ENO1 and SERPING1

Number of citations of the paper that reports this interaction (PubMedID 21988832)
38

Data Source:
BioGRID (two hybrid)

		ENO1	SERPING1
Description		enolase 1	serpin family G member 1
Image
GO Annotations	Cellular Component	Phosphopyruvate Hydratase Complex Extracellular Space Nucleus Nuclear Outer Membrane Cytoplasm Cytosol Plasma Membrane Cell Cortex Cell Surface Membrane M Band Extracellular Exosome	Extracellular Region Extracellular Space Endoplasmic Reticulum Lumen Extracellular Matrix Platelet Alpha Granule Lumen Extracellular Exosome Blood Microparticle
	Molecular Function	Magnesium Ion Binding RNA Polymerase II Transcription Regulatory Region Sequence-specific DNA Binding Transcription Corepressor Binding DNA-binding Transcription Repressor Activity, RNA Polymerase II-specific DNA Binding Transcription Corepressor Activity RNA Binding Phosphopyruvate Hydratase Activity Protein Binding Lyase Activity Protein Homodimerization Activity Cadherin Binding Metal Ion Binding GTPase Binding	Serine-type Endopeptidase Inhibitor Activity Protein Binding Peptidase Inhibitor Activity
	Biological Process	Negative Regulation Of Transcription By RNA Polymerase II Gluconeogenesis Glycolytic Process Response To Virus Positive Regulation Of Plasminogen Activation Negative Regulation Of Cell Growth Negative Regulation Of DNA-templated Transcription Positive Regulation Of Muscle Contraction Canonical Glycolysis Negative Regulation Of Hypoxia-induced Intrinsic Apoptotic Signaling Pathway Positive Regulation Of ATP Biosynthetic Process	Negative Regulation Of Complement Activation, Lectin Pathway Blood Coagulation Hemostasis Blood Circulation Fibrinolysis
Pathways		Glycolysis Gluconeogenesis Manipulation of host energy metabolism	Platelet degranulation Intrinsic Pathway of Fibrin Clot Formation Defective SERPING1 causes hereditary angioedema Regulation of Complement cascade
Drugs		Zinc Copper Artenimol Zinc acetate Zinc chloride Zinc sulfate, unspecified form	PPL-100 Copper
Diseases			Complement regulatory protein defects, including the following six diseases: C1 inhibitor deficiency (hereditary angioedema); C4 binding protein alpha deficiency; C4 binding protein beta deficiency; Factor I deficiency; Decay-accelerating factor (CD55) deficiency; CD59 deficiency Hereditary angioedema
GWAS		Asthma ( 30929738) Autism spectrum disorder, attention deficit-hyperactivity disorder, bipolar disorder, major depressive disorder, and schizophrenia (combined) ( 23453885) Blood protein levels ( 30072576) Feeling tense ( 29500382) Platelet count ( 32888494) Plateletcrit ( 27863252 32888494) Tonsillectomy ( 27182965 28928442) White blood cell count ( 32888494) White blood cell count (basophil) ( 27863252)	Autism spectrum disorder or schizophrenia ( 28540026) Mean platelet volume ( 32888494) Neuroticism ( 29255261) Obesity-related traits ( 23251661) Platelet count ( 32888494) Schizophrenia ( 25056061 29483656)
Interacting Genes		68 interacting genes: AGTPBP1 ALDOA AMBP ANK3 ARID1B BCL6 BHLHE40 BRCA1 CBX5 CHEK2 CHKA CLK1 COL14A1 CYSLTR2 DES DRC2 DUX4 FANCA FHL1 FLNC FNDC3B FXR1 FYN GLIS3 GRB2 HDAC1 HEMGN HEY2 HK2 HSP90AB1 HSPB2 ITGB1 IVNS1ABP KDM2A LIG4 LINC01554 LONRF3 MCPH1 MED13 MYOC NCOR1 OGT P4HB PAF1 PCNA PDE4B PLG PPP2R5E RXFP3 SERPING1 SET SGCG SNAPC3 SRC SUMO2 SUMO4 TCAP TEAD1 TERT TNFRSF14 TRAPPC2 TTN TUBA1A UBE3A UPF2 YWHAQ YWHAZ ZBTB44	17 interacting genes: BAG6 C1R C1S CFTR ELANE ENO1 F2 HSP90AA1 MASP1 MASP2 NR4A1 PLAT PLG SELE SELP SLC30A2 SRPK2
Entrez ID		2023	710
HPRD ID		01400	06033
Ensembl ID		ENSG00000074800	ENSG00000149131
Uniprot IDs		A0A024R4F1 A0A2R8Y6G6 P06733	E9KL26 P05155
PDB IDs		2PSN 3B97 5JLZ 5LAX 5NI9 5NIG 5OCK 8TRL	2OAY 5DU3 5DUQ 7AKV 8W18
Enriched GO Terms of Interacting Partners?		Transmembrane Transporter Binding Nucleus Negative Regulation Of RNA Metabolic Process Negative Regulation Of RNA Biosynthetic Process Negative Regulation Of DNA-templated Transcription Negative Regulation Of Nucleobase-containing Compound Metabolic Process Negative Regulation Of Intracellular Signal Transduction Animal Organ Development Organelle Organization Negative Regulation Of Immune Response Muscle Hypertrophy Developmental Process Negative Regulation Of Apoptotic Process Cytoskeletal Protein Binding Negative Regulation Of Programmed Cell Death Z Disc Titin-telethonin Complex Sarcomerogenesis Negative Regulation Of Transcription By RNA Polymerase II Muscle Structure Development Sarcomere Organization Negative Regulation Of Macromolecule Biosynthetic Process Negative Regulation Of Signal Transduction Costamere Negative Regulation Of Macromolecule Metabolic Process Cellular Response To Stress Negative Regulation Of Metabolic Process T Cell Costimulation Identical Protein Binding Negative Regulation Of Biosynthetic Process Regulation Of Membrane Depolarization Regulation Of Metabolic Process Regulation Of Programmed Cell Death Skeletal Muscle Myosin Thick Filament Assembly Negative Regulation Of Cell Communication Negative Regulation Of Signaling Response To L-glutamate Regulation Of Gene Expression Rhythmic Process Sarcolemma Negative Regulation Of Rho Protein Signal Transduction Regulation Of DNA-templated Transcription Actomyosin Structure Organization Cellular Response To Platelet-derived Growth Factor Stimulus Regulation Of RNA Biosynthetic Process Myosin Filament Assembly Regulation Of Macromolecule Metabolic Process Regulation Of Macromolecule Biosynthetic Process Tubulin Binding Cytoskeleton Organization	Serine-type Peptidase Activity Serine-type Endopeptidase Activity Response To External Biotic Stimulus Zymogen Activation Activation Of Membrane Attack Complex Immune System Process Killing Of Cells Of Another Organism Opsonization Symbiont Cell Surface Peptidase Activity Extracellular Space Protein Processing Response To Other Organism Response To Stress Cell Killing Cell Surface Positive Regulation Of Leukocyte Tethering Or Rolling Defense Response Positive Regulation Of Immune System Process Negative Regulation Of Fibrinolysis Complement Activation Regulation Of Leukocyte Tethering Or Rolling Protein Maturation Proteolysis Regulation Of Fibrinolysis Fibrinolysis Immune Effector Process Positive Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Positive Regulation Of Immune Response Activation Of Immune Response Positive Regulation Of Blood Coagulation Trans-synaptic Signaling By BDNF, Modulating Synaptic Transmission Positive Regulation Of Coagulation Defense Response To Symbiont Humoral Immune Response Defense Response To Other Organism Complement Activation, Classical Pathway Blood Microparticle Regulation Of Leukocyte Adhesion To Vascular Endothelial Cell Regulation Of Cellular Extravasation Lipopolysaccharide Binding Trans-synaptic Signaling By BDNF Regulation Of Immune System Process Extracellular Region Biological Process Involved In Interaction With Symbiont Hydrolase Activity Complement Component C1 Complex Neutrophil-mediated Killing Of Gram-negative Bacterium Cell Migration Negative Regulation Of Blood Coagulation
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