TGM1 and DOCK2

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGM1	DOCK2
Description		transglutaminase 1	dedicator of cytokinesis 2
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GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome	Extracellular Region Cytoplasm Cytosol Cytoskeleton Plasma Membrane Endomembrane System Membrane Specific Granule Lumen Extracellular Exosome
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding	Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding Small GTPase Binding T Cell Receptor Binding
	Biological Process	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development	Membrane Raft Polarization Establishment Of T Cell Polarity Immunological Synapse Formation Myeloid Dendritic Cell Activation Involved In Immune Response Chemotaxis Cytoskeleton Organization Small GTPase-mediated Signal Transduction Myoblast Fusion Cell Migration Actin Cytoskeleton Organization T Cell Proliferation T Cell Activation Macropinocytosis Positive Thymic T Cell Selection Negative Thymic T Cell Selection Alpha-beta T Cell Activation Alpha-beta T Cell Proliferation Positive Regulation Of Phagocytosis Regulation Of Small GTPase Mediated Signal Transduction
Pathways		Formation of the cornified envelope	Nef and signal transduction Neutrophil degranulation RHOA GTPase cycle RAC1 GTPase cycle RAC2 GTPase cycle RHOG GTPase cycle Factors involved in megakaryocyte development and platelet production
Drugs
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Acne (severe) ( 24927181) Bipolar disorder ( 34002096) Body mass index and waist-hip ratio (pleiotropy) ( 29868124) Coronary artery aneurysm in Kawasaki disease ( 33772158) Placental abruption ( 29884306) Pneumococcal bacteremia ( 27236921) Prostate cancer ( 29892016) Protein quantitative trait loci ( 18464913)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	50 interacting genes: CALCOCO2 CARD10 CCNDBP1 CD247 CEBPA CRKL CYSRT1 ELMO1 GNAL GOLGA6L9 HNRNPK HOXA1 KHDRBS1 KHDRBS2 KHDRBS3 KRT31 KRT34 KRT40 KRTAP1-1 KRTAP1-3 KRTAP10-1 KRTAP10-3 KRTAP10-7 KRTAP10-8 KRTAP10-9 KRTAP12-3 KRTAP17-1 KRTAP3-1 KRTAP3-3 KRTAP4-2 KRTAP5-7 KRTAP5-9 KRTAP9-2 KRTAP9-3 KRTAP9-4 MDFI MTDH MTUS2 NBPF19 NOTCH2NLA PAK2 PCSK5 PLEKHF2 PLSCR1 RAC1 RAC2 TENM4 TGM1 TRIM23 VAV1
Entrez ID		7051	1794
HPRD ID		01824	09121
Ensembl ID		ENSG00000092295	ENSG00000134516
Uniprot IDs		P22735	H0YB76 Q5XG91 Q92608
PDB IDs		2XZZ	2RQR 2YIN 3A98 3B13 6TGB 6TGC
Enriched GO Terms of Interacting Partners?		Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity	Intermediate Filament Keratin Filament Identical Protein Binding Cytosol Structural Constituent Of Skin Epidermis SH3 Domain Binding Erythrocyte Enucleation Structural Molecule Activity Positive Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of Skeletal Muscle Acetylcholine-gated Channel Clustering Regulation Of MRNA Splicing, Via Spliceosome
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