ARHGEF12 and PLXNB2

Number of citations of the paper that reports this interaction (PubMedID 12183458)
0

Data Source:
BioGRID (affinity chromatography technology)
HPRD (in vitro, two hybrid)

		ARHGEF12	PLXNB2
Description		Rho guanine nucleotide exchange factor 12	plexin B2
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GO Annotations	Cellular Component	Cytoplasm Cytosol Membrane Extracellular Exosome	Semaphorin Receptor Complex Plasma Membrane Cell Surface Membrane Extracellular Exosome
	Molecular Function	G Protein-coupled Receptor Binding Guanyl-nucleotide Exchange Factor Activity GTPase Activator Activity Protein Binding	Transmembrane Signaling Receptor Activity Protein Binding Semaphorin Receptor Activity Signaling Receptor Activity
	Biological Process	G Protein-coupled Receptor Signaling Pathway Rho Protein Signal Transduction Intracellular Signal Transduction Regulation Of Small GTPase Mediated Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway	Neural Tube Closure Regulation Of Protein Phosphorylation Cytoplasmic Translation Receptor-mediated Endocytosis Homophilic Cell Adhesion Via Plasma Membrane Adhesion Molecules Negative Regulation Of Cell Adhesion Neuroblast Proliferation Synapse Assembly Brain Development Regulation Of Cell Shape Regulation Of Neuron Projection Development Positive Regulation Of Neuron Projection Development Regulation Of Cell Migration Positive Regulation Of Cell Projection Organization Negative Regulation Of Translation In Response To Stress Cellular Response To Stress TRNA Stabilization Regulation Of GTPase Activity Positive Regulation Of Translation Positive Regulation Of Axonogenesis Regulation Of Protein Metabolic Process Semaphorin-plexin Signaling Pathway Excitatory Synapse Assembly Regulation Of Neuron Migration
Pathways		NRAGE signals death through JNK G alpha (12/13) signalling events Sema4D induced cell migration and growth-cone collapse RHOA GTPase cycle RHOB GTPase cycle RHOC GTPase cycle CDC42 GTPase cycle
Drugs
Diseases
GWAS		Appendicular lean mass ( 33097823) Attention deficit hyperactivity disorder symptom score ( 27663945) Coronary artery disease ( 29212778) Glaucoma ( 31959993 30054594) Glaucoma (high intraocular pressure) ( 33627673) Glaucoma (multi-trait analysis) ( 31959993) Glaucoma (primary open-angle) ( 33627673 29891935 25173105) Height ( 31562340) Intraocular pressure ( 30054594 31798171 29785010 29617998 31959993 29235454 28073927 25637523) Monocyte count ( 32888494) Platelet count ( 32888494) Plateletcrit ( 32888494) White blood cell count ( 32888494)	Acne (severe) ( 24927181) Blond vs. brown/black hair color ( 30531825) Blood protein levels ( 30072576) Cutaneous malignant melanoma ( 32341527) Cutaneous melanoma or hair colour ( 32341527) High light scatter reticulocyte count ( 32888494) High light scatter reticulocyte percentage of red cells ( 32888494) Lymphocyte count ( 32888494) Nevus count or cutaneous melanoma ( 32341527) Reticulocyte count ( 32888494) Reticulocyte fraction of red cells ( 32888494) Sensorimotor dexterity ( 31596458) Systolic blood pressure ( 30224653)
Interacting Genes		19 interacting genes: ABCA1 CD44 CLK1 CUL3 EGFR GNA12 GNA13 IGF1R KLHL20 LPAR1 LPAR2 PLXNB1 PLXNB2 PTPRF RHOA RPS6KA1 TEC VANGL2 VPS26C	9 interacting genes: AIFM2 ARHGEF11 ARHGEF12 CENPU HDLBP HMOX2 PFDN1 PTN RND1
Entrez ID		23365	23654
HPRD ID		09207	05050
Ensembl ID		ENSG00000196914	ENSG00000196576
Uniprot IDs		B4E2K6 E9PMR6 Q9NZN5	O15031
PDB IDs		1TXD 1X86 2OMJ 2OS6	4E71
Enriched GO Terms of Interacting Partners?		Regulation Of Cellular Component Organization Signal Transduction Regulation Of Intracellular Signal Transduction Regulation Of Rho Protein Signal Transduction Regulation Of Cell Morphogenesis Regulation Of Cell Shape Regulation Of Small GTPase Mediated Signal Transduction Rho Protein Signal Transduction Endocytic Vesicle Regulation Of Developmental Process D5 Dopamine Receptor Binding Regulation Of Signal Transduction Cell Surface Receptor Signaling Pathway Plasma Membrane Cell Migration Positive Regulation Of Rho Protein Signal Transduction Adenylate Cyclase-modulating G Protein-coupled Receptor Signaling Pathway Regulation Of Cell Migration Intracellular Signal Transduction Regulation Of Cell Communication Regulation Of Signaling Regulation Of Cell Motility Lysophosphatidic Acid Receptor Activity Cell Motility Regulation Of Locomotion Protein Tyrosine Kinase Activity Apolipoprotein A-I-mediated Signaling Pathway Semaphorin-plexin Signaling Pathway Positive Regulation Of Intracellular Signal Transduction Rho-activating G Protein-coupled Receptor Signaling Pathway Adenylate Cyclase-activating G Protein-coupled Receptor Signaling Pathway Glutamatergic Synapse Regulation Of Anatomical Structure Morphogenesis Nucleotide Binding Ossification Involved In Bone Maturation Cell Surface Regulation Of Plasma Membrane Bounded Cell Projection Organization Regulation Of Cell Projection Organization G Protein Activity Positive Regulation Of Small GTPase Mediated Signal Transduction Focal Adhesion Anatomical Structure Morphogenesis Regulation Of Neuron Projection Development Semaphorin Receptor Activity Transmembrane Signaling Receptor Activity Semaphorin Receptor Complex Positive Regulation Of MAPK Cascade Positive Regulation Of Cellular Component Organization Basolateral Plasma Membrane Negative Regulation Of Intracellular Signal Transduction
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