TRAPPC10 and TFF3

		TRAPPC10	TFF3
Description		trafficking protein particle complex subunit 10	trefoil factor 3
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol TRAPP Complex TRAPPII Protein Complex	Extracellular Region Extracellular Space Cytoplasm Secretory Granule
	Molecular Function	Protein Binding	Protein Binding Identical Protein Binding
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport Early Endosome To Golgi Transport Golgi Vesicle Transport Vesicle Tethering	Regulation Of Glucose Metabolic Process Maintenance Of Gastrointestinal Epithelium
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	Estrogen-dependent gene expression
Drugs
Diseases
GWAS			Spatial memory ( 31596458)
Interacting Genes		15 interacting genes: GET1 SLC19A1 SUMO3 TFF1 TFF2 TFF3 TMPRSS2 TRAPPC12 TRAPPC3L TRAPPC6A TRAPPC6B TRAPPC8 TRPM2 U2AF1 UBE2G2	6 interacting genes: PCBD1 SGTA SH3BGR TRAPPC10 UBQLN2 ZSCAN9
Entrez ID		7109	7033
HPRD ID		03656	02797
Ensembl ID		ENSG00000160218	ENSG00000160180
Uniprot IDs		P48553	Q07654
PDB IDs			1E9T 1PE3 6V1C
Enriched GO Terms of Interacting Partners?		TRAPP Complex Vesicle Tethering Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex Maintenance Of Gastrointestinal Epithelium COPII Vesicle Coating Golgi Vesicle Transport Epithelial Structure Maintenance Digestive System Process Vesicle Organization Anatomical Structure Homeostasis Tissue Homeostasis Methotrexate Transport Methotrexate Transmembrane Transporter Activity Folate:monoatomic Anion Antiporter Activity Multicellular Organismal-level Homeostasis CXCR4 Chemokine Receptor Binding Mono-ADP-D-ribose Binding Cis-Golgi Network Cellular Localization Establishment Of Localization In Cell Folate Import Across Plasma Membrane 2',3'-cyclic GMP-AMP Binding Cyclic-GMP-AMP Transmembrane Transporter Activity Cellular Response To Temperature Stimulus Positive Regulation Of Protein Localization To Kinetochore Folic Acid Transmembrane Transporter Activity Folate Transmembrane Transport Entry Receptor-mediated Virion Attachment To Host Cell GET Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Kinetochore Assembly Negative Regulation Of Gastric Acid Secretion Viral Translation ADP-ribose Diphosphatase Activity	Positive Regulation Of ERAD Pathway Regulation Of ERAD Pathway Positive Regulation Of Response To Endoplasmic Reticulum Stress 4-alpha-hydroxytetrahydrobiopterin Dehydratase Activity Tyrosine Biosynthetic Process Phenylalanine 4-monooxygenase Activity Tyrosine Biosynthetic Process, By Oxidation Of Phenylalanine TRC Complex Regulation Of Response To Endoplasmic Reticulum Stress ERAD Pathway Positive Regulation Of Proteasomal Protein Catabolic Process Negative Regulation Of G Protein-coupled Receptor Internalization Positive Regulation Of Proteolysis Involved In Protein Catabolic Process BAT3 Complex Binding Negative Regulation Of Clathrin-dependent Endocytosis Positive Regulation Of Proteolysis Regulation Of Proteasomal Protein Catabolic Process Positive Regulation Of Protein Catabolic Process Tetrahydrobiopterin Biosynthetic Process Negative Regulation Of ERAD Pathway Response To Endoplasmic Reticulum Stress Tetrahydrobiopterin Metabolic Process Post-translational Protein Targeting To Endoplasmic Reticulum Membrane TRAPPII Protein Complex Pteridine-containing Compound Biosynthetic Process Tyrosine Metabolic Process Tail-anchored Membrane Protein Insertion Into ER Membrane TRAPP Complex Negative Regulation Of Receptor Internalization Early Endosome To Golgi Transport Regulation Of Clathrin-dependent Endocytosis Regulation Of Protein Catabolic Process Regulation Of Proteolysis
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