TEC and COMMD8

		TEC	COMMD8
Description		tec protein tyrosine kinase	COMM domain containing 8
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GO Annotations	Cellular Component	Cytoplasm Cytosol Cytoskeleton Plasma Membrane Membrane	Nucleus Nucleoplasm Cytoplasm Cytosol
	Molecular Function	Nucleotide Binding Protein Kinase Activity Protein Tyrosine Kinase Activity Non-membrane Spanning Protein Tyrosine Kinase Activity Protein Binding ATP Binding Phospholipid Binding Zinc Ion Binding Lipid Binding Kinase Activity Transferase Activity Metal Ion Binding	Protein Binding NF-kappaB Binding
	Biological Process	Adaptive Immune Response Immune System Process Protein Phosphorylation Integrin-mediated Signaling Pathway Regulation Of Platelet Activation Intracellular Signal Transduction Tissue Regeneration T Cell Receptor Signaling Pathway B Cell Receptor Signaling Pathway	Signal Transduction
Pathways		Signaling by SCF-KIT FCERI mediated Ca+2 mobilization FCERI mediated Ca+2 mobilization Interleukin-3, Interleukin-5 and GM-CSF signaling	Neddylation
Drugs		Fostamatinib Zanubrutinib
Diseases
GWAS		Crohn's disease ( 23128233) Metabolite levels ( 23823483) Pulse pressure ( 27841878) Rheumatoid arthritis ( 24390342 30423114) Systolic blood pressure ( 27841878)	Risk-taking tendency (4-domain principal component model) ( 30643258)
Interacting Genes		42 interacting genes: ARHGAP6 ARHGEF12 BMX BTK COMMD8 DOK1 EGFR ERBB2 ERBB3 ERBB4 FASLG FBXO7 GAB1 GABRB1 GNA12 IKBKG JAK1 JAK2 KIT LRRK1 LYN MET OTUD4 PIK3R1 PIK3R2 PIK3R3 PIP4K2A PIP5K1A PLCG1 PLCG2 PLK4 PRLR PRRG4 PTPN18 PTPN21 SHC1 SOCS1 STAP1 TP53 TXK VAV1 WAS	6 interacting genes: AKR1C1 COMMD1 COXFA4L2 TEC TMX2 ZNF474
Entrez ID		7006	54951
HPRD ID		02786	13086
Ensembl ID		ENSG00000135605	ENSG00000169019
Uniprot IDs		P42680	Q9NX08
PDB IDs		2LUL	8F2R 8F2U 8P0W
Enriched GO Terms of Interacting Partners?		Cell Surface Receptor Protein Tyrosine Kinase Signaling Pathway Protein Tyrosine Kinase Activity Enzyme-linked Receptor Protein Signaling Pathway Cell Surface Receptor Signaling Pathway Intracellular Signal Transduction Signal Transduction Regulation Of Signal Transduction Kinase Activity Regulation Of Cell Communication Regulation Of Signaling Regulation Of Intracellular Signal Transduction Intracellular Signaling Cassette Protein Kinase Activity Phosphotyrosine Residue Binding Positive Regulation Of Intracellular Signal Transduction Lymphocyte Activation Cellular Developmental Process Phosphate-containing Compound Metabolic Process Positive Regulation Of Signal Transduction Epidermal Growth Factor Receptor Signaling Pathway Mononuclear Cell Differentiation Regulation Of Programmed Cell Death Cytosol Protein Phosphorylation Leukocyte Activation ERBB Signaling Pathway Non-membrane Spanning Protein Tyrosine Kinase Activity Receptor Complex Positive Regulation Of Cell Communication Positive Regulation Of Signaling Leukocyte Differentiation Phosphorylation Negative Regulation Of Programmed Cell Death Peptidyl-tyrosine Phosphorylation Fc-epsilon Receptor Signaling Pathway Cell Activation Developmental Process Fc Receptor Signaling Pathway Lymphocyte Differentiation Regulation Of Immune System Process Regulation Of Locomotion Immune System Process B Cell Activation Immune Response-regulating Cell Surface Receptor Signaling Pathway Cell Differentiation Regulation Of Immune Response Phosphatidylinositol Metabolic Process T Cell Activation ATP Binding Positive Regulation Of Immune System Process	17-alpha,20-alpha-dihydroxypregn-4-en-3-one Dehydrogenase [NAD(P)+] Activity Steroid Dehydrogenase Activity, Acting On The CH-OH Group Of Donors, NAD Or NADP As Acceptor Indanol Dehydrogenase Activity Sterol Homeostasis 3-beta-hydroxy-5-beta-steroid Dehydrogenase (NADP+) Activity 3-alpha-hydroxysteroid 3-dehydrogenase [NAD(P)+] Activity Cellular Response To Jasmonic Acid Stimulus Trans-1,2-dihydrobenzene-1,2-diol Dehydrogenase Activity Cholesterol Homeostasis Negative Regulation Of Hypoxia-inducible Factor-1alpha Signaling Pathway Positive Regulation Of Cholesterol Import Positive Regulation Of Endosome To Plasma Membrane Protein Transport Ketosteroid Monooxygenase Activity Lipid Homeostasis Regulation Of Plasma Lipoprotein Particle Levels 5-alpha-androstane-3-beta,17-beta-diol Dehydrogenase (NADP+) Activity Regulation Of Cholesterol Import Daunorubicin Metabolic Process Carboxylic Acid Binding Androsterone Dehydrogenase [NAD(P)+] Activity Doxorubicin Metabolic Process Oxidoreductase Activity, Acting On NAD(P)H, Quinone Or Similar Compound As Acceptor Testosterone Dehydrogenase (NADP+) Activity Androstan-3-alpha,17-beta-diol Dehydrogenase (NAD+) Activity Bile Acid Binding Disulfide Oxidoreductase Activity Sodium Channel Inhibitor Activity Positive Regulation Of Endocytic Recycling Negative Regulation Of Sodium Ion Transmembrane Transport Intestinal Cholesterol Absorption Aldose Reductase (NADPH) Activity Plasma Membrane To Endosome Transport Alcohol Dehydrogenase (NADP+) Activity Negative Regulation Of Protein Localization To Cell Surface Intestinal Lipid Absorption Negative Regulation Of Cellular Response To Hypoxia Progesterone Metabolic Process Negative Regulation Of Sodium Ion Transport Estradiol 17-beta-dehydrogenase [NAD(P)+] Activity Lipid Binding Low-density Lipoprotein Particle Clearance Retinal Metabolic Process Respiratory Chain Complex IV Cul2-RING Ubiquitin Ligase Complex Copper Ion Homeostasis Positive Regulation Of Protein Localization To Cell Surface Regulation Of Endocytic Recycling Bile Acid And Bile Salt Transport Mitochondria-associated Endoplasmic Reticulum Membrane Contact Site Regulation Of Cellular Response To Hypoxia
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