TGM1 and IGSF8

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGM1	IGSF8
Description		transglutaminase 1	immunoglobulin superfamily member 8
Image			No pdb structure
GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Membrane Presynaptic Membrane Extracellular Exosome Hippocampal Mossy Fiber To CA3 Synapse
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding	Protein Binding Signaling Receptor Activity
	Biological Process	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development	Single Fertilization Nervous System Development Skeletal Muscle Tissue Development Positive Regulation Of Cell Migration Cell Motility Regulation Of Cell Motility
Pathways		Formation of the cornified envelope
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	20 interacting genes: A2M CD47 CD81 CD82 CD9 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-4 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP2-3 KRTAP2-4 KRTAP4-12 KRTAP5-7 NBPF19 NOTCH2NLA SLIT3 TGM1
Entrez ID		7051	93185
HPRD ID		01824	09438
Ensembl ID		ENSG00000092295	ENSG00000162729
Uniprot IDs		P22735	Q969P0
PDB IDs		2XZZ
Enriched GO Terms of Interacting Partners?		Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity	Keratin Filament Intermediate Filament Myoblast Fusion Involved In Skeletal Muscle Regeneration Cellular Response To Lipoprotein Particle Stimulus Myoblast Fusion Regulation Of Mononuclear Cell Migration Cell-cell Fusion Cellular Response To Low-density Lipoprotein Particle Stimulus Syncytium Formation Syncytium Formation By Plasma Membrane Fusion Macrophage Fusion Positive Regulation Of Adaptive Immune Memory Response CD4-positive, Alpha-beta T Cell Costimulation Regulation Of Macrophage Migration
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