMAD3 SMAD7 UBE2G2 ZNF512B
Entrez ID		2023	22992
HPRD ID		01400	05741
Ensembl ID		ENSG00000074800	ENSG00000173120
Uniprot IDs		A0A024R4F1 A0A2R8Y6G6 P06733	I3VM53 I3VM54 Q9Y2K7
PDB IDs		2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK 8TRL	2YU1 2YU2 4BBQ 6BYH 6C16 7UV9
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Organelle Organization Negative Regulation Of Immune Response Muscle Hypertrophy Developmental Process Negative Regulation Of Apoptotic Process Cytoskeletal Protein Binding Negative Regulation Of Programmed Cell Death Z Disc Titin-telethonin Complex Sarcomerogenesis Negative Regulation Of Transcription By RNA Polymerase II Muscle Structure Development Sarcomere Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Costamere Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process T Cell Costimulation Identical Protein Binding Negative Regulation Of Biosynthetic Process Regulation Of Membrane Depolarization Regulation Of Metabolic Process Regulation Of Programmed Cell Death Skeletal Muscle Myosin Thick Filament Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To L-glutamate Regulation Of Gene Expression Rhythmic Process Sarcolemma Negative Regulation Of Rho Protein Signal Transduction Regulation Of DNA-templated Transcription Actomyosin Structure Organization Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of RNA Biosynthetic Process Myosin Filament Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Tubulin Binding Cytoskeleton Organization	Transcription Regulator Complex Regulation Of MiRNA Transcription Regulation Of MiRNA Metabolic Process Negative Regulation Of Transcription By RNA Polymerase II DNA Binding SMAD Protein Signal Transduction Negative Regulation Of MiRNA Transcription Transcription Coactivator Binding Negative Regulation Of DNA-templated Transcription Negative Regulation Of RNA Biosynthetic Process Positive Regulation Of MiRNA Transcription Negative Regulation Of RNA Metabolic Process Chromatin Binding Positive Regulation Of MiRNA Metabolic Process Heteromeric SMAD Protein Complex Nucleoplasm Negative Regulation Of Nucleobase-containing Compound Metabolic Process Chromatin DNA Binding Cellular Response To Growth Factor Stimulus Chromatin Response To Hormone Beta-catenin Binding Transforming Growth Factor Beta Receptor Signaling Pathway Regulation Of Transcription By RNA Polymerase II Response To Growth Factor I-SMAD Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Positive Regulation Of Chondrocyte Differentiation Double-stranded DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Intracellular Protein Transport Response To Angiotensin Nucleus Regulation Of Transforming Growth Factor Beta Receptor Signaling Pathway Response To Muscle Stretch Cellular Response To Cytokine Stimulus R-SMAD Binding Regulation Of T-helper 17 Cell Differentiation Intracellular Signaling Cassette Positive Regulation Of Cell Development Cellular Response To Oxygen-containing Compound Positive Regulation Of Cell Differentiation NF-kappaB Binding Positive Regulation Of Cartilage Development DNA-binding Transcription Factor Binding Transforming Growth Factor Beta Receptor Superfamily Signaling Pathway Negative Regulation Of Macromolecule Biosynthetic Process Response To Progesterone Regulation Of DNA-templated Transcription Negative Regulation Of Biosynthetic Process
Tagcloud ?
Tagcloud (Difference) ?
Tagcloud (Intersection) ?