TEC and ARHGEF12

Number of citations of the paper that reports this interaction (PubMedID 12515866)
28

Data Source:
BioGRID (genetic interference, enzymatic study)

		TEC	ARHGEF12
Description		tec protein tyrosine kinase	Rho guanine nucleotide exchange factor 12
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane	Cytoplasm Cytosol Membrane Extracellular Exosome
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding
	Biological Process	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)	Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Height ( 31562340) Intraocular pressure ( 30054594 31798171 29785010 29617998 31959993 29235454 28073927 25637523) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)
Interacting Genes		42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS	19 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC VANGL2 VPS26C
Entrez ID		7006	23365
HPRD ID		02786	09207
Ensembl ID		ENSG00000135605	ENSG00000196914
Uniprot IDs		P42680	B4E2K6 E9PMR6 Q9NZN5
PDB IDs		2LUL	1TXD 1X86 2OMJ 2OS6
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process	Regulation Of Cellular Component Organization Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Cell Shape Regulation Of Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Endocytic Vesicle Regulation Of Developmental Process D5 Dopamine Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Cell Migration Positive Regulation Of Rho Protein Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Motility Lysophosphatidic Acid Receptor Activity Cell Motility Regulation Of Locomotion Protein Tyrosine Kinase Activity Apolipoprotein A-I-mediated Signaling Pathway Semaphorin-plexin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Glutamatergic Synapse Regulation Of Anatomical Structure Morphogenesis Nucleotide Binding Ossification Involved In Bone Maturation Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Focal Adhesion Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Semaphorin Receptor Activity Transmembrane Signaling Receptor Activity Semaphorin Receptor Complex Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Organization Basolateral Plasma Membrane Negative Regulation Of Intracellular Signal Transduction
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