TGM1 and ALPP

Number of citations of the paper that reports this interaction (PubMedID 32296183)
50

Data Source:
BioGRID (two hybrid)

		TGM1	ALPP
Description		transglutaminase 1	alkaline phosphatase, placental
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GO Annotations	Cellular Component	Cornified Envelope Cytosol Plasma Membrane Membrane Extracellular Exosome	Plasma Membrane Cell Surface Membrane Side Of Membrane
	Molecular Function	Protein-glutamine Gamma-glutamyltransferase Activity Protein Binding Transferase Activity Acyltransferase Activity Identical Protein Binding Metal Ion Binding	Magnesium Ion Binding Alkaline Phosphatase Activity Protein Binding Zinc Ion Binding Hydrolase Activity Phosphatase Activity Metal Ion Binding
	Biological Process	Positive Regulation Of Keratinocyte Proliferation Peptide Cross-linking Keratinocyte Differentiation Keratinization Protein Modification Process Cell Envelope Organization Positive Regulation Of Cell Cycle Animal Organ Development
Pathways		Formation of the cornified envelope	Intra-Golgi traffic
Drugs			Calcium METHYL-PHOSPHONIC ACID MONO-(4-NITRO-PHENYL) ESTER
Diseases		Lamellar ichthyosis (LI) and Non-bullous congenital ichthyosiform erythroderma (NBCIE)
GWAS			Blood protein levels ( 30072576) Height ( 19570815) Refractive error ( 32231278)
Interacting Genes		34 interacting genes: ACADL ALPP C1QTNF1 CNNM3 CRCT1 CXCL16 DOCK2 GSTP1 HSPB1 IFI30 IGSF8 ITGB4 JOSD1 KRTAP4-12 KRTAP5-9 LCE1B LCE1E LCE3A LCE4A MDK MYPOP NECTIN2 NUBP2 PLAAT4 RIN3 SCARF1 SEMG1 SEMG2 SNCA SULT4A1 TACC2 TRAPPC14 VASN VSTM4	49 interacting genes: ADAMTSL4 ALPG CRCT1 CREB5 CXCL5 CYSRT1 FBXO34 GEMIN4 GPLD1 GSC2 HOXA1 IGFBP6 KRTAP1-1 KRTAP1-3 KRTAP10-3 KRTAP10-8 KRTAP4-12 KRTAP5-9 KRTAP9-3 LATS1 LCE1B LCE1C LCE1D LCE1E LCE1F LCE2C LCE3A LCE3B LCE3C LCE3D LCE3E LCE4A LCE5A LELP1 MEOX2 MPHOSPH9 NBPF19 NLGN3 NOTCH2NLA NR4A3 NUFIP2 OTX1 PIGK POU4F2 RGS19 RGS20 SMCP TGM1 TUBA4A
Entrez ID		7051	250
HPRD ID		01824	01379
Ensembl ID		ENSG00000092295	ENSG00000163283
Uniprot IDs		P22735	B2R7C7 P05187
PDB IDs		2XZZ	1EW2 1ZEB 1ZED 1ZEF 2GLQ 3MK0 3MK1 3MK2
Enriched GO Terms of Interacting Partners?		Epidermis Development Negative Regulation Of Flagellated Sperm Motility Positive Regulation Of Serine-type Endopeptidase Activity Keratinization Positive Regulation Of Endopeptidase Activity Regulation Of Locomotion Endocytosis Positive Regulation Of Peptidase Activity	Keratinization Epidermis Development Tissue Development Intermediate Filament Keratin Filament Identical Protein Binding
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