PKNOX1 and CMYA5

Number of citations of the paper that reports this interaction (PubMedID 35914814)
83

Data Source:
BioGRID (two hybrid)

		PKNOX1	CMYA5
Description		PBX/knotted 1 homeobox 1	cardiomyopathy associated 5
Image			No pdb structure
GO Annotations	Cellular Component	Chromatin Nucleus Transcription Regulator Complex Cytoplasm	Nucleus Cytoplasm Sarcoplasmic Reticulum M Band Perinuclear Region Of Cytoplasm
	Molecular Function	RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding DNA-binding Transcription Factor Activity, RNA Polymerase II-specific DNA Binding Chromatin Binding DNA-binding Transcription Factor Activity Protein Binding Sequence-specific DNA Binding Sequence-specific Double-stranded DNA Binding
	Biological Process	Angiogenesis Regulation Of DNA-templated Transcription Regulation Of Transcription By RNA Polymerase II Transcription By RNA Polymerase II Hemopoiesis T Cell Differentiation Erythrocyte Differentiation Camera-type Eye Development Positive Regulation Of Transcription By RNA Polymerase II
Pathways		Activation of anterior HOX genes in hindbrain development during early embryogenesis
Drugs
Diseases
GWAS		Biochemical measures ( 19260141) Blood and toenail selenium levels ( 25343990) Cognitive performance ( 20125193) Information processing speed ( 21130836)	Bone mineral content ( 31790847) Hepatitis B surface antigen seroclearance in chronic hepatitis B infection ( 29975729) Obesity ( 23818313) Toenail selenium levels ( 25343990)
Interacting Genes		58 interacting genes: ANKRD49 APC APP ARL13B BAIAP2 BEX4 BLOC1S5 BORCS6 BRD2 C1S CAPRIN1 CMYA5 EEF1A2 EXOC7 FAM110B FHL2 FIBP FMNL2 GAS7 HMGB2 HOXA1 HOXB6 HOXB7 HOXD9 ITGB3BP KIF1A KIF1B MACF1 MEIS1 MPP3 MX2 NRIP1 NUP58 PAX6 PBX1 PBX2 PBX3 PCNT PFDN2 POU2F1 PRSS3 RAB11FIP4 RFX3 RNF40 SPTBN1 STAT1 STAT6 SYNM TCOF1 TEKT4P2 TET2 TLX1 TRIM59 TTC3 UBR1 VPS37C WIZ ZBTB3	10 interacting genes: CAPN3 CLIP4 DTNBP1 DYSF HSPB2 IL6ST MYBPC2 OPTN PKNOX1 SNAPIN
Entrez ID		5316	202333
HPRD ID		03653	16728
Ensembl ID		ENSG00000160199	ENSG00000164309
Uniprot IDs		B4DGV5 E7EPN6 P55347 Q6PKH2 Q96I87	Q8N3K9
PDB IDs		1X2N
Enriched GO Terms of Interacting Partners?		Pattern Specification Process Positive Regulation Of Transcription By RNA Polymerase II Chromatin DNA-binding Transcription Factor Activity DNA-binding Transcription Factor Activity, RNA Polymerase II-specific RNA Polymerase II Cis-regulatory Region Sequence-specific DNA Binding Positive Regulation Of RNA Biosynthetic Process Positive Regulation Of DNA-templated Transcription DNA-binding Transcription Activator Activity, RNA Polymerase II-specific Regulation Of Transcription By RNA Polymerase II Regionalization Positive Regulation Of RNA Metabolic Process Positive Regulation Of Nucleobase-containing Compound Metabolic Process Regulation Of DNA-templated Transcription Regulation Of RNA Biosynthetic Process Embryonic Morphogenesis Regulation Of RNA Metabolic Process Microtubule Anatomical Structure Morphogenesis Anterior/posterior Pattern Specification Sequence-specific DNA Binding RNA Polymerase II Core Promoter Sequence-specific DNA Binding Regulation Of Primary Metabolic Process Animal Organ Morphogenesis Eye Development Regulation Of Nucleobase-containing Compound Metabolic Process Microtubule-based Transport Nucleus Proximal/distal Pattern Formation Retrograde Neuronal Dense Core Vesicle Transport DNA Binding Axo-dendritic Transport Positive Regulation Of Macromolecule Biosynthetic Process Regulation Of Macromolecule Metabolic Process Organelle Transport Along Microtubule Transport Along Microtubule Positive Regulation Of Biosynthetic Process Neuron Development Sensory Organ Development Positive Regulation Of Macromolecule Metabolic Process Regulation Of Dendritic Spine Morphogenesis Dense Core Granule Cytoskeletal Transport Transcription Coregulator Binding Anterograde Axonal Transport Regulation Of Metabolic Process Vesicle Transport Along Microtubule Positive Regulation Of Metabolic Process Cytoskeleton-dependent Intracellular Transport Regulation Of Gene Expression Transcription Corepressor Binding	Regulation Of Neurotransmitter Secretion Anterograde Synaptic Vesicle Transport BLOC-1 Complex Synaptic Vesicle Membrane Structural Constituent Of Muscle T-tubule Sarcomere Organization Vesicle Transport Along Microtubule Synaptic Vesicle Transport Anterograde Axonal Transport Melanosome Organization Pigment Granule Organization Regulation Of Synaptic Vesicle Exocytosis Calcium-dependent Self Proteolysis Monocyte Activation Involved In Immune Response Vesicle Cytoskeletal Trafficking Positive Regulation Of Late Endosome To Lysosome Transport Axon Cytoplasm Axonal Transport Ligase Regulator Activity Positive Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Actin Cytoskeleton Organization Response To Unfolded Protein Interleukin-27 Receptor Activity Leukemia Inhibitory Factor Receptor Activity Interleukin-6 Binding Interleukin-6 Receptor Activity Oncostatin-M Receptor Complex Cytoplasmic Vesicle Axo-dendritic Transport Organelle Transport Along Microtubule Positive Regulation Of Glutamate Neurotransmitter Secretion In Response To Membrane Depolarization Organelle Organization Actin Filament-based Process Cytoskeleton Organization Regulation Of Satellite Cell Activation Involved In Skeletal Muscle Regeneration Oncostatin-M Receptor Activity Interleukin-6 Receptor Complex Ciliary Neurotrophic Factor Receptor Complex Establishment Of Vesicle Localization Actomyosin Structure Organization Sarcolemma Somatic Muscle Development Ciliary Neurotrophic Factor Receptor Activity Leukemia Inhibitory Factor Signaling Pathway Interleukin-11 Receptor Activity Oncostatin-M-mediated Signaling Pathway Interleukin-11 Binding Vesicle Localization Regulation Of Regulated Secretory Pathway
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