SPTBN1 and PKNOX1

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		SPTBN1	PKNOX1
Description		spectrin beta, non-erythrocytic 1	PBX/knotted 1 homeobox 1
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GO Annotations	Cellular Component	Nucleus Nucleolus Cytoplasm Cytosol Cytoskeleton Plasma Membrane Spectrin Postsynaptic Density Spectrin-associated Cytoskeleton Membrane Cell Junction Axolemma Cortical Cytoskeleton Cortical Actin Cytoskeleton M Band Cuticular Plate Protein-containing Complex Cell Projection Extracellular Exosome Postsynapse Glutamatergic Synapse	Chromatin Nucleus Transcription Regulator Complex Cytoplasm
	Molecular Function	RNA Binding Actin Binding Structural Constituent Of Cytoskeleton Protein Binding Calmodulin Binding Phospholipid Binding Ankyrin Binding Protein-containing Complex Binding Cadherin Binding Actin Filament Binding GTPase Binding	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Mitotic Cytokinesis Plasma Membrane Organization Central Nervous System Development Vesicle-mediated Transport Central Nervous System Formation Actin Cytoskeleton Organization Positive Regulation Of Interleukin-2 Production Golgi To Plasma Membrane Protein Transport Actin Filament Capping Regulation Of SMAD Protein Signal Transduction Membrane Assembly Protein Localization To Plasma Membrane Regulation Of Protein Localization To Plasma Membrane Positive Regulation Of Protein Localization To Plasma Membrane	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Nephrin family interactions NCAM signaling for neurite out-growth NCAM signaling for neurite out-growth Interaction between L1 and Ankyrins Interaction between L1 and Ankyrins RAF/MAP kinase cascade COPI-mediated anterograde transport RHOU GTPase cycle RHOV GTPase cycle Sensory processing of sound by inner hair cells of the cochlea Sensory processing of sound by outer hair cells of the cochlea Signaling by FLT3 fusion proteins Signaling by FLT3 fusion proteins	Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs		Calcium 1D-myo-inositol 1,4,5-trisphosphate
Diseases
GWAS		Age-related hearing impairment ( 34108613) Basophil percentage of white cells ( 32888494) Bone mineral density (spine) ( 19079262 18445777 19801982) Bone properties (heel) ( 24430505) Bone ultrasound measurement (broadband ultrasound attenuation) ( 28472463) Bone ultrasound measurement (velocity of sound) ( 28472463) Chronic kidney disease ( 31152163) Electrocardiogram morphology (amplitude at temporal datapoints) ( 32916098) Estimated glomerular filtration rate ( 31152163) Fractures ( 30158200) Heel bone mineral density ( 28869591 30598549) Height ( 31562340) HOMA-B (corrected for HOMA-IR) ( 30369944) Intraocular pressure ( 30591961 29785010 29617998 30054594 31959993) Liver enzyme levels (alkaline phosphatase) ( 33972514) Lumbar spine bone mineral density ( 22504420 29499414) Lumbar spine bone mineral density (integral) ( 27476799) Lumbar spine bone mineral density (trabecular) ( 27476799) Mean platelet volume ( 32888494) Myopia (pathological) ( 22685421) Neutrophil count ( 32888494) Pars triangularis volume ( 31530798) PR interval ( 32439900) Red blood cell count ( 32888494) Refractive error ( 32231278) Serum alkaline phosphatase levels ( 33547301) Urate levels ( 31578528) White blood cell count ( 32888494)	Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)
Interacting Genes		59 interacting genes: ACTR1A ANK2 APC ATF7IP CAPN1 CDC5L CEP63 COPB1 CPNE1 CPNE4 CSNK2A1 CTNNA1 DSCAM DSCR9 DYRK1A EIF3H EPB41 EPB41L3 FTCD GOLGA6L10 GRB2 GRIA2 HSPB1 ITSN1 MAPK14 MEF2C NF2 NOP53 NRIP1 PACSIN1 PCNT PJA1 PKNOX1 PLCB1 PLEKHA5 PRKACA PTEN PYGO1 RINT1 RNF10 SEPTIN8 SH3BP5 SMAD3 SMAD4 SMAD9 SNAPIN SNCA SPTAN1 SREBF2 STAT1 STXBP1 SUMO2 THAP3 TNIK TRAF3IP1 TTC3 YWHAG ZNF251 ZNF512B	58 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 MX2 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PCNT PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3
Entrez ID		6711	5316
HPRD ID		01683	03653
Ensembl ID		ENSG00000115306	ENSG00000160199
Uniprot IDs		B2ZZ89 Q01082	B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87
PDB IDs		1AA2 1BKR 3EDV	1X2N
Enriched GO Terms of Interacting Partners?		Cytosol Intracellular Signal Transduction Cytoplasm Regulation Of Protein Stability Cytoskeletal Protein Binding Regulation Of Transport Signal Transduction In Response To DNA Damage Negative Regulation Of Cell Cycle Phase Transition DNA Damage Checkpoint Signaling SMAD Protein Complex Protein Stabilization Regulation Of Protein Localization Positive Regulation Of Metabolic Process Heteromeric SMAD Protein Complex Glutamatergic Synapse Regulation Of Cellular Component Organization Regulation Of Intracellular Transport Negative Regulation Of Protein Catabolic Process Signal Transduction Negative Regulation Of Cell Cycle Process Regulation Of Protein Catabolic Process Negative Regulation Of Protein Metabolic Process Cytoskeleton Osteoblast Differentiation Regulation Of Cell Communication Regulation Of Biological Quality Negative Regulation Of Cell Communication Negative Regulation Of Signaling Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription Positive Regulation Of Intracellular Transport Negative Regulation Of Protein-containing Complex Assembly Negative Regulation Of Intracellular Signal Transduction Regulation Of Transcription By RNA Polymerase II Positive Regulation Of Biosynthetic Process Ligand-gated Ion Channel Signaling Pathway Postsynapse Positive Regulation Of Macromolecule Metabolic Process Negative Regulation Of Signal Transduction Positive Regulation Of Transcription By RNA Polymerase II Vesicle-mediated Transport In Synapse Regulation Of SNARE Complex Assembly Positive Regulation Of Protein Localization Regulation Of Cell Cycle Phase Transition Negative Regulation Of Macromolecule Metabolic Process Positive Regulation Of Transport I-SMAD Binding Positive Regulation Of RNA Metabolic Process Negative Regulation Of Cellular Component Organization Cell Junction Organization	Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding
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