TRAPPC10 and TRPM2

		TRAPPC10	TRPM2
Description		trafficking protein particle complex subunit 10	transient receptor potential cation channel subfamily M member 2
Image		No pdb structure
GO Annotations	Cellular Component	Cytoplasm Golgi Apparatus Cytosol TRAPP Complex TRAPPII Protein Complex	Lysosome Lysosomal Membrane Plasma Membrane Membrane Cytoplasmic Vesicle Membrane Cytoplasmic Vesicle Specific Granule Membrane Cell Projection Perikaryon Tertiary Granule Membrane Ficolin-1-rich Granule Membrane
	Molecular Function	Protein Binding	Monoatomic Ion Channel Activity Monoatomic Cation Channel Activity Calcium Channel Activity Sodium Channel Activity Manganese Ion Transmembrane Transporter Activity Calcium Ion Binding Intracellularly Gated Calcium Channel Activity Hydrolase Activity Metal Ion Binding Metal Ion Transmembrane Transporter Activity ADP-ribose Diphosphatase Activity Mono-ADP-D-ribose Binding Ligand-gated Calcium Channel Activity
	Biological Process	Endoplasmic Reticulum To Golgi Vesicle-mediated Transport Intra-Golgi Vesicle-mediated Transport Vesicle Coating Vesicle-mediated Transport Early Endosome To Golgi Transport Golgi Vesicle Transport Vesicle Tethering	Temperature Homeostasis Dendritic Cell Chemotaxis Monoatomic Ion Transport Sodium Ion Transport Calcium Ion Transport Manganese Ion Transport Response To Heat Response To Purine-containing Compound Calcium-mediated Signaling Regulation Of Actin Cytoskeleton Organization Response To Hydroperoxide Monoatomic Ion Transmembrane Transport Sodium Ion Transmembrane Transport Release Of Sequestered Calcium Ion Into Cytosol Protein Homotetramerization Regulation Of Filopodium Assembly Transmembrane Transport Cellular Response To Hydrogen Peroxide Calcium Ion Transmembrane Transport Cellular Response To Calcium Ion Manganese Ion Transmembrane Transport Cellular Response To Temperature Stimulus Zinc Ion Transmembrane Transport Dendritic Cell Differentiation Calcium Ion Transmembrane Import Into Cytosol Calcium Ion Import Across Plasma Membrane
Pathways		COPII-mediated vesicle transport RAB GEFs exchange GTP for GDP on RABs	TRP channels Neutrophil degranulation
Drugs
Diseases
GWAS			Anorectal malformation ( 31136621) Dental caries (decayed, missing and filled teeth) ( 31533690) Parkinson's disease ( 32201043)
Interacting Genes		15 interacting genes: GET1 SLC19A1 SUMO3 TFF1 TFF2 TFF3 TMPRSS2 TRAPPC12 TRAPPC3L TRAPPC6A TRAPPC6B TRAPPC8 TRPM2 U2AF1 UBE2G2	4 interacting genes: EFHC1 ITPR3 TRAPPC10 TRPC6
Entrez ID		7109	7226
HPRD ID		03656	04777
Ensembl ID		ENSG00000160218	ENSG00000142185
Uniprot IDs		P48553	B4DVI8 E9PGK7 O94759 Q14DR2
PDB IDs			6MIX 6MIZ 6MJ2 6PUO 6PUR 6PUS 6PUU 7VQ1 7VQ2 8E6Q 8E6R 8E6S 8E6T 8E6U 8E6V
Enriched GO Terms of Interacting Partners?		TRAPP Complex Vesicle Tethering Vesicle Coating Endoplasmic Reticulum To Golgi Vesicle-mediated Transport TRAPPIII Protein Complex Maintenance Of Gastrointestinal Epithelium COPII Vesicle Coating Golgi Vesicle Transport Epithelial Structure Maintenance Digestive System Process Vesicle Organization Anatomical Structure Homeostasis Tissue Homeostasis Methotrexate Transport Methotrexate Transmembrane Transporter Activity Folate:monoatomic Anion Antiporter Activity Multicellular Organismal-level Homeostasis CXCR4 Chemokine Receptor Binding Mono-ADP-D-ribose Binding Cis-Golgi Network Cellular Localization Establishment Of Localization In Cell Folate Import Across Plasma Membrane 2',3'-cyclic GMP-AMP Binding Cyclic-GMP-AMP Transmembrane Transporter Activity Cellular Response To Temperature Stimulus Positive Regulation Of Protein Localization To Kinetochore Folic Acid Transmembrane Transporter Activity Folate Transmembrane Transport Entry Receptor-mediated Virion Attachment To Host Cell GET Complex Vesicle-mediated Transport Intracellular Transport Regulation Of Kinetochore Assembly Negative Regulation Of Gastric Acid Secretion Viral Translation ADP-ribose Diphosphatase Activity	Inositol 1,4,5 Trisphosphate Binding Calcium Channel Activity Inositol 1,3,4,5 Tetrakisphosphate Binding Positive Regulation Of Cytosolic Calcium Ion Concentration Sensory Perception Of Umami Taste Inositol 1,4,5-trisphosphate-gated Calcium Channel Activity Sensory Perception Of Sweet Taste Monoatomic Ion Channel Activity Calcium Ion Homeostasis Sensory Perception Of Bitter Taste Calcium Ion Transport Calcium Ion Transmembrane Transport Inositol Hexakisphosphate Binding Intracellularly Gated Calcium Channel Activity Platelet Dense Tubular Network Membrane Negative Regulation Of Dendrite Morphogenesis Slit Diaphragm Store-operated Calcium Channel Activity Neuronal Cell Body TRAPPII Protein Complex Inorganic Ion Homeostasis TRAPP Complex Actinin Binding Cytoplasmic Side Of Endoplasmic Reticulum Membrane Early Endosome To Golgi Transport Cation Channel Complex Monoatomic Cation Homeostasis Monoatomic Ion Homeostasis Axonemal A Tubule Inner Sheath Sensory Perception Of Taste Monoatomic Cation Transmembrane Transport Metal Ion Transport Inorganic Cation Transmembrane Transport Nuclear Outer Membrane Calcium Ion Binding Intra-Golgi Vesicle-mediated Transport Vesicle Tethering Monoatomic Cation Channel Activity Positive Regulation Of Ion Transmembrane Transporter Activity Clathrin Binding Axonemal Microtubule Cerebral Cortex Cell Migration Vesicle Coating
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