PKNOX1 and BRD2

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PKNOX1	BRD2
Description		PBX/knotted 1 homeobox 1	bromodomain containing 2
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GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Chromatin Nucleus Nucleoplasm Chromosome Cytoplasm Nuclear Speck
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding	Chromatin Binding Protein Serine/threonine Kinase Activity Protein Binding Protein-macromolecule Adaptor Activity Histone Binding Histone H4K12ac Reader Activity Histone H4K5ac Reader Activity Histone H3K14ac Reader Activity Acetylation-dependent Protein Binding
	Biological Process	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II	Neural Tube Closure Chromatin Organization Nucleosome Assembly Chromatin Remodeling Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Cell Surface Receptor Signaling Pathway Via JAK-STAT Spermatogenesis Regulation Of Gene Expression Protein Localization To Chromatin T-helper 17 Cell Lineage Commitment Chromatin Looping Positive Regulation Of T-helper 17 Cell Lineage Commitment
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis	RUNX3 regulates p14-ARF
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)	Asthma ( 31619474) Autism spectrum disorder or schizophrenia ( 28540026) Crohn's disease ( 28008999) Feeling nervous ( 29500382) Hemoglobin levels ( 32327693) Inflammatory bowel disease ( 28008999) Ulcerative colitis ( 28008999)
Interacting Genes		58 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 MX2 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PCNT PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3	18 interacting genes: CDC42EP4 CLCN2 DDR1 E2F1 E2F2 ECEL1 H2BC26 H4C16 HLA-DQA1 HOXC6 MECOM PHF1 PKNOX1 PRNP PSMB9 RAC2 SPOP TOP1
Entrez ID		5316	6046
HPRD ID		03653	03326
Ensembl ID		ENSG00000160199	ENSG00000204256
Uniprot IDs		B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87	A0A1U9X7A8 E9PIQ3 P25440 X5CF57
PDB IDs		1X2N	1X0J 2DVQ 2DVR 2DVS 2DVV 2E3K 2G4A 2YDW 2YEK 3AQA 3ONI 4A9E 4A9F 4A9H 4A9I 4A9J 4A9M 4A9N 4A9O 4AKN 4ALG 4ALH 4J1P 4MR5 4MR6 4QEU 4QEV 4QEW 4UYF 4UYG 4UYH 5BT5 5DFB 5DFC 5DFD 5DW1 5EK9 5HEL 5HEM 5HEN 5HFQ 5IBN 5IG6 5N2L 5O38 5O39 5O3A 5O3B 5O3C 5O3D 5O3E 5O3F 5O3G 5O3H 5O3I 5S9O 5U5S 5U6V 5UEW 5XHE 5XHK 6CUI 6DB0 6DBC 6DDI 6DDJ 6E6J 6FFE 6FFF 6FFG 6I80 6I81 6JKE 6K04 6K05 6MO7 6MO8 6MO9 6MOA 6ONY 6SWO 6SWP 6TQ1 6TQ2 6U61 6U71 6U8H 6ULQ 6ULT 6VIY 6WWB 6YTM 6Z7F 6Z8P 6ZB0 6ZB1 6ZB2 7DPN 7DPO 7ENV 7ENZ 7EO5 7JX7 7L6D 7L9G 7L9J 7L9K 7LAK 7NPY 7NPZ 7NQ0 7NQ1 7NQ2 7NQ3 7NQ5 7NQ7 7NQ8 7NQ9 7NQI 7NQJ 7OE4 7OE5 7OE6 7OE8 7OE9 7OEP 7OER 7OES 7OET 7OGY 7Q5O 7USG 7USH 7USI 7UU0 7VRH 7VRI 7VRK 7VRM 7VRO 7VRQ 7VRZ 7VS0 7VS1 7VSF 7WLN 7WMQ 7WMU 7WN5 7WNA 7WNI 8B5G 8B5H 8B5I 8B5J 8CV7 8DNQ 8PX2 8PX8 8SB6 8WYG 8Z69 9FBX
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding	Lens Fiber Cell Apoptotic Process Rb-E2F Complex DNA Binding
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