TFF2 and TRAPPC10

		TFF2	TRAPPC10
Description		trefoil factor 2	trafficking protein particle complex subunit 10
Image		No pdb structure	No pdb structure
GO Annotations	Cellular Component	Extracellular Region Extracellular Space	Cytoplasm Golgi Apparatus Cytosol TRAPP Complex TRAPPII Protein Complex
	Molecular Function	Protein Binding CXCR4 Chemokine Receptor Binding	Protein Binding
	Biological Process	Maintenance Of Gastrointestinal Epithelium Negative Regulation Of Gastric Acid Secretion Chemokine-mediated Signaling Pathway	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport Early Endosome To Golgi Transport Golgi Vesicle Transport Vesicle Tethering
Pathways			COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs
Drugs		Pidolic acid
Diseases
GWAS
Interacting Genes		3 interacting genes: CFTR FCRL4 TRAPPC10	15 interacting genes: GET1 SLC19A1 SUMO3 TFF1 TFF2 TFF3 TMPRSS2 TRAPPC12 TRAPPC3L TRAPPC6A TRAPPC6B TRAPPC8 TRPM2 U2AF1 UBE2G2
Entrez ID		7032	7109
HPRD ID		01682	03656
Ensembl ID		ENSG00000160181	ENSG00000160218
Uniprot IDs		Q03403	P48553
PDB IDs
Enriched GO Terms of Interacting Partners?		Positive Regulation Of Anion Channel Activity Intracellularly ATP-gated Chloride Channel Activity Positive Regulation Of Voltage-gated Chloride Channel Activity Sec61 Translocon Complex Binding Positive Regulation Of Monoatomic Anion Transport Positive Regulation Of Enamel Mineralization Positive Regulation Of Tooth Mineralization Chloride Channel Inhibitor Activity Transepithelial Water Transport Chloride Channel Regulator Activity Regulation Of Enamel Mineralization Membrane Hyperpolarization Bicarbonate Transmembrane Transporter Activity Intracellular PH Elevation Amelogenesis ATPase-coupled Inorganic Anion Transmembrane Transporter Activity Regulation Of Monoatomic Anion Transport Epithelial Fluid Transport TRAPPII Protein Complex Cellular Response To Forskolin Golgi-associated Vesicle Membrane TRAPP Complex Response To Forskolin Early Endosome To Golgi Transport Chloride Transmembrane Transporter Activity Sperm Capacitation Cell Surface Bicarbonate Transport Water Transport Multicellular Organismal-level Water Homeostasis Positive Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Positive Regulation Of Ion Transmembrane Transporter Activity Cholesterol Biosynthetic Process 14-3-3 Protein Binding Fluid Transport Transepithelial Transport Intra-Golgi Vesicle-mediated Transport Vesicle Coating Vesicle Tethering Vesicle Docking Involved In Exocytosis Positive Regulation Of Transporter Activity ABC-type Transporter Activity Sterol Biosynthetic Process Chloride Channel Complex Positive Regulation Of Biomineral Tissue Development Cellular Response To CAMP Regulation Of Insulin Secretion Involved In Cellular Response To Glucose Stimulus Vesicle Docking	TRAPP Complex Vesicle Tethering Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex Maintenance Of Gastrointestinal Epithelium COPII Vesicle Coating Golgi Vesicle Transport Epithelial Structure Maintenance Digestive System Process Vesicle Organization Anatomical Structure Homeostasis Tissue Homeostasis Methotrexate Transport Methotrexate Transmembrane Transporter Activity Folate:monoatomic Anion Antiporter Activity Multicellular Organismal-level Homeostasis CXCR4 Chemokine Receptor Binding Mono-ADP-D-ribose Binding Cis-Golgi Network Cellular Localization Establishment Of Localization In Cell Folate Import Across Plasma Membrane 2',3'-cyclic GMP-AMP Binding Cyclic-GMP-AMP Transmembrane Transporter Activity Cellular Response To Temperature Stimulus Positive Regulation Of Protein Localization To Kinetochore Folic Acid Transmembrane Transporter Activity Folate Transmembrane Transport Entry Receptor-mediated Virion Attachment To Host Cell GET Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Kinetochore Assembly Negative Regulation Of Gastric Acid Secretion Viral Translation ADP-ribose Diphosphatase Activity
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