TEC and GABRB1

		TEC	GABRB1
Description		tec protein tyrosine kinase	gamma-aminobutyric acid type A receptor subunit beta1
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane	Nuclear Envelope Plasma Membrane Membrane Dendrite Chloride Channel Complex Receptor Complex Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Monoatomic Anion Channel Activity Chloride Channel Activity Ligand-gated Monoatomic Ion Channel Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity GABA Receptor Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Response To Toxic Substance Central Nervous System Neuron Development Response To Progesterone Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Ovulation Cycle Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Fostamatinib Zanubrutinib	Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide gamma-Hydroxybutyric acid Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)	Adventurousness ( 30643258) Cervical cancer ( 28806749) Familial squamous cell lung carcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602) Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event) ( 28753643) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Interacting Genes		42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS	8 interacting genes: AKAP5 ARFGEF2 C1QBP NEUROD4 NOD1 PIK3CA TEC UBQLN1
Entrez ID		7006	2560
HPRD ID		02786	15924
Ensembl ID		ENSG00000135605	ENSG00000163288
Uniprot IDs		P42680	P18505 X5DNL6
PDB IDs		2LUL	9CTV 9CXB 9CXD
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process	Regulation Of Immune Response Intracellular Signal Transduction Activation Of Immune Response GABA Receptor Binding Regulation Of Intracellular Signal Transduction Protein Kinase A Regulatory Subunit Binding Regulation Of Macroautophagy Positive Regulation Of Immune Response Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Immune System Process Signal Transduction Intracellular Signaling Cassette Adrenergic Receptor Binding Immune Response-activating Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Autophagy Positive Regulation Of Immune System Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Localization To Membrane Regulation Of Innate Immune Response Kininogen Binding GABA-ergic Synapse Deoxyribonuclease Inhibitor Activity Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling T Cell Receptor Signaling Pathway Response To Butyrate Cellular Response To Hydrostatic Pressure Positive Regulation Of Endosome To Plasma Membrane Protein Transport Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Response To Stress C5-methylcytidine-containing RNA Reader Activity Negative Regulation Of MDA-5 Signaling Pathway Cytosol Phosphatidylinositol 3-kinase Complex, Class IB Symmetric Synapse Endomembrane System Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Mitochondrial Ribosome Binding Cytosolic Ribosome Assembly Negative Regulation Of RIG-I Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Mitochondrial RNA Catabolic Process
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