GABRB1

Description		gamma-aminobutyric acid type A receptor subunit beta1
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GO Annotations	Cellular Component	Nuclear Envelope Plasma Membrane Membrane Dendrite Chloride Channel Complex Receptor Complex Synapse Postsynaptic Membrane Presynaptic Active Zone Membrane Schaffer Collateral - CA1 Synapse GABA-ergic Synapse Postsynaptic Specialization Membrane GABA-A Receptor Complex
	Molecular Function	Transmembrane Signaling Receptor Activity GABA-A Receptor Activity Monoatomic Ion Channel Activity Extracellular Ligand-gated Monoatomic Ion Channel Activity Monoatomic Anion Channel Activity Chloride Channel Activity Ligand-gated Monoatomic Ion Channel Activity GABA-gated Chloride Ion Channel Activity Neurotransmitter Receptor Activity GABA Receptor Binding Ligand-gated Monoatomic Ion Channel Activity Involved In Regulation Of Presynaptic Membrane Potential G Protein-coupled Neurotransmitter Receptor Activity Involved In Regulation Of Presynaptic Membrane Potential Transmitter-gated Monoatomic Ion Channel Activity Involved In Regulation Of Postsynaptic Membrane Potential
	Biological Process	Monoatomic Ion Transport Chloride Transport Signal Transduction Gamma-aminobutyric Acid Signaling Pathway Response To Toxic Substance Central Nervous System Neuron Development Response To Progesterone Monoatomic Ion Transmembrane Transport Regulation Of Membrane Potential Ovulation Cycle Synaptic Transmission, GABAergic Regulation Of Postsynaptic Membrane Potential Cellular Response To Histamine Regulation Of Presynaptic Membrane Potential Chloride Transmembrane Transport
Pathways		Signaling by ERBB4 GABA receptor activation GABA receptor activation
Drugs		Lorazepam Ethchlorvynol Enflurane Temazepam Butabarbital Butalbital Phenytoin Etomidate Talbutal Pentobarbital Clobazam Meprobamate Eszopiclone Alprazolam Lindane Metharbital Chlordiazepoxide Amoxapine Adinazolam Lamotrigine Medroxyprogesterone acetate Clorazepic acid Midazolam Flurazepam Isoflurane Primidone Halazepam Propofol Diazepam Oxazepam Triazolam Ethanol Methoxyflurane Memantine Clonazepam Methyprylon Halothane Desflurane Flumazenil Estazolam Sevoflurane Glutethimide gamma-Hydroxybutyric acid Camazepam Delorazepam Flunitrazepam Ethyl loflazepate Cloxazolam Bromazepam Clotiazepam Fludiazepam Ketazolam Prazepam Quazepam Cinolazepam Nitrazepam Prasterone Taurine Ganaxolone Brotizolam Stiripentol Etizolam Thiocolchicoside Brexanolone Apalutamide Remimazolam 1,2-Benzodiazepine Pinazepam Medazepam Loprazolam Doxefazepam Lormetazepam Nordazepam Oxazepam acetate Cinazepam Bentazepam Mexazolam
Diseases
GWAS		Adventurousness ( 30643258) Cervical cancer ( 28806749) Familial squamous cell lung carcinoma ( 29924316) General risk tolerance (MTAG) ( 30643258) Heel bone mineral density x serum urate levels interaction ( 34046847) Major depressive disorder ( 29317602) Moderate or severe diarrhoea in darapladib-treated cardiovascular disease (time to event) ( 28753643) Obesity-related traits ( 23251661) Pulse pressure ( 27841878) Systolic blood pressure ( 27841878)
Novel Interacting Genes		8 novel interacting genes: AKAP5 ARFGEF2 C1QBP NEUROD4 NOD1 PIK3CA TEC UBQLN1
Interacting Genes		8 interacting genes: AKAP5 ARFGEF2 C1QBP NEUROD4 NOD1 PIK3CA TEC UBQLN1
Entrez ID		2560
HPRD ID		15924
Ensembl ID		ENSG00000163288
Uniprot IDs		P18505 X5DNL6
PDB IDs		9CTV 9CXB 9CXD
Enriched GO Terms of Interacting Partners?		Regulation Of Immune Response Intracellular Signal Transduction Activation Of Immune Response GABA Receptor Binding Regulation Of Intracellular Signal Transduction Protein Kinase A Regulatory Subunit Binding Regulation Of Macroautophagy Positive Regulation Of Immune Response Negative Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Regulation Of Immune System Process Signal Transduction Intracellular Signaling Cassette Adrenergic Receptor Binding Immune Response-activating Signaling Pathway Negative Regulation Of Store-operated Calcium Channel Activity Regulation Of Autophagy Positive Regulation Of Immune System Process Phosphatidylinositol 3-kinase/protein Kinase B Signal Transduction Regulation Of Signal Transduction Regulation Of Cytoplasmic Pattern Recognition Receptor Signaling Pathway Immune Response-regulating Signaling Pathway Positive Regulation Of Protein Localization To Membrane Regulation Of Innate Immune Response Kininogen Binding GABA-ergic Synapse Deoxyribonuclease Inhibitor Activity Regulation Of Cell Communication Positive Regulation Of Intracellular Signal Transduction Regulation Of Signaling T Cell Receptor Signaling Pathway Response To Butyrate Cellular Response To Hydrostatic Pressure Positive Regulation Of Endosome To Plasma Membrane Protein Transport Positive Regulation Of Tumor Necrosis Factor Superfamily Cytokine Production Positive Regulation Of Tumor Necrosis Factor Production Negative Regulation Of Toll-like Receptor 3 Signaling Pathway Regulation Of Cellular Response To Stress C5-methylcytidine-containing RNA Reader Activity Negative Regulation Of MDA-5 Signaling Pathway Cytosol Phosphatidylinositol 3-kinase Complex, Class IB Symmetric Synapse Endomembrane System Organization Regulation Of Programmed Cell Death Regulation Of Apoptotic Process Mitochondrial Ribosome Binding Cytosolic Ribosome Assembly Negative Regulation Of RIG-I Signaling Pathway Positive Regulation Of Trophoblast Cell Migration Mitochondrial RNA Catabolic Process
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